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Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer

Mitelman, Felix LU ; Johansson, Bertil LU and Mertens, Fredrik LU (2004) In Nature Genetics 36(4). p.331-334
Abstract

Cytogenetic aberrations have been reported in 45,000 human neoplasms. Structural balanced rearrangements are associated with distinct tumor subtypes with remarkable specificity and have been essential for identifying genes involved in tumorigenesis. All balanced rearrangements that have been characterized molecularly act by deregulating a gene in one of the breakpoints or by creating a fusion gene. Because most recurrent aberrations and rearranged genes have been found in hematological disorders, whereas numerous genomic imbalances have been identified in solid tumors, it has become generally accepted that there are pathogenetic differences between these neoplasms. We here show that in every tumor type, the numbers of recurrent balanced... (More)

Cytogenetic aberrations have been reported in 45,000 human neoplasms. Structural balanced rearrangements are associated with distinct tumor subtypes with remarkable specificity and have been essential for identifying genes involved in tumorigenesis. All balanced rearrangements that have been characterized molecularly act by deregulating a gene in one of the breakpoints or by creating a fusion gene. Because most recurrent aberrations and rearranged genes have been found in hematological disorders, whereas numerous genomic imbalances have been identified in solid tumors, it has become generally accepted that there are pathogenetic differences between these neoplasms. We here show that in every tumor type, the numbers of recurrent balanced chromosome abnormalities, fusion genes and genes rearranged as a consequence of balanced aberrations are simply a function of the number of cases with an abnormal karyotype. Hence, there may not be any fundamental tissue-specific differences in the genetic mechanisms by which neoplasia is initiated.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Artificial Gene Fusion, Chromosome Aberrations, Humans, Neoplasms, Journal Article, Research Support, Non-U.S. Gov't
in
Nature Genetics
volume
36
issue
4
pages
4 pages
publisher
Nature Publishing Group
external identifiers
  • wos:000220647200013
  • pmid:15054488
  • scopus:1842535882
ISSN
1546-1718
DOI
10.1038/ng1335
language
English
LU publication?
yes
id
73927d4e-d3d7-4ad0-be67-e920e3450044 (old id 121883)
date added to LUP
2007-07-09 08:05:08
date last changed
2017-11-05 04:27:06
@article{73927d4e-d3d7-4ad0-be67-e920e3450044,
  abstract     = {<p>Cytogenetic aberrations have been reported in 45,000 human neoplasms. Structural balanced rearrangements are associated with distinct tumor subtypes with remarkable specificity and have been essential for identifying genes involved in tumorigenesis. All balanced rearrangements that have been characterized molecularly act by deregulating a gene in one of the breakpoints or by creating a fusion gene. Because most recurrent aberrations and rearranged genes have been found in hematological disorders, whereas numerous genomic imbalances have been identified in solid tumors, it has become generally accepted that there are pathogenetic differences between these neoplasms. We here show that in every tumor type, the numbers of recurrent balanced chromosome abnormalities, fusion genes and genes rearranged as a consequence of balanced aberrations are simply a function of the number of cases with an abnormal karyotype. Hence, there may not be any fundamental tissue-specific differences in the genetic mechanisms by which neoplasia is initiated.</p>},
  author       = {Mitelman, Felix and Johansson, Bertil and Mertens, Fredrik},
  issn         = {1546-1718},
  keyword      = {Artificial Gene Fusion,Chromosome Aberrations,Humans,Neoplasms,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {4},
  pages        = {331--334},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer},
  url          = {http://dx.doi.org/10.1038/ng1335},
  volume       = {36},
  year         = {2004},
}