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Impact of therapy and androgen receptor polymorphism on sperm concentration in men treated for testicular germ cell cancer: a longitudinal study.

Eberhard, Jakob LU ; Ståhl, Olof LU ; Giwercman, Yvonne LU ; Cwikiel, Magdalena LU ; Cavallin-Ståhl, Eva LU ; Lundin, Kristina LU ; Flodgren, Per LU and Giwercman, Aleksander LU (2004) In Human Reproduction 19(6). p.1418-1425
Abstract (Swedish)
Abstract in Undetermined

BACKGROUND: Testicular cancer (TC) patients have a high survival rate, and the question of post-therapy recovery of sperm production and its dependence on genetic predisposition is of major interest. METHODS: Ejaculates were obtained from 112 TC patients at one or more of the following time points: post-orchidectomy, or 6, 12, 24, 36 and 60 months post-therapy. The lengths of the androgen receptor (AR) function modulating CAG and GGN repeats in leukocyte DNA were also analysed. RESULTS: No significant decrease in sperm concentration was seen in men who received 1-2 cycles of adjuvant chemotherapy (ACT). Radiotherapy (RT) or more than two cycles of chemotherapy (HCT) caused an initial decline in... (More)
Abstract in Undetermined

BACKGROUND: Testicular cancer (TC) patients have a high survival rate, and the question of post-therapy recovery of sperm production and its dependence on genetic predisposition is of major interest. METHODS: Ejaculates were obtained from 112 TC patients at one or more of the following time points: post-orchidectomy, or 6, 12, 24, 36 and 60 months post-therapy. The lengths of the androgen receptor (AR) function modulating CAG and GGN repeats in leukocyte DNA were also analysed. RESULTS: No significant decrease in sperm concentration was seen in men who received 1-2 cycles of adjuvant chemotherapy (ACT). Radiotherapy (RT) or more than two cycles of chemotherapy (HCT) caused an initial decline in sperm concentration, which returned to pre-treatment levels 2-5 years after therapy. In the HCT group, sperm concentration 12-24 months post-treatment (T(12-24)) was inversely correlated with CAG length (rho = -0.72, P = 0.03). The type of treatment, but not the concentration at T(0), was an independent predictor of sperm concentration at T(6) (P < 0.0005) and T(12-24) (P = 0.004). CONCLUSION: ACT did not induce a significant decline in sperm concentration. After HCT and RT, a significant reduction of sperm concentration was observed, recovering to pre-treatment levels 2-5 years post-treatment. In HCT-treated patients, the AR CAG length influenced the recovery of spermatogenesis. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
androgen receptor/chemotherapy/radiotherapy/semen quality/testicular cancer
in
Human Reproduction
volume
19
issue
6
pages
1418 - 1425
publisher
Oxford University Press
external identifiers
  • wos:000221748200028
  • pmid:15105386
  • scopus:3042636786
ISSN
0268-1161
DOI
10.1093/humrep/deh231
language
English
LU publication?
yes
id
e6b95f6f-b6a3-4f85-a896-545b4cab2cc7 (old id 122423)
alternative location
http://humrep.oxfordjournals.org/cgi/content/abstract/19/6/1418
http://www.ncbi.nlm.nih.gov/pubmed/15105386
date added to LUP
2007-07-17 16:40:35
date last changed
2017-09-03 03:57:04
@article{e6b95f6f-b6a3-4f85-a896-545b4cab2cc7,
  abstract     = {<b>Abstract in Undetermined</b><br/><br>
BACKGROUND: Testicular cancer (TC) patients have a high survival rate, and the question of post-therapy recovery of sperm production and its dependence on genetic predisposition is of major interest. METHODS: Ejaculates were obtained from 112 TC patients at one or more of the following time points: post-orchidectomy, or 6, 12, 24, 36 and 60 months post-therapy. The lengths of the androgen receptor (AR) function modulating CAG and GGN repeats in leukocyte DNA were also analysed. RESULTS: No significant decrease in sperm concentration was seen in men who received 1-2 cycles of adjuvant chemotherapy (ACT). Radiotherapy (RT) or more than two cycles of chemotherapy (HCT) caused an initial decline in sperm concentration, which returned to pre-treatment levels 2-5 years after therapy. In the HCT group, sperm concentration 12-24 months post-treatment (T(12-24)) was inversely correlated with CAG length (rho = -0.72, P = 0.03). The type of treatment, but not the concentration at T(0), was an independent predictor of sperm concentration at T(6) (P &lt; 0.0005) and T(12-24) (P = 0.004). CONCLUSION: ACT did not induce a significant decline in sperm concentration. After HCT and RT, a significant reduction of sperm concentration was observed, recovering to pre-treatment levels 2-5 years post-treatment. In HCT-treated patients, the AR CAG length influenced the recovery of spermatogenesis.},
  author       = {Eberhard, Jakob and Ståhl, Olof and Giwercman, Yvonne and Cwikiel, Magdalena and Cavallin-Ståhl, Eva and Lundin, Kristina and Flodgren, Per and Giwercman, Aleksander},
  issn         = {0268-1161},
  keyword      = {androgen receptor/chemotherapy/radiotherapy/semen quality/testicular cancer},
  language     = {eng},
  number       = {6},
  pages        = {1418--1425},
  publisher    = {Oxford University Press},
  series       = {Human Reproduction},
  title        = {Impact of therapy and androgen receptor polymorphism on sperm concentration in men treated for testicular germ cell cancer: a longitudinal study.},
  url          = {http://dx.doi.org/10.1093/humrep/deh231},
  volume       = {19},
  year         = {2004},
}