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Lung fractional moving blood volume in normally grown and growth restricted foetuses.

Hernandez-Andrade, Edgar LU ; Thuring, Ann LU ; Jansson, Tomas LU ; Lingman, Göran LU and Marsal, Karel LU (2004) In Clinical Physiology and Functional Imaging2002-01-01+01:00 24(2). p.69-74
Abstract
Objective: To examine foetal lung blood perfusion using power Doppler ultrasound (PDU) and to compare fractional moving blood volume (FMBV) and mean pixel intensity (MPI) estimations in the lungs of normally grown (NG) foetuses and foetuses with intrauterine growth restriction (IUGR) and also to correlate foetal lung FMBV and MPI with respiratory complications after birth.



Methods: Lungs of 47 NG and 25 IUGR foetuses after 32 weeks of gestation were examined with PDU. FMBV and MPI were estimated in a defined region in the posterior part of the foetal lung closest to maternal abdominal wall. FMBV and MPI were correlated to foetal weight deviation and gestational age. Perinatal outcome and respiratory complications after... (More)
Objective: To examine foetal lung blood perfusion using power Doppler ultrasound (PDU) and to compare fractional moving blood volume (FMBV) and mean pixel intensity (MPI) estimations in the lungs of normally grown (NG) foetuses and foetuses with intrauterine growth restriction (IUGR) and also to correlate foetal lung FMBV and MPI with respiratory complications after birth.



Methods: Lungs of 47 NG and 25 IUGR foetuses after 32 weeks of gestation were examined with PDU. FMBV and MPI were estimated in a defined region in the posterior part of the foetal lung closest to maternal abdominal wall. FMBV and MPI were correlated to foetal weight deviation and gestational age. Perinatal outcome and respiratory complications after birth were recorded in both groups.



Results: There were significantly lower FMBV and MPI values in IUGR than in NG foetuses. The overall variation was lower for FMBV than for MPI. There was a slightly higher correlation between FMBV and foetal weight deviation [r = 0·33, 95% confidence intervals (CI) 0·11-0·52] than between MPI and foetal weight deviation (r = 0·26, 95% CI 0·03-0·46). There was no significant correlation between FMBV or MPI and gestational age. No differences between the groups were found in the rate of respiratory complications, and they were not correlated either to the FMBV or MPI.



Conclusion: FMBV and MPI, estimated from the PDU signals of foetal lung circulation, showed lower values in third-trimester pregnancies complicated by IUGR. The frequency of neonatal respiratory complications was not increased in cases with low pulmonary FMBV and MPI values. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Physiology and Functional Imaging2002-01-01+01:00
volume
24
issue
2
pages
69 - 74
publisher
Wiley Online Library
external identifiers
  • wos:000220380900001
  • pmid:15056178
  • scopus:1842855288
ISSN
1475-0961
DOI
10.1111/j.1475-097X.2004.00532.x
language
English
LU publication?
yes
id
29607030-1dfd-49bd-bca9-89de5980bc2a (old id 122922)
date added to LUP
2007-07-18 08:44:41
date last changed
2017-01-01 04:40:30
@article{29607030-1dfd-49bd-bca9-89de5980bc2a,
  abstract     = {Objective: To examine foetal lung blood perfusion using power Doppler ultrasound (PDU) and to compare fractional moving blood volume (FMBV) and mean pixel intensity (MPI) estimations in the lungs of normally grown (NG) foetuses and foetuses with intrauterine growth restriction (IUGR) and also to correlate foetal lung FMBV and MPI with respiratory complications after birth.<br/><br>
<br/><br>
Methods: Lungs of 47 NG and 25 IUGR foetuses after 32 weeks of gestation were examined with PDU. FMBV and MPI were estimated in a defined region in the posterior part of the foetal lung closest to maternal abdominal wall. FMBV and MPI were correlated to foetal weight deviation and gestational age. Perinatal outcome and respiratory complications after birth were recorded in both groups.<br/><br>
<br/><br>
Results: There were significantly lower FMBV and MPI values in IUGR than in NG foetuses. The overall variation was lower for FMBV than for MPI. There was a slightly higher correlation between FMBV and foetal weight deviation [r = 0·33, 95% confidence intervals (CI) 0·11-0·52] than between MPI and foetal weight deviation (r = 0·26, 95% CI 0·03-0·46). There was no significant correlation between FMBV or MPI and gestational age. No differences between the groups were found in the rate of respiratory complications, and they were not correlated either to the FMBV or MPI.<br/><br>
<br/><br>
Conclusion: FMBV and MPI, estimated from the PDU signals of foetal lung circulation, showed lower values in third-trimester pregnancies complicated by IUGR. The frequency of neonatal respiratory complications was not increased in cases with low pulmonary FMBV and MPI values.},
  author       = {Hernandez-Andrade, Edgar and Thuring, Ann and Jansson, Tomas and Lingman, Göran and Marsal, Karel},
  issn         = {1475-0961},
  language     = {eng},
  number       = {2},
  pages        = {69--74},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology and Functional Imaging2002-01-01+01:00},
  title        = {Lung fractional moving blood volume in normally grown and growth restricted foetuses.},
  url          = {http://dx.doi.org/10.1111/j.1475-097X.2004.00532.x},
  volume       = {24},
  year         = {2004},
}