Exposure to transportation noise and risk for cardiovascular disease in a nationwide cohort study from Denmark
(2022) In Environmental Research 211. p.1-9- Abstract
BACKGROUND: Transportation noise increases the risk of ischemic heart disease (IHD), but few studies have investigated subtypes of IHD, such as myocardial infarction (MI), angina pectoris, or heart failure. We aimed to study whether exposure to road, railway and aircraft noise increased risk for ischemic heart disease (IHD), IHD subtypes, and heart failure in the entire adult Danish population, investigating exposures at both maximum exposed and silent façades of each residence.
METHODS: We modelled road, railway, and aircraft noise at the most and least exposed façades for the period 1995-2017 for all addresses in Denmark and calculated 10-year time-weighted running means for 2.5 million individuals age ≥50 years, of whom 122,523... (More)
BACKGROUND: Transportation noise increases the risk of ischemic heart disease (IHD), but few studies have investigated subtypes of IHD, such as myocardial infarction (MI), angina pectoris, or heart failure. We aimed to study whether exposure to road, railway and aircraft noise increased risk for ischemic heart disease (IHD), IHD subtypes, and heart failure in the entire adult Danish population, investigating exposures at both maximum exposed and silent façades of each residence.
METHODS: We modelled road, railway, and aircraft noise at the most and least exposed façades for the period 1995-2017 for all addresses in Denmark and calculated 10-year time-weighted running means for 2.5 million individuals age ≥50 years, of whom 122,523 developed IHD and 79,358 developed heart failure during follow-up (2005-2017). Data were analyzed using Cox proportional hazards models, adjusted for individual and area-level sociodemographic covariates and air pollution.
RESULTS: We found road traffic noise at the most exposed façade (Lden) to be associated with higher risk of IHD, myocardial infarction (MI), angina pectoris, and heart failure, with hazard ratios (HRs) (95% confidence intervals (CI)) of 1.052 (1.044-1.059), 1.041 (1.032-1.051), 1.095 (1.071-1.119), and 1.039 (1.033-1.045) per 10 dB higher 10-year mean exposure, respectively. These associations followed a near-linear exposure-response relationship and were robust to adjustment for air pollution with PM2.5. Railway noise at the least exposed façade was associated with heart failure (HR 1.28; 95% CI: 1.004-1.053), but not the other outcomes. Exposure to aircraft noise (>45 dB) seemed associated with increased risk for MI and heart failure.
CONCLUSIONS: We found road traffic noise and potentially railway and aircraft noise to increase risk of various major cardiovascular outcomes, highlighting the importance of preventive actions towards transportation noise.
(Less)
- author
- Thacher, Jesse D LU ; Poulsen, Aslak H ; Raaschou-Nielsen, Ole ; Hvidtfeldt, Ulla A ; Brandt, Jørgen ; Christensen, Jesper H ; Khan, Jibran ; Levin, Gregor ; Münzel, Thomas and Sørensen, Mette
- publishing date
- 2022-08
- type
- Contribution to journal
- publication status
- published
- keywords
- Adult, Angina Pectoris, Cardiovascular Diseases/epidemiology, Cohort Studies, Denmark/epidemiology, Environmental Exposure, Heart Failure, Humans, Middle Aged, Myocardial Infarction/epidemiology, Myocardial Ischemia, Noise, Transportation/adverse effects
- in
- Environmental Research
- volume
- 211
- article number
- 113106
- pages
- 1 - 9
- publisher
- Elsevier
- external identifiers
-
- scopus:85126510881
- pmid:35304113
- ISSN
- 1096-0953
- DOI
- 10.1016/j.envres.2022.113106
- language
- English
- LU publication?
- no
- additional info
- Copyright © 2022 Elsevier Inc. All rights reserved.
- id
- 122b46fa-d637-4fa5-bb1c-109fc29f62ac
- date added to LUP
- 2023-05-08 10:22:45
- date last changed
- 2024-04-19 21:35:33
@article{122b46fa-d637-4fa5-bb1c-109fc29f62ac,
abstract = {{<p>BACKGROUND: Transportation noise increases the risk of ischemic heart disease (IHD), but few studies have investigated subtypes of IHD, such as myocardial infarction (MI), angina pectoris, or heart failure. We aimed to study whether exposure to road, railway and aircraft noise increased risk for ischemic heart disease (IHD), IHD subtypes, and heart failure in the entire adult Danish population, investigating exposures at both maximum exposed and silent façades of each residence.</p><p>METHODS: We modelled road, railway, and aircraft noise at the most and least exposed façades for the period 1995-2017 for all addresses in Denmark and calculated 10-year time-weighted running means for 2.5 million individuals age ≥50 years, of whom 122,523 developed IHD and 79,358 developed heart failure during follow-up (2005-2017). Data were analyzed using Cox proportional hazards models, adjusted for individual and area-level sociodemographic covariates and air pollution.</p><p>RESULTS: We found road traffic noise at the most exposed façade (Lden) to be associated with higher risk of IHD, myocardial infarction (MI), angina pectoris, and heart failure, with hazard ratios (HRs) (95% confidence intervals (CI)) of 1.052 (1.044-1.059), 1.041 (1.032-1.051), 1.095 (1.071-1.119), and 1.039 (1.033-1.045) per 10 dB higher 10-year mean exposure, respectively. These associations followed a near-linear exposure-response relationship and were robust to adjustment for air pollution with PM2.5. Railway noise at the least exposed façade was associated with heart failure (HR 1.28; 95% CI: 1.004-1.053), but not the other outcomes. Exposure to aircraft noise (>45 dB) seemed associated with increased risk for MI and heart failure.</p><p>CONCLUSIONS: We found road traffic noise and potentially railway and aircraft noise to increase risk of various major cardiovascular outcomes, highlighting the importance of preventive actions towards transportation noise.</p>}},
author = {{Thacher, Jesse D and Poulsen, Aslak H and Raaschou-Nielsen, Ole and Hvidtfeldt, Ulla A and Brandt, Jørgen and Christensen, Jesper H and Khan, Jibran and Levin, Gregor and Münzel, Thomas and Sørensen, Mette}},
issn = {{1096-0953}},
keywords = {{Adult; Angina Pectoris; Cardiovascular Diseases/epidemiology; Cohort Studies; Denmark/epidemiology; Environmental Exposure; Heart Failure; Humans; Middle Aged; Myocardial Infarction/epidemiology; Myocardial Ischemia; Noise, Transportation/adverse effects}},
language = {{eng}},
pages = {{1--9}},
publisher = {{Elsevier}},
series = {{Environmental Research}},
title = {{Exposure to transportation noise and risk for cardiovascular disease in a nationwide cohort study from Denmark}},
url = {{http://dx.doi.org/10.1016/j.envres.2022.113106}},
doi = {{10.1016/j.envres.2022.113106}},
volume = {{211}},
year = {{2022}},
}