Progress in the understanding of the protein C anticoagulant pathway.
(2004) In International Journal of Hematology 79(2). p.109-116- Abstract
- A natural anticoagulant pathway denoted the protein C system provides specific and efficient control of blood coagulation. Protein C is the key component of the system and circulates in the blood as a zymogen to an anticoagulant serine protease.Activation of protein C is achieved on the surface of endothelial cells by thrombin bound to the membrane protein thrombomodulin. The endothelial protein C receptor stimulates the activation of protein C on the endothelium. Activated protein C (APC) modulates blood coagulation by cleaving a limited number of peptide bonds in factor VIIIa (FVIIIa) and factor Va (FVa), cofactors in the activation of factor X and prothrombin, respectively.Vitamin K-dependent protein S stimulates the APC-mediated... (More)
- A natural anticoagulant pathway denoted the protein C system provides specific and efficient control of blood coagulation. Protein C is the key component of the system and circulates in the blood as a zymogen to an anticoagulant serine protease.Activation of protein C is achieved on the surface of endothelial cells by thrombin bound to the membrane protein thrombomodulin. The endothelial protein C receptor stimulates the activation of protein C on the endothelium. Activated protein C (APC) modulates blood coagulation by cleaving a limited number of peptide bonds in factor VIIIa (FVIIIa) and factor Va (FVa), cofactors in the activation of factor X and prothrombin, respectively.Vitamin K-dependent protein S stimulates the APC-mediated regulation of coagulation. Not only is protein S involved in the degradation of FVIIIa, but so is FV, which in recent years has been found to be a Janus-faced protein with both procoagulant and anticoagulant potentials.A number of genetic defects affecting the anticoagulant function of the protein C system, eg,APC resistance (Arg506Gln or FV Leiden) and deficiencies of protein C and protein S constitute major risk factors of venous thrombosis.The protein C system also has anti-inflammatory and antiapoptotic potentials,the molecular mechanisms of which are beginning to be unraveled.APC has emerged in recent years as a useful therapeutic compound in the treatment of severe septic shock.The beneficial effect of APC is believed be due to both its anticoagulant and its anti-inflammatory properties. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/121489
- author
- Dahlbäck, Björn LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Hematology
- volume
- 79
- issue
- 2
- pages
- 109 - 116
- publisher
- Springer
- external identifiers
-
- pmid:15005336
- wos:000189189200002
- scopus:18144440602
- ISSN
- 0925-5710
- DOI
- 10.1532/IJH97.03149
- language
- English
- LU publication?
- yes
- id
- 310799c1-12dd-4383-a3f8-eb22d05703d0 (old id 121489)
- alternative location
- http://cardenjennings.metapress.com/openurl.asp?genre=article&issn=0925-5710&volume=79&issue=2&spage=109
- date added to LUP
- 2016-04-01 11:38:22
- date last changed
- 2022-01-26 07:59:59
@article{310799c1-12dd-4383-a3f8-eb22d05703d0, abstract = {{A natural anticoagulant pathway denoted the protein C system provides specific and efficient control of blood coagulation. Protein C is the key component of the system and circulates in the blood as a zymogen to an anticoagulant serine protease.Activation of protein C is achieved on the surface of endothelial cells by thrombin bound to the membrane protein thrombomodulin. The endothelial protein C receptor stimulates the activation of protein C on the endothelium. Activated protein C (APC) modulates blood coagulation by cleaving a limited number of peptide bonds in factor VIIIa (FVIIIa) and factor Va (FVa), cofactors in the activation of factor X and prothrombin, respectively.Vitamin K-dependent protein S stimulates the APC-mediated regulation of coagulation. Not only is protein S involved in the degradation of FVIIIa, but so is FV, which in recent years has been found to be a Janus-faced protein with both procoagulant and anticoagulant potentials.A number of genetic defects affecting the anticoagulant function of the protein C system, eg,APC resistance (Arg506Gln or FV Leiden) and deficiencies of protein C and protein S constitute major risk factors of venous thrombosis.The protein C system also has anti-inflammatory and antiapoptotic potentials,the molecular mechanisms of which are beginning to be unraveled.APC has emerged in recent years as a useful therapeutic compound in the treatment of severe septic shock.The beneficial effect of APC is believed be due to both its anticoagulant and its anti-inflammatory properties.}}, author = {{Dahlbäck, Björn}}, issn = {{0925-5710}}, language = {{eng}}, number = {{2}}, pages = {{109--116}}, publisher = {{Springer}}, series = {{International Journal of Hematology}}, title = {{Progress in the understanding of the protein C anticoagulant pathway.}}, url = {{http://dx.doi.org/10.1532/IJH97.03149}}, doi = {{10.1532/IJH97.03149}}, volume = {{79}}, year = {{2004}}, }