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Abdominal aortic aneurysm and the impact of infectious burden

Nyberg, A.; Skagius, E.; Englund, E.; Nilsson, Ingrid LU ; Ljungh, Åsa LU and Henriksson, A. E. (2008) In European Journal of Vascular and Endovascular Surgery 36(3). p.292-296
Abstract
Objectives: Little is known about the biological processes causing aortic aneurysm rupture. Chronic Chlomydophila pneumoniae infection has been suggested as a possible contributing factor to the development and expansion of abdominal aortic aneurysm (AAA). The importance of infection in AAA may be related to the previous pathogen burden, that is, the number of significant titres of antibodies against infectious pathogens rather than to single infectious agents. The aim of this study was to examine the relationship between infectious burden and AAA rupture. Methods: In a case-control study, 119 patients with abdominal aortic aneurysm and 36 matched controls without aneurysm were prospectively investigated for specific. IgG class antibodies... (More)
Objectives: Little is known about the biological processes causing aortic aneurysm rupture. Chronic Chlomydophila pneumoniae infection has been suggested as a possible contributing factor to the development and expansion of abdominal aortic aneurysm (AAA). The importance of infection in AAA may be related to the previous pathogen burden, that is, the number of significant titres of antibodies against infectious pathogens rather than to single infectious agents. The aim of this study was to examine the relationship between infectious burden and AAA rupture. Methods: In a case-control study, 119 patients with abdominal aortic aneurysm and 36 matched controls without aneurysm were prospectively investigated for specific. IgG class antibodies against C. pneumoniae, Helicobacter pylori, Cytomegalovirus, and Herpes simplex virus. Results: Patients with ruptured AAA have similar levels of pathogen burden as patients with nonruptured electively operated AAA, small AAA, and controls without aneurysm. Conclusion: The present study fails to demonstrate a connection between infectious burden and abdominal aortic aneurysm rupture. (C) 2008 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
abdominal, aortic aneurysm, infectious burden, Chlamydophila pneumoniae, rupture
in
European Journal of Vascular and Endovascular Surgery
volume
36
issue
3
pages
292 - 296
publisher
Elsevier
external identifiers
  • wos:000259024900010
  • scopus:49349089752
ISSN
1532-2165
DOI
10.1016/j.ejvs.2008.04.017
language
English
LU publication?
yes
id
f0593b5f-05ee-4a75-962c-1d60fc9d1165 (old id 1246978)
date added to LUP
2008-11-17 11:06:34
date last changed
2017-07-09 04:08:48
@article{f0593b5f-05ee-4a75-962c-1d60fc9d1165,
  abstract     = {Objectives: Little is known about the biological processes causing aortic aneurysm rupture. Chronic Chlomydophila pneumoniae infection has been suggested as a possible contributing factor to the development and expansion of abdominal aortic aneurysm (AAA). The importance of infection in AAA may be related to the previous pathogen burden, that is, the number of significant titres of antibodies against infectious pathogens rather than to single infectious agents. The aim of this study was to examine the relationship between infectious burden and AAA rupture. Methods: In a case-control study, 119 patients with abdominal aortic aneurysm and 36 matched controls without aneurysm were prospectively investigated for specific. IgG class antibodies against C. pneumoniae, Helicobacter pylori, Cytomegalovirus, and Herpes simplex virus. Results: Patients with ruptured AAA have similar levels of pathogen burden as patients with nonruptured electively operated AAA, small AAA, and controls without aneurysm. Conclusion: The present study fails to demonstrate a connection between infectious burden and abdominal aortic aneurysm rupture. (C) 2008 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.},
  author       = {Nyberg, A. and Skagius, E. and Englund, E. and Nilsson, Ingrid and Ljungh, Åsa and Henriksson, A. E.},
  issn         = {1532-2165},
  keyword      = {abdominal,aortic aneurysm,infectious burden,Chlamydophila pneumoniae,rupture},
  language     = {eng},
  number       = {3},
  pages        = {292--296},
  publisher    = {Elsevier},
  series       = {European Journal of Vascular and Endovascular Surgery},
  title        = {Abdominal aortic aneurysm and the impact of infectious burden},
  url          = {http://dx.doi.org/10.1016/j.ejvs.2008.04.017},
  volume       = {36},
  year         = {2008},
}