Low umbilical artery vascular flow resistance and fetal outcome.
(2004) In Acta Obstetricia et Gynecologica Scandinavica 83(5). p.440-442- Abstract
- Background. An abnormally high [above mean + 2 standard deviations (SD)] umbilical artery (UA) pulsatility index (PI) indicates impaired fetal outcome, whereas the impact of an "abnormally" low (below mean -2 SD) PI is unknown.
Methods. Perinatal outcome was compared between cases with a UA PI less than mean -2 SD (group A: high-risk cases selected from a database, n = 330; group B: unselected cases, n = 39) and unselected controls (group C) with a PI within mean ± 2 SD (n = 863) at Doppler velocimetry. Groups B and C were retrieved from a population-based sample. The unpaired t-test, Mann-Whitney U-test, chi2-test and Fisher's exact probability test were used for statistical comparisons with a two-tailed p < 0.05... (More) - Background. An abnormally high [above mean + 2 standard deviations (SD)] umbilical artery (UA) pulsatility index (PI) indicates impaired fetal outcome, whereas the impact of an "abnormally" low (below mean -2 SD) PI is unknown.
Methods. Perinatal outcome was compared between cases with a UA PI less than mean -2 SD (group A: high-risk cases selected from a database, n = 330; group B: unselected cases, n = 39) and unselected controls (group C) with a PI within mean ± 2 SD (n = 863) at Doppler velocimetry. Groups B and C were retrieved from a population-based sample. The unpaired t-test, Mann-Whitney U-test, chi2-test and Fisher's exact probability test were used for statistical comparisons with a two-tailed p < 0.05 being significant.
Results. No significant differences were found between group A vs. group C and group B vs. group C regarding perinatal mortality, Apgar scores at 1, 5 or 10 min, or arterial or venous cord blood pH. Postterm pregnancy in group A carried no additional risk. For obvious reasons, operative delivery and neonatal intensive care were more common in group A than in group C, but no such differences were found between groups B and C. The mean birthweight was 3.7% higher in group B than in group C (p = 0.049).
Conclusions. Deeming a UA PI below the lower reference limit as "abnormally" low is a statistical definition that was not reflected by a biological imperfection. Instead, a low UA PI promoted fetal growth. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/122893
- author
- Olofsson, Per LU ; Olofsson, Hanna ; Molin, Johan LU and Marsal, Karel LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Obstetricia et Gynecologica Scandinavica
- volume
- 83
- issue
- 5
- pages
- 440 - 442
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:15059155
- wos:000221059400005
- scopus:2042444434
- ISSN
- 1600-0412
- DOI
- 10.1111/j.0001-6349.2004.00339.x
- language
- English
- LU publication?
- yes
- id
- 72262e13-534d-4134-ab89-700179ad1bec (old id 122893)
- alternative location
- http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=15059155&dopt=Abstract
- date added to LUP
- 2016-04-01 16:52:36
- date last changed
- 2022-01-28 22:44:55
@article{72262e13-534d-4134-ab89-700179ad1bec, abstract = {{Background. An abnormally high [above mean + 2 standard deviations (SD)] umbilical artery (UA) pulsatility index (PI) indicates impaired fetal outcome, whereas the impact of an "abnormally" low (below mean -2 SD) PI is unknown.<br/><br> <br/><br> Methods. Perinatal outcome was compared between cases with a UA PI less than mean -2 SD (group A: high-risk cases selected from a database, n = 330; group B: unselected cases, n = 39) and unselected controls (group C) with a PI within mean ± 2 SD (n = 863) at Doppler velocimetry. Groups B and C were retrieved from a population-based sample. The unpaired t-test, Mann-Whitney U-test, chi2-test and Fisher's exact probability test were used for statistical comparisons with a two-tailed p < 0.05 being significant.<br/><br> <br/><br> Results. No significant differences were found between group A vs. group C and group B vs. group C regarding perinatal mortality, Apgar scores at 1, 5 or 10 min, or arterial or venous cord blood pH. Postterm pregnancy in group A carried no additional risk. For obvious reasons, operative delivery and neonatal intensive care were more common in group A than in group C, but no such differences were found between groups B and C. The mean birthweight was 3.7% higher in group B than in group C (p = 0.049).<br/><br> <br/><br> Conclusions. Deeming a UA PI below the lower reference limit as "abnormally" low is a statistical definition that was not reflected by a biological imperfection. Instead, a low UA PI promoted fetal growth.}}, author = {{Olofsson, Per and Olofsson, Hanna and Molin, Johan and Marsal, Karel}}, issn = {{1600-0412}}, language = {{eng}}, number = {{5}}, pages = {{440--442}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Obstetricia et Gynecologica Scandinavica}}, title = {{Low umbilical artery vascular flow resistance and fetal outcome.}}, url = {{https://lup.lub.lu.se/search/files/4806729/623998.pdf}}, doi = {{10.1111/j.0001-6349.2004.00339.x}}, volume = {{83}}, year = {{2004}}, }