Sympathetic and sensory nerve activation during negative pressure therapy of sternotomy wounds.
Torbrand, Christian LU ; Wackenfors, Angelica LU ; Lindstedt Ingemansson, Sandra LU ; Ekman, Rolf ; Ingemansson, Richard LU and Malmsjö, Malin LU
(2008)
In Interactive Cardiovascular and Thoracic Surgery
7(6).
p.1067-1070
- Abstract
- Negative pressure wound therapy (NPWT) has been adopted as the first-line treatment for poststernotomy mediastinitis as a result of the excellent clinical outcome. The knowledge concerning the effects of NPWT on the cardiovascular system and homeostasis is still limited. The aim of the present study was to investigate whether the plasma levels of neurohormones change during NPWT. Six pigs underwent median sternotomy followed by NPWT at -125 mmHg. The plasma levels of noradrenaline, adrenaline, neuropeptide Y, substance P, vasoactive intestinal peptide (VIP), and calcitonin gene-related peptide (CGRP) were determined before (0 min) and 5, 20, 60 and 180 min after the application of NPWT. The results show a transient increase in the plasma... (More)
- Negative pressure wound therapy (NPWT) has been adopted as the first-line treatment for poststernotomy mediastinitis as a result of the excellent clinical outcome. The knowledge concerning the effects of NPWT on the cardiovascular system and homeostasis is still limited. The aim of the present study was to investigate whether the plasma levels of neurohormones change during NPWT. Six pigs underwent median sternotomy followed by NPWT at -125 mmHg. The plasma levels of noradrenaline, adrenaline, neuropeptide Y, substance P, vasoactive intestinal peptide (VIP), and calcitonin gene-related peptide (CGRP) were determined before (0 min) and 5, 20, 60 and 180 min after the application of NPWT. The results show a transient increase in the plasma levels of noradrenaline and adrenaline when NPWT was applied. The plasma level of the adrenergic co-transmitter neuropeptide Y was higher in NPWT - than in sham-treated pigs, after 180 min of negative pressure. After 180 min of NPWT there was an increase in the plasma levels of the sensory nerve transmitter substance P, while no such effect was observed for CGRP or VIP. In conclusion, the results suggest sympathetic nerve activation during NPWT. This may be the result of an increase in workload on the heart during the initial phase of NPWT. Keywords: Experimental surgery; Mediastinal infection; Wound healing; Noradrenaline; Adrenaline. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1243146
- author
- Torbrand, Christian
LU
; Wackenfors, Angelica
LU
; Lindstedt Ingemansson, Sandra
LU
; Ekman, Rolf
; Ingemansson, Richard
LU
and Malmsjö, Malin
LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- mediastinal infection, experimental surgery, wound healing, noradrenaline, adrenaline
- in
- Interactive Cardiovascular and Thoracic Surgery
- volume
- 7
- issue
- 6
- pages
- 1067 - 1070
- publisher
- European Association of Cardio-Thoracic Surgery
- external identifiers
-
- pmid:18784122
- scopus:57349100838
- pmid:18784122
- ISSN
- 1569-9285
- DOI
- 10.1510/icvts.2008.181792
- language
- English
- LU publication?
- yes
- id
- 3fc64908-43a5-40f4-8059-7daf87437363 (old id 1243146)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18784122?dopt=Abstract
- date added to LUP
- 2016-04-04 07:17:23
- date last changed
- 2024-12-07 19:37:43
@article{3fc64908-43a5-40f4-8059-7daf87437363,
abstract = {{Negative pressure wound therapy (NPWT) has been adopted as the first-line treatment for poststernotomy mediastinitis as a result of the excellent clinical outcome. The knowledge concerning the effects of NPWT on the cardiovascular system and homeostasis is still limited. The aim of the present study was to investigate whether the plasma levels of neurohormones change during NPWT. Six pigs underwent median sternotomy followed by NPWT at -125 mmHg. The plasma levels of noradrenaline, adrenaline, neuropeptide Y, substance P, vasoactive intestinal peptide (VIP), and calcitonin gene-related peptide (CGRP) were determined before (0 min) and 5, 20, 60 and 180 min after the application of NPWT. The results show a transient increase in the plasma levels of noradrenaline and adrenaline when NPWT was applied. The plasma level of the adrenergic co-transmitter neuropeptide Y was higher in NPWT - than in sham-treated pigs, after 180 min of negative pressure. After 180 min of NPWT there was an increase in the plasma levels of the sensory nerve transmitter substance P, while no such effect was observed for CGRP or VIP. In conclusion, the results suggest sympathetic nerve activation during NPWT. This may be the result of an increase in workload on the heart during the initial phase of NPWT. Keywords: Experimental surgery; Mediastinal infection; Wound healing; Noradrenaline; Adrenaline.}},
author = {{Torbrand, Christian and Wackenfors, Angelica and Lindstedt Ingemansson, Sandra and Ekman, Rolf and Ingemansson, Richard and Malmsjö, Malin}},
issn = {{1569-9285}},
keywords = {{mediastinal infection; experimental surgery; wound healing; noradrenaline; adrenaline}},
language = {{eng}},
number = {{6}},
pages = {{1067--1070}},
publisher = {{European Association of Cardio-Thoracic Surgery}},
series = {{Interactive Cardiovascular and Thoracic Surgery}},
title = {{Sympathetic and sensory nerve activation during negative pressure therapy of sternotomy wounds.}},
url = {{http://dx.doi.org/10.1510/icvts.2008.181792}},
doi = {{10.1510/icvts.2008.181792}},
volume = {{7}},
year = {{2008}},
}