Low umbilical artery vascular flow resistance and fetal outcome.
(2004) In Acta Obstetricia et Gynecologica Scandinavica 83(5). p.440442 Abstract
 Background. An abnormally high [above mean + 2 standard deviations (SD)] umbilical artery (UA) pulsatility index (PI) indicates impaired fetal outcome, whereas the impact of an "abnormally" low (below mean 2 SD) PI is unknown.
Methods. Perinatal outcome was compared between cases with a UA PI less than mean 2 SD (group A: highrisk cases selected from a database, n = 330; group B: unselected cases, n = 39) and unselected controls (group C) with a PI within mean ± 2 SD (n = 863) at Doppler velocimetry. Groups B and C were retrieved from a populationbased sample. The unpaired ttest, MannWhitney Utest, chi2test and Fisher's exact probability test were used for statistical comparisons with a twotailed p < 0.05... (More)  Background. An abnormally high [above mean + 2 standard deviations (SD)] umbilical artery (UA) pulsatility index (PI) indicates impaired fetal outcome, whereas the impact of an "abnormally" low (below mean 2 SD) PI is unknown.
Methods. Perinatal outcome was compared between cases with a UA PI less than mean 2 SD (group A: highrisk cases selected from a database, n = 330; group B: unselected cases, n = 39) and unselected controls (group C) with a PI within mean ± 2 SD (n = 863) at Doppler velocimetry. Groups B and C were retrieved from a populationbased sample. The unpaired ttest, MannWhitney Utest, chi2test and Fisher's exact probability test were used for statistical comparisons with a twotailed p < 0.05 being significant.
Results. No significant differences were found between group A vs. group C and group B vs. group C regarding perinatal mortality, Apgar scores at 1, 5 or 10 min, or arterial or venous cord blood pH. Postterm pregnancy in group A carried no additional risk. For obvious reasons, operative delivery and neonatal intensive care were more common in group A than in group C, but no such differences were found between groups B and C. The mean birthweight was 3.7% higher in group B than in group C (p = 0.049).
Conclusions. Deeming a UA PI below the lower reference limit as "abnormally" low is a statistical definition that was not reflected by a biological imperfection. Instead, a low UA PI promoted fetal growth. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/record/122893
 author
 Olofsson, Per ^{LU} ; Olofsson, Hanna; Molin, Johan ^{LU} and Marsal, Karel ^{LU}
 organization
 publishing date
 2004
 type
 Contribution to journal
 publication status
 published
 subject
 in
 Acta Obstetricia et Gynecologica Scandinavica
 volume
 83
 issue
 5
 pages
 440  442
 publisher
 WileyBlackwell
 external identifiers

 pmid:15059155
 wos:000221059400005
 scopus:2042444434
 ISSN
 16000412
 DOI
 10.1111/j.00016349.2004.00339.x
 language
 English
 LU publication?
 yes
 id
 72262e13534d4134ab89700179ad1bec (old id 122893)
 alternative location
 http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=15059155&dopt=Abstract
 date added to LUP
 20070718 10:58:57
 date last changed
 20170101 07:17:40
@article{72262e13534d4134ab89700179ad1bec, abstract = {Background. An abnormally high [above mean + 2 standard deviations (SD)] umbilical artery (UA) pulsatility index (PI) indicates impaired fetal outcome, whereas the impact of an "abnormally" low (below mean 2 SD) PI is unknown.<br/><br> <br/><br> Methods. Perinatal outcome was compared between cases with a UA PI less than mean 2 SD (group A: highrisk cases selected from a database, n = 330; group B: unselected cases, n = 39) and unselected controls (group C) with a PI within mean ± 2 SD (n = 863) at Doppler velocimetry. Groups B and C were retrieved from a populationbased sample. The unpaired ttest, MannWhitney Utest, chi2test and Fisher's exact probability test were used for statistical comparisons with a twotailed p < 0.05 being significant.<br/><br> <br/><br> Results. No significant differences were found between group A vs. group C and group B vs. group C regarding perinatal mortality, Apgar scores at 1, 5 or 10 min, or arterial or venous cord blood pH. Postterm pregnancy in group A carried no additional risk. For obvious reasons, operative delivery and neonatal intensive care were more common in group A than in group C, but no such differences were found between groups B and C. The mean birthweight was 3.7% higher in group B than in group C (p = 0.049).<br/><br> <br/><br> Conclusions. Deeming a UA PI below the lower reference limit as "abnormally" low is a statistical definition that was not reflected by a biological imperfection. Instead, a low UA PI promoted fetal growth.}, author = {Olofsson, Per and Olofsson, Hanna and Molin, Johan and Marsal, Karel}, issn = {16000412}, language = {eng}, number = {5}, pages = {440442}, publisher = {WileyBlackwell}, series = {Acta Obstetricia et Gynecologica Scandinavica}, title = {Low umbilical artery vascular flow resistance and fetal outcome.}, url = {http://dx.doi.org/10.1111/j.00016349.2004.00339.x}, volume = {83}, year = {2004}, }