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No evidence for new dopaminergic neurons in the adult mammalian substantia nigra.

Frielingsdorf, Helena LU ; Schwarz, Katherine; Brundin, Patrik LU and Mohapel, Paul LU (2004) In Proceedings of the National Academy of Sciences 101(27). p.10177-10182
Abstract
A recent report by Zhao et al. [Zhao, M., Momma, S., Delfani, K., Carlen, M., Cassidy, R. M., Johansson, C. B., Brismar, H., Shupliakov, O., Frisen, J. & Janson, A. M. (2003) Proc. Natl. Acad. Sci. USA 100, 7925–7930] suggests that dopaminergic neurons, the cell type lost in Parkinson's disease, are continuously generated in the adult substantia nigra pars compacta. Using similar methodological procedures to label dividing cells, we found no evidence of new dopaminergic neurons in the substantia nigra, either in normal or 6-hydroxydopamine-lesioned hemi-Parkinsonian rodents, or even after growth factor treatment. Furthermore, we found no evidence of neural stem cells emanating from the cerebroventricular system and migrating to the... (More)
A recent report by Zhao et al. [Zhao, M., Momma, S., Delfani, K., Carlen, M., Cassidy, R. M., Johansson, C. B., Brismar, H., Shupliakov, O., Frisen, J. & Janson, A. M. (2003) Proc. Natl. Acad. Sci. USA 100, 7925–7930] suggests that dopaminergic neurons, the cell type lost in Parkinson's disease, are continuously generated in the adult substantia nigra pars compacta. Using similar methodological procedures to label dividing cells, we found no evidence of new dopaminergic neurons in the substantia nigra, either in normal or 6-hydroxydopamine-lesioned hemi-Parkinsonian rodents, or even after growth factor treatment. Furthermore, we found no evidence of neural stem cells emanating from the cerebroventricular system and migrating to the substantia nigra. We conclude that it is unlikely that dopaminergic neurons are generated in the adult mammalian substantia nigra. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Proceedings of the National Academy of Sciences
volume
101
issue
27
pages
10177 - 10182
publisher
National Acad Sciences
external identifiers
  • wos:000222534200043
  • scopus:3042829625
ISSN
1091-6490
DOI
10.1073/pnas.0401229101
language
English
LU publication?
yes
id
9a1e8230-bad0-4a95-98e7-b9c81f6959a7 (old id 123993)
date added to LUP
2007-07-12 11:58:52
date last changed
2017-10-22 03:32:55
@article{9a1e8230-bad0-4a95-98e7-b9c81f6959a7,
  abstract     = {A recent report by Zhao et al. [Zhao, M., Momma, S., Delfani, K., Carlen, M., Cassidy, R. M., Johansson, C. B., Brismar, H., Shupliakov, O., Frisen, J. & Janson, A. M. (2003) Proc. Natl. Acad. Sci. USA 100, 7925–7930] suggests that dopaminergic neurons, the cell type lost in Parkinson's disease, are continuously generated in the adult substantia nigra pars compacta. Using similar methodological procedures to label dividing cells, we found no evidence of new dopaminergic neurons in the substantia nigra, either in normal or 6-hydroxydopamine-lesioned hemi-Parkinsonian rodents, or even after growth factor treatment. Furthermore, we found no evidence of neural stem cells emanating from the cerebroventricular system and migrating to the substantia nigra. We conclude that it is unlikely that dopaminergic neurons are generated in the adult mammalian substantia nigra.},
  author       = {Frielingsdorf, Helena and Schwarz, Katherine and Brundin, Patrik and Mohapel, Paul},
  issn         = {1091-6490},
  language     = {eng},
  number       = {27},
  pages        = {10177--10182},
  publisher    = {National Acad Sciences},
  series       = {Proceedings of the National Academy of Sciences},
  title        = {No evidence for new dopaminergic neurons in the adult mammalian substantia nigra.},
  url          = {http://dx.doi.org/10.1073/pnas.0401229101},
  volume       = {101},
  year         = {2004},
}