Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer
Mitelman, Felix LU
; Johansson, Bertil
LU
and Mertens, Fredrik
LU
(2004)
In Nature Genetics
36(4).
p.331-334
- Abstract
Cytogenetic aberrations have been reported in 45,000 human neoplasms. Structural balanced rearrangements are associated with distinct tumor subtypes with remarkable specificity and have been essential for identifying genes involved in tumorigenesis. All balanced rearrangements that have been characterized molecularly act by deregulating a gene in one of the breakpoints or by creating a fusion gene. Because most recurrent aberrations and rearranged genes have been found in hematological disorders, whereas numerous genomic imbalances have been identified in solid tumors, it has become generally accepted that there are pathogenetic differences between these neoplasms. We here show that in every tumor type, the numbers of recurrent balanced... (More)
Cytogenetic aberrations have been reported in 45,000 human neoplasms. Structural balanced rearrangements are associated with distinct tumor subtypes with remarkable specificity and have been essential for identifying genes involved in tumorigenesis. All balanced rearrangements that have been characterized molecularly act by deregulating a gene in one of the breakpoints or by creating a fusion gene. Because most recurrent aberrations and rearranged genes have been found in hematological disorders, whereas numerous genomic imbalances have been identified in solid tumors, it has become generally accepted that there are pathogenetic differences between these neoplasms. We here show that in every tumor type, the numbers of recurrent balanced chromosome abnormalities, fusion genes and genes rearranged as a consequence of balanced aberrations are simply a function of the number of cases with an abnormal karyotype. Hence, there may not be any fundamental tissue-specific differences in the genetic mechanisms by which neoplasia is initiated.
(Less)
- author
- Mitelman, Felix
LU
; Johansson, Bertil
LU
and Mertens, Fredrik
LU
- organization
- publishing date
- 2004-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Artificial Gene Fusion, Chromosome Aberrations, Humans, Neoplasms, Journal Article, Research Support, Non-U.S. Gov't
- in
- Nature Genetics
- volume
- 36
- issue
- 4
- pages
- 4 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000220647200013
- pmid:15054488
- scopus:1842535882
- pmid:15054488
- ISSN
- 1546-1718
- DOI
- 10.1038/ng1335
- language
- English
- LU publication?
- yes
- id
- 73927d4e-d3d7-4ad0-be67-e920e3450044 (old id 121883)
- date added to LUP
- 2016-04-01 16:06:45
- date last changed
- 2022-01-28 17:22:44
@article{73927d4e-d3d7-4ad0-be67-e920e3450044,
abstract = {{<p>Cytogenetic aberrations have been reported in 45,000 human neoplasms. Structural balanced rearrangements are associated with distinct tumor subtypes with remarkable specificity and have been essential for identifying genes involved in tumorigenesis. All balanced rearrangements that have been characterized molecularly act by deregulating a gene in one of the breakpoints or by creating a fusion gene. Because most recurrent aberrations and rearranged genes have been found in hematological disorders, whereas numerous genomic imbalances have been identified in solid tumors, it has become generally accepted that there are pathogenetic differences between these neoplasms. We here show that in every tumor type, the numbers of recurrent balanced chromosome abnormalities, fusion genes and genes rearranged as a consequence of balanced aberrations are simply a function of the number of cases with an abnormal karyotype. Hence, there may not be any fundamental tissue-specific differences in the genetic mechanisms by which neoplasia is initiated.</p>}},
author = {{Mitelman, Felix and Johansson, Bertil and Mertens, Fredrik}},
issn = {{1546-1718}},
keywords = {{Artificial Gene Fusion; Chromosome Aberrations; Humans; Neoplasms; Journal Article; Research Support, Non-U.S. Gov't}},
language = {{eng}},
number = {{4}},
pages = {{331--334}},
publisher = {{Nature Publishing Group}},
series = {{Nature Genetics}},
title = {{Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer}},
url = {{https://lup.lub.lu.se/search/files/4571328/623988.pdf}},
doi = {{10.1038/ng1335}},
volume = {{36}},
year = {{2004}},
}