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Identification of a novel protein promoting the colonization and survival of Finegoldia magna, a bacterial commensal and opportunistic pathogen.

Frick, Inga-Maria LU ; Karlsson, Christofer LU ; Mörgelin, Matthias LU ; Olin, Anders I; Janjusevic, Radmila; Hammarström, Clara; Holst, Elisabet LU ; de Château, Maarten and Björck, Lars LU (2008) In Molecular Microbiology 70. p.695-708
Abstract
Anaerobic bacteria dominate the human normal microbiota but strikingly little is known about these commensals. Finegoldia magna is a Gram-positive anaerobe found in the skin and at other non-sterile body surfaces, but it is also an opportunistic pathogen. This study describes a novel protein designated FAF (F. magnaAdhesion Factor) and expressed by more than ninety percent of F. magna isolates. The protein is present in substantial quantities at the F.magna surface but is also released from the surface. FAF forms large protein aggregates in solution and surface-associated FAF causes bacterial clumping. In skin F. magna bacteria were localized to the epidermis, where they adhere to basement membranes. FAF was found to mediate this adhesion... (More)
Anaerobic bacteria dominate the human normal microbiota but strikingly little is known about these commensals. Finegoldia magna is a Gram-positive anaerobe found in the skin and at other non-sterile body surfaces, but it is also an opportunistic pathogen. This study describes a novel protein designated FAF (F. magnaAdhesion Factor) and expressed by more than ninety percent of F. magna isolates. The protein is present in substantial quantities at the F.magna surface but is also released from the surface. FAF forms large protein aggregates in solution and surface-associated FAF causes bacterial clumping. In skin F. magna bacteria were localized to the epidermis, where they adhere to basement membranes. FAF was found to mediate this adhesion via interactions with BM-40, a basement membrane protein. The biological significance of FAF is further underlined by the observation that it blocks the activity of LL-37, a major human antibacterial peptide. Altogether, the data demonstrate that FAF plays an important role in colonization and survival of F. magna in the human host. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Molecular Microbiology
volume
70
pages
695 - 708
publisher
Wiley-Blackwell
external identifiers
  • wos:000262305000013
  • pmid:18808384
  • scopus:53849108792
ISSN
1365-2958
DOI
10.1111/j.1365-2958.2008.06439.x
language
English
LU publication?
yes
id
da7e78b7-18ed-4ee7-ac25-84794ad51eef (old id 1242767)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18808384?dopt=Abstract
date added to LUP
2008-10-03 16:22:10
date last changed
2017-01-01 07:40:40
@article{da7e78b7-18ed-4ee7-ac25-84794ad51eef,
  abstract     = {Anaerobic bacteria dominate the human normal microbiota but strikingly little is known about these commensals. Finegoldia magna is a Gram-positive anaerobe found in the skin and at other non-sterile body surfaces, but it is also an opportunistic pathogen. This study describes a novel protein designated FAF (F. magnaAdhesion Factor) and expressed by more than ninety percent of F. magna isolates. The protein is present in substantial quantities at the F.magna surface but is also released from the surface. FAF forms large protein aggregates in solution and surface-associated FAF causes bacterial clumping. In skin F. magna bacteria were localized to the epidermis, where they adhere to basement membranes. FAF was found to mediate this adhesion via interactions with BM-40, a basement membrane protein. The biological significance of FAF is further underlined by the observation that it blocks the activity of LL-37, a major human antibacterial peptide. Altogether, the data demonstrate that FAF plays an important role in colonization and survival of F. magna in the human host.},
  author       = {Frick, Inga-Maria and Karlsson, Christofer and Mörgelin, Matthias and Olin, Anders I and Janjusevic, Radmila and Hammarström, Clara and Holst, Elisabet and de Château, Maarten and Björck, Lars},
  issn         = {1365-2958},
  language     = {eng},
  pages        = {695--708},
  publisher    = {Wiley-Blackwell},
  series       = {Molecular Microbiology},
  title        = {Identification of a novel protein promoting the colonization and survival of Finegoldia magna, a bacterial commensal and opportunistic pathogen.},
  url          = {http://dx.doi.org/10.1111/j.1365-2958.2008.06439.x},
  volume       = {70},
  year         = {2008},
}