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Depression in the Lundby Study 1947-1997 Incidence, course and risk-factors

Mattisson, Cecilia LU (2008) In Lund University Faculty of Medicine Doctoral Dissertation Series 2008:87.
Abstract
Abstract



The aims of this thesis were to describe methodological problems, incidence and course of depressive disorders as well as possible risk factors for depression within the framework of the Lundby Study.



The Lundby population was investigated in 1947, 1957, 1972 and 1997. In 1947 the population consisted of 2550 subjects and in 1957, 1013 were added. The total population consists of 3563 subjects. Attrition rate for the field-investigations, 1947, 1957 and 1972 was 1-2% and in 1997 6%.



During the follow-up period the Lundby study had encountered many methodological problems such as changing diagnostic systems, recall bias, low interrater-reliability over time, migration and... (More)
Abstract



The aims of this thesis were to describe methodological problems, incidence and course of depressive disorders as well as possible risk factors for depression within the framework of the Lundby Study.



The Lundby population was investigated in 1947, 1957, 1972 and 1997. In 1947 the population consisted of 2550 subjects and in 1957, 1013 were added. The total population consists of 3563 subjects. Attrition rate for the field-investigations, 1947, 1957 and 1972 was 1-2% and in 1997 6%.



During the follow-up period the Lundby study had encountered many methodological problems such as changing diagnostic systems, recall bias, low interrater-reliability over time, migration and attrition. Low attrition rate over 50 years and reasonable diagnostic uniformity justify comparisons over time.



Incidence of depression was compared for the two time periods 1947-1972 and 1972-1997. Females had higher incidence rates than males in both periods. In the period 1972-1997 the average annual incidence rate was lower for females and tended to be lower for males as compared with 1947-1972.



The course of depression was followed for 344 subjects that had experienced an episode of first incidence depression during follow-up. The recurrence rate was about 40 % . Changes to other diagnoses were registered in 21% of the this sample, alcohol disorders in 7 % and bipolar disorders in 2 %. Five percent committed suicide; male gender and severity of depression were significant risk factors.



Risk factors for the whole sample and for the genders separately were analyzed for the cohorts1947 and 1957. For the 1947 cohort the personality trait nervous/tense was a risk factor for both genders in univariate analyses as well as in the multivariate analyses. Prior anxiety disorders, tiredness disorder, alcohol disorder and subvalidity appeared to be risk factors, especially for males in univariate analyses. In the multivariate model a risk factor for males was child neurosis and for females the personality trait abnormal/antisocial.



In univariate and multivariate analyses of the 1957 the cohort, the risk factors anxiety disorders, alcohol disorders and childneurosis were risk factors for males. For females the personality traits nervous/tense, abnormal/antisocial, tired/distracted, easily hurt and anxiety disorders were risk factors. In multivariate analyses the personality traits nervous/tense and abnormal/antisocial turned out as risk-factors for females. (Less)
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author
supervisor
opponent
  • professor Åsberg, Marie, Karolinska Institutet
organization
publishing date
type
Thesis
publication status
published
subject
keywords
depressive disorder, the Lundby Study, first incidence, course, risk-factors, Epdemiology, Methodology
in
Lund University Faculty of Medicine Doctoral Dissertation Series
volume
2008:87
pages
117 pages
publisher
Department of Clinical Sciences, Lund University
defense location
Wigerthuset, Klinikgatan 22 Stora föreläsningssalen Universitetssjukhuset i Lund
defense date
2008-10-31 09:00
ISSN
1652-8220
ISBN
1652-8220 978-91-86059-40-8
project
Lundby Project
language
English
LU publication?
yes
id
d070fb14-5a67-472b-9b72-86fd0be8fe08 (old id 1240802)
date added to LUP
2008-10-14 14:44:44
date last changed
2016-09-19 08:44:48
@phdthesis{d070fb14-5a67-472b-9b72-86fd0be8fe08,
  abstract     = {Abstract<br/><br>
<br/><br>
The aims of this thesis were to describe methodological problems, incidence and course of depressive disorders as well as possible risk factors for depression within the framework of the Lundby Study.<br/><br>
<br/><br>
The Lundby population was investigated in 1947, 1957, 1972 and 1997. In 1947 the population consisted of 2550 subjects and in 1957, 1013 were added. The total population consists of 3563 subjects. Attrition rate for the field-investigations, 1947, 1957 and 1972 was 1-2% and in 1997 6%.<br/><br>
<br/><br>
During the follow-up period the Lundby study had encountered many methodological problems such as changing diagnostic systems, recall bias, low interrater-reliability over time, migration and attrition. Low attrition rate over 50 years and reasonable diagnostic uniformity justify comparisons over time.<br/><br>
<br/><br>
Incidence of depression was compared for the two time periods 1947-1972 and 1972-1997. Females had higher incidence rates than males in both periods. In the period 1972-1997 the average annual incidence rate was lower for females and tended to be lower for males as compared with 1947-1972.<br/><br>
<br/><br>
The course of depression was followed for 344 subjects that had experienced an episode of first incidence depression during follow-up. The recurrence rate was about 40 % . Changes to other diagnoses were registered in 21% of the this sample, alcohol disorders in 7 % and bipolar disorders in 2 %. Five percent committed suicide; male gender and severity of depression were significant risk factors. <br/><br>
<br/><br>
Risk factors for the whole sample and for the genders separately were analyzed for the cohorts1947 and 1957. For the 1947 cohort the personality trait nervous/tense was a risk factor for both genders in univariate analyses as well as in the multivariate analyses. Prior anxiety disorders, tiredness disorder, alcohol disorder and subvalidity appeared to be risk factors, especially for males in univariate analyses. In the multivariate model a risk factor for males was child neurosis and for females the personality trait abnormal/antisocial. <br/><br>
<br/><br>
In univariate and multivariate analyses of the 1957 the cohort, the risk factors anxiety disorders, alcohol disorders and childneurosis were risk factors for males. For females the personality traits nervous/tense, abnormal/antisocial, tired/distracted, easily hurt and anxiety disorders were risk factors. In multivariate analyses the personality traits nervous/tense and abnormal/antisocial turned out as risk-factors for females.},
  author       = {Mattisson, Cecilia},
  isbn         = {1652-8220 978-91-86059-40-8},
  issn         = {1652-8220},
  keyword      = {depressive disorder,the Lundby Study,first incidence,course,risk-factors,Epdemiology,Methodology},
  language     = {eng},
  pages        = {117},
  publisher    = {Department of Clinical Sciences, Lund University},
  school       = {Lund University},
  series       = {Lund University Faculty of Medicine Doctoral Dissertation Series},
  title        = {Depression in the Lundby Study 1947-1997 Incidence, course and risk-factors},
  volume       = {2008:87},
  year         = {2008},
}