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Determinants of kidney function in Swedish families: role of heritable factors.

Fava, Cristiano LU ; Montagnana, Martina LU ; Burri, Philippe LU ; Almgren, Peter LU ; Minuz, Pietro; Hulthén, Lennart LU and Melander, Olle LU (2008) In Journal of Hypertension 26(9). p.1773-1779
Abstract
The aim of this study was to evaluate the determinants of kidney function and the role of heritable factors in a sample of 249 siblings free from known cardiovascular disease and without antihypertensive drugs belonging to 110 families. Four different measures and estimates of kidney function were considered. Blood pressure was recorded during 24 h by ambulatory blood pressure monitoring. Heritability was estimated with and without adjustment for significant covariates.In multivariate analysis, in addition to age, sex, BMI, HDL-cholesterol, 24-h systolic and mean blood pressure, systolic nocturnal blood pressure dipping resulted independently related to serum creatinine, estimated Cockcroft-Gault-creatinine clearance and estimated by the... (More)
The aim of this study was to evaluate the determinants of kidney function and the role of heritable factors in a sample of 249 siblings free from known cardiovascular disease and without antihypertensive drugs belonging to 110 families. Four different measures and estimates of kidney function were considered. Blood pressure was recorded during 24 h by ambulatory blood pressure monitoring. Heritability was estimated with and without adjustment for significant covariates.In multivariate analysis, in addition to age, sex, BMI, HDL-cholesterol, 24-h systolic and mean blood pressure, systolic nocturnal blood pressure dipping resulted independently related to serum creatinine, estimated Cockcroft-Gault-creatinine clearance and estimated by the modification of diet in renal disease-glomerular filtration rate. After full adjustment, the heritability values were 51% for the measured creatinine clearance (P < 0.01), 58% for the estimated Cockcroft-Gault-creatinine clearance (P < 0.001), 40% for the estimated by the modification of diet in renal disease-glomerular filtration rate (P < 0.001), but 8% (P = 0.34) for serum creatinine.Our data confirm that kidney function is partially under genetic control and that genetic variants of importance for this trait could be mapped. The association of the circadian rhythm of blood pressure with kidney function in this sample deserves further investigation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Hypertension
volume
26
issue
9
pages
1773 - 1779
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000259304900010
  • pmid:18698211
  • scopus:58149218408
ISSN
1473-5598
DOI
10.1097/HJH.0b013e3283060f1d
language
English
LU publication?
yes
id
7d13fc71-9805-467a-8cea-bed4948b3b55 (old id 1223258)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18698211?dopt=Abstract
date added to LUP
2008-09-02 13:38:18
date last changed
2017-01-01 06:14:40
@article{7d13fc71-9805-467a-8cea-bed4948b3b55,
  abstract     = {The aim of this study was to evaluate the determinants of kidney function and the role of heritable factors in a sample of 249 siblings free from known cardiovascular disease and without antihypertensive drugs belonging to 110 families. Four different measures and estimates of kidney function were considered. Blood pressure was recorded during 24 h by ambulatory blood pressure monitoring. Heritability was estimated with and without adjustment for significant covariates.In multivariate analysis, in addition to age, sex, BMI, HDL-cholesterol, 24-h systolic and mean blood pressure, systolic nocturnal blood pressure dipping resulted independently related to serum creatinine, estimated Cockcroft-Gault-creatinine clearance and estimated by the modification of diet in renal disease-glomerular filtration rate. After full adjustment, the heritability values were 51% for the measured creatinine clearance (P &lt; 0.01), 58% for the estimated Cockcroft-Gault-creatinine clearance (P &lt; 0.001), 40% for the estimated by the modification of diet in renal disease-glomerular filtration rate (P &lt; 0.001), but 8% (P = 0.34) for serum creatinine.Our data confirm that kidney function is partially under genetic control and that genetic variants of importance for this trait could be mapped. The association of the circadian rhythm of blood pressure with kidney function in this sample deserves further investigation.},
  author       = {Fava, Cristiano and Montagnana, Martina and Burri, Philippe and Almgren, Peter and Minuz, Pietro and Hulthén, Lennart and Melander, Olle},
  issn         = {1473-5598},
  language     = {eng},
  number       = {9},
  pages        = {1773--1779},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Hypertension},
  title        = {Determinants of kidney function in Swedish families: role of heritable factors.},
  url          = {http://dx.doi.org/10.1097/HJH.0b013e3283060f1d},
  volume       = {26},
  year         = {2008},
}