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Inflammation and immunity in diabetic vascular complications.

Nilsson, Jan LU ; Bengtsson, Eva LU orcid ; Nordin Fredrikson, Gunilla LU and Björkbacka, Harry LU orcid (2008) In Current Opinion in Lipidology 19(5). p.519-524
Abstract
PURPOSE OF REVIEW: Diabetes is associated with an increased risk for cardiovascular disease. The purpose of this review is to discuss possible mechanisms through which diabetes can contribute to a more aggressive atherosclerotic disease process with a particular focus on the role of innate and adaptive immunity. RECENT FINDINGS: The observation that adaptive immune responses to oxidized LDL modulate atherosclerotic plaque development has led to development of pilot vaccines that inhibit atherosclerosis in experimental animals. Recent studies have shown that similar immune responses operate against self-antigens modified by glycation in diabetes. Diabetes has also been shown to activate proinflammatory innate immune receptors and... (More)
PURPOSE OF REVIEW: Diabetes is associated with an increased risk for cardiovascular disease. The purpose of this review is to discuss possible mechanisms through which diabetes can contribute to a more aggressive atherosclerotic disease process with a particular focus on the role of innate and adaptive immunity. RECENT FINDINGS: The observation that adaptive immune responses to oxidized LDL modulate atherosclerotic plaque development has led to development of pilot vaccines that inhibit atherosclerosis in experimental animals. Recent studies have shown that similar immune responses operate against self-antigens modified by glycation in diabetes. Diabetes has also been shown to activate proinflammatory innate immune receptors and intracellular oxidative stress. SUMMARY: There are many similarities between the autoimmune responses against oxidized LDL and proteins modified by glycation. The role of autoimmune responses against modified self-antigens in the development of diabetic vascular complications represents a relatively unexplored concept that potentially could provide significant new mechanistic insight into the underlying disease process and identify novel targets for intervention. (Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Lipidology
volume
19
issue
5
pages
519 - 524
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000259349800012
  • pmid:18769234
  • scopus:53549101280
  • pmid:18769234
ISSN
1473-6535
DOI
10.1097/MOL.0b013e32830f47cd
language
English
LU publication?
yes
id
336a809b-87ef-44d2-89d0-151d7a19224c (old id 1243413)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18769234?dopt=Abstract
date added to LUP
2016-04-04 07:59:56
date last changed
2022-01-29 02:54:28
@article{336a809b-87ef-44d2-89d0-151d7a19224c,
  abstract     = {{PURPOSE OF REVIEW: Diabetes is associated with an increased risk for cardiovascular disease. The purpose of this review is to discuss possible mechanisms through which diabetes can contribute to a more aggressive atherosclerotic disease process with a particular focus on the role of innate and adaptive immunity. RECENT FINDINGS: The observation that adaptive immune responses to oxidized LDL modulate atherosclerotic plaque development has led to development of pilot vaccines that inhibit atherosclerosis in experimental animals. Recent studies have shown that similar immune responses operate against self-antigens modified by glycation in diabetes. Diabetes has also been shown to activate proinflammatory innate immune receptors and intracellular oxidative stress. SUMMARY: There are many similarities between the autoimmune responses against oxidized LDL and proteins modified by glycation. The role of autoimmune responses against modified self-antigens in the development of diabetic vascular complications represents a relatively unexplored concept that potentially could provide significant new mechanistic insight into the underlying disease process and identify novel targets for intervention.}},
  author       = {{Nilsson, Jan and Bengtsson, Eva and Nordin Fredrikson, Gunilla and Björkbacka, Harry}},
  issn         = {{1473-6535}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{519--524}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Current Opinion in Lipidology}},
  title        = {{Inflammation and immunity in diabetic vascular complications.}},
  url          = {{http://dx.doi.org/10.1097/MOL.0b013e32830f47cd}},
  doi          = {{10.1097/MOL.0b013e32830f47cd}},
  volume       = {{19}},
  year         = {{2008}},
}