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Sympathetic and sensory nerve activation during negative pressure therapy of sternotomy wounds.

Torbrand, Christian LU ; Wackenfors, Angelica LU ; Lindstedt Ingemansson, Sandra LU ; Ekman, Rolf; Ingemansson, Richard LU and Malmsjö, Malin LU (2008) In Interactive Cardiovascular and Thoracic Surgery 7(6). p.1067-1070
Abstract
Negative pressure wound therapy (NPWT) has been adopted as the first-line treatment for poststernotomy mediastinitis as a result of the excellent clinical outcome. The knowledge concerning the effects of NPWT on the cardiovascular system and homeostasis is still limited. The aim of the present study was to investigate whether the plasma levels of neurohormones change during NPWT. Six pigs underwent median sternotomy followed by NPWT at -125 mmHg. The plasma levels of noradrenaline, adrenaline, neuropeptide Y, substance P, vasoactive intestinal peptide (VIP), and calcitonin gene-related peptide (CGRP) were determined before (0 min) and 5, 20, 60 and 180 min after the application of NPWT. The results show a transient increase in the plasma... (More)
Negative pressure wound therapy (NPWT) has been adopted as the first-line treatment for poststernotomy mediastinitis as a result of the excellent clinical outcome. The knowledge concerning the effects of NPWT on the cardiovascular system and homeostasis is still limited. The aim of the present study was to investigate whether the plasma levels of neurohormones change during NPWT. Six pigs underwent median sternotomy followed by NPWT at -125 mmHg. The plasma levels of noradrenaline, adrenaline, neuropeptide Y, substance P, vasoactive intestinal peptide (VIP), and calcitonin gene-related peptide (CGRP) were determined before (0 min) and 5, 20, 60 and 180 min after the application of NPWT. The results show a transient increase in the plasma levels of noradrenaline and adrenaline when NPWT was applied. The plasma level of the adrenergic co-transmitter neuropeptide Y was higher in NPWT - than in sham-treated pigs, after 180 min of negative pressure. After 180 min of NPWT there was an increase in the plasma levels of the sensory nerve transmitter substance P, while no such effect was observed for CGRP or VIP. In conclusion, the results suggest sympathetic nerve activation during NPWT. This may be the result of an increase in workload on the heart during the initial phase of NPWT. Keywords: Experimental surgery; Mediastinal infection; Wound healing; Noradrenaline; Adrenaline. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
mediastinal infection, experimental surgery, wound healing, noradrenaline, adrenaline
in
Interactive Cardiovascular and Thoracic Surgery
volume
7
issue
6
pages
1067 - 1070
publisher
European Association of Cardio-Thoracic Surgery
external identifiers
  • pmid:18784122
  • scopus:57349100838
ISSN
1569-9285
DOI
10.1510/icvts.2008.181792
language
English
LU publication?
yes
id
3fc64908-43a5-40f4-8059-7daf87437363 (old id 1243146)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18784122?dopt=Abstract
date added to LUP
2008-10-07 13:49:06
date last changed
2017-05-28 04:31:48
@article{3fc64908-43a5-40f4-8059-7daf87437363,
  abstract     = {Negative pressure wound therapy (NPWT) has been adopted as the first-line treatment for poststernotomy mediastinitis as a result of the excellent clinical outcome. The knowledge concerning the effects of NPWT on the cardiovascular system and homeostasis is still limited. The aim of the present study was to investigate whether the plasma levels of neurohormones change during NPWT. Six pigs underwent median sternotomy followed by NPWT at -125 mmHg. The plasma levels of noradrenaline, adrenaline, neuropeptide Y, substance P, vasoactive intestinal peptide (VIP), and calcitonin gene-related peptide (CGRP) were determined before (0 min) and 5, 20, 60 and 180 min after the application of NPWT. The results show a transient increase in the plasma levels of noradrenaline and adrenaline when NPWT was applied. The plasma level of the adrenergic co-transmitter neuropeptide Y was higher in NPWT - than in sham-treated pigs, after 180 min of negative pressure. After 180 min of NPWT there was an increase in the plasma levels of the sensory nerve transmitter substance P, while no such effect was observed for CGRP or VIP. In conclusion, the results suggest sympathetic nerve activation during NPWT. This may be the result of an increase in workload on the heart during the initial phase of NPWT. Keywords: Experimental surgery; Mediastinal infection; Wound healing; Noradrenaline; Adrenaline.},
  author       = {Torbrand, Christian and Wackenfors, Angelica and Lindstedt Ingemansson, Sandra and Ekman, Rolf and Ingemansson, Richard and Malmsjö, Malin},
  issn         = {1569-9285},
  keyword      = {mediastinal infection,experimental surgery,wound healing,noradrenaline,adrenaline},
  language     = {eng},
  number       = {6},
  pages        = {1067--1070},
  publisher    = {European Association of Cardio-Thoracic Surgery},
  series       = {Interactive Cardiovascular and Thoracic Surgery},
  title        = {Sympathetic and sensory nerve activation during negative pressure therapy of sternotomy wounds.},
  url          = {http://dx.doi.org/10.1510/icvts.2008.181792},
  volume       = {7},
  year         = {2008},
}