Advanced

Properties of an adult spinal sensorimotor circuit shaped through early postnatal experience.

Petersson, Per LU ; Granmo, Marcus LU and Schouenborg, Jens LU (2004) In Journal of Neurophysiology 92(1). p.280-288
Abstract
During development, information about the three-dimensional shape and mechanical properties of the body is laid down in the synaptic connectivity of sensorimotor systems through adaptive mechanisms. This functional adaptation occurs through alteration of connection properties. Here, we characterize the differences between strong and weak connections in the nociceptive withdrawal reflex in adult decerebrate spinal rats, representing the preserved end product of the developmental adaptation process. Stronger excitatory reflex connections from the skin onto a muscle had relatively higher gain in their input-output relations, shorter onset latencies ( up to similar to 150 ms) and lower trial-to-trial variability in relation to response... (More)
During development, information about the three-dimensional shape and mechanical properties of the body is laid down in the synaptic connectivity of sensorimotor systems through adaptive mechanisms. This functional adaptation occurs through alteration of connection properties. Here, we characterize the differences between strong and weak connections in the nociceptive withdrawal reflex in adult decerebrate spinal rats, representing the preserved end product of the developmental adaptation process. Stronger excitatory reflex connections from the skin onto a muscle had relatively higher gain in their input-output relations, shorter onset latencies ( up to similar to 150 ms) and lower trial-to-trial variability in relation to response amplitude (SD similar to mean(1/2)) than weaker pathways. Although inhibitory and excitatory nociceptive receptive fields of a muscle overlap to some degree, the results indicate that the inhibitory input is not a major determinant of the gain distribution within the excitatory receptive field and vice versa. The N-methyl-D-aspartate ( NMDA) receptor antagonist, D-2-amino-5-phosphonovalerate (0.1 - 1 mug), applied topically on the spinal cord reduced the gain, whereas the response amplitude was mainly reduced by an absolute number by the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor antagonist, 6-nitro-7-sulfamoylbenzo(f) quinoxaline-2,3- dione ( 1 - 10 mug). The results indicate that NMDA receptors have a critical role in gain regulation in the nociceptive withdrawal reflex system. It is suggested that after normal postnatal experience-dependent adaptation, the number of connections from a given skin site onto the reflex encoding interneurons is a major determinant of the difference in gain. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neurophysiology
volume
92
issue
1
pages
280 - 288
publisher
American Physiological Society
external identifiers
  • wos:000222179100026
  • pmid:14985408
  • scopus:3042638783
ISSN
0022-3077
DOI
10.1152/jn.00063.2004
language
English
LU publication?
yes
id
2972bcb1-7d9d-4a4e-b7ee-b0c8b26754dd (old id 121624)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14985408&dopt=Abstract
date added to LUP
2007-07-18 16:17:39
date last changed
2017-06-18 04:20:56
@article{2972bcb1-7d9d-4a4e-b7ee-b0c8b26754dd,
  abstract     = {During development, information about the three-dimensional shape and mechanical properties of the body is laid down in the synaptic connectivity of sensorimotor systems through adaptive mechanisms. This functional adaptation occurs through alteration of connection properties. Here, we characterize the differences between strong and weak connections in the nociceptive withdrawal reflex in adult decerebrate spinal rats, representing the preserved end product of the developmental adaptation process. Stronger excitatory reflex connections from the skin onto a muscle had relatively higher gain in their input-output relations, shorter onset latencies ( up to similar to 150 ms) and lower trial-to-trial variability in relation to response amplitude (SD similar to mean(1/2)) than weaker pathways. Although inhibitory and excitatory nociceptive receptive fields of a muscle overlap to some degree, the results indicate that the inhibitory input is not a major determinant of the gain distribution within the excitatory receptive field and vice versa. The N-methyl-D-aspartate ( NMDA) receptor antagonist, D-2-amino-5-phosphonovalerate (0.1 - 1 mug), applied topically on the spinal cord reduced the gain, whereas the response amplitude was mainly reduced by an absolute number by the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor antagonist, 6-nitro-7-sulfamoylbenzo(f) quinoxaline-2,3- dione ( 1 - 10 mug). The results indicate that NMDA receptors have a critical role in gain regulation in the nociceptive withdrawal reflex system. It is suggested that after normal postnatal experience-dependent adaptation, the number of connections from a given skin site onto the reflex encoding interneurons is a major determinant of the difference in gain.},
  author       = {Petersson, Per and Granmo, Marcus and Schouenborg, Jens},
  issn         = {0022-3077},
  language     = {eng},
  number       = {1},
  pages        = {280--288},
  publisher    = {American Physiological Society},
  series       = {Journal of Neurophysiology},
  title        = {Properties of an adult spinal sensorimotor circuit shaped through early postnatal experience.},
  url          = {http://dx.doi.org/10.1152/jn.00063.2004},
  volume       = {92},
  year         = {2004},
}