Determinants of kidney function in Swedish families: role of heritable factors.
Fava, Cristiano LU ; Montagnana, Martina LU ; Burri, Philippe LU ; Almgren, Peter LU ; Minuz, Pietro ; Hulthén, Lennart LU and Melander, Olle LU
(2008)
In Journal of Hypertension
26(9).
p.1773-1779
- Abstract
- The aim of this study was to evaluate the determinants of kidney function and the role of heritable factors in a sample of 249 siblings free from known cardiovascular disease and without antihypertensive drugs belonging to 110 families. Four different measures and estimates of kidney function were considered. Blood pressure was recorded during 24 h by ambulatory blood pressure monitoring. Heritability was estimated with and without adjustment for significant covariates.In multivariate analysis, in addition to age, sex, BMI, HDL-cholesterol, 24-h systolic and mean blood pressure, systolic nocturnal blood pressure dipping resulted independently related to serum creatinine, estimated Cockcroft-Gault-creatinine clearance and estimated by the... (More)
- The aim of this study was to evaluate the determinants of kidney function and the role of heritable factors in a sample of 249 siblings free from known cardiovascular disease and without antihypertensive drugs belonging to 110 families. Four different measures and estimates of kidney function were considered. Blood pressure was recorded during 24 h by ambulatory blood pressure monitoring. Heritability was estimated with and without adjustment for significant covariates.In multivariate analysis, in addition to age, sex, BMI, HDL-cholesterol, 24-h systolic and mean blood pressure, systolic nocturnal blood pressure dipping resulted independently related to serum creatinine, estimated Cockcroft-Gault-creatinine clearance and estimated by the modification of diet in renal disease-glomerular filtration rate. After full adjustment, the heritability values were 51% for the measured creatinine clearance (P < 0.01), 58% for the estimated Cockcroft-Gault-creatinine clearance (P < 0.001), 40% for the estimated by the modification of diet in renal disease-glomerular filtration rate (P < 0.001), but 8% (P = 0.34) for serum creatinine.Our data confirm that kidney function is partially under genetic control and that genetic variants of importance for this trait could be mapped. The association of the circadian rhythm of blood pressure with kidney function in this sample deserves further investigation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1223258
- author
- Fava, Cristiano
LU
; Montagnana, Martina
LU
; Burri, Philippe
LU
; Almgren, Peter
LU
; Minuz, Pietro
; Hulthén, Lennart
LU
and Melander, Olle
LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Hypertension
- volume
- 26
- issue
- 9
- pages
- 1773 - 1779
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000259304900010
- pmid:18698211
- scopus:58149218408
- pmid:18698211
- ISSN
- 1473-5598
- DOI
- 10.1097/HJH.0b013e3283060f1d
- language
- English
- LU publication?
- yes
- id
- 7d13fc71-9805-467a-8cea-bed4948b3b55 (old id 1223258)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18698211?dopt=Abstract
- date added to LUP
- 2016-04-01 14:26:02
- date last changed
- 2024-03-14 02:48:46
@article{7d13fc71-9805-467a-8cea-bed4948b3b55,
abstract = {{The aim of this study was to evaluate the determinants of kidney function and the role of heritable factors in a sample of 249 siblings free from known cardiovascular disease and without antihypertensive drugs belonging to 110 families. Four different measures and estimates of kidney function were considered. Blood pressure was recorded during 24 h by ambulatory blood pressure monitoring. Heritability was estimated with and without adjustment for significant covariates.In multivariate analysis, in addition to age, sex, BMI, HDL-cholesterol, 24-h systolic and mean blood pressure, systolic nocturnal blood pressure dipping resulted independently related to serum creatinine, estimated Cockcroft-Gault-creatinine clearance and estimated by the modification of diet in renal disease-glomerular filtration rate. After full adjustment, the heritability values were 51% for the measured creatinine clearance (P < 0.01), 58% for the estimated Cockcroft-Gault-creatinine clearance (P < 0.001), 40% for the estimated by the modification of diet in renal disease-glomerular filtration rate (P < 0.001), but 8% (P = 0.34) for serum creatinine.Our data confirm that kidney function is partially under genetic control and that genetic variants of importance for this trait could be mapped. The association of the circadian rhythm of blood pressure with kidney function in this sample deserves further investigation.}},
author = {{Fava, Cristiano and Montagnana, Martina and Burri, Philippe and Almgren, Peter and Minuz, Pietro and Hulthén, Lennart and Melander, Olle}},
issn = {{1473-5598}},
language = {{eng}},
number = {{9}},
pages = {{1773--1779}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Journal of Hypertension}},
title = {{Determinants of kidney function in Swedish families: role of heritable factors.}},
url = {{http://dx.doi.org/10.1097/HJH.0b013e3283060f1d}},
doi = {{10.1097/HJH.0b013e3283060f1d}},
volume = {{26}},
year = {{2008}},
}