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High plasma concentrations of autoantibodies against native peptide 210 of apoB-100 are related to less coronary atherosclerosis and lower risk of myocardial infarction

Sjogren, Per; Nordin Fredrikson, Gunilla LU ; Samnegard, Ann; Ericsson, Carl-Goran; Ohrvik, John; Fisher, Rachel M.; Nilsson, Jan LU and Hamsten, Anders (2008) In European Heart Journal 29(18). p.2218-2226
Abstract
Aims We examined whether antibodies against peptides 45 and 210 of apoB-100 are related to myocardial infarction (MI) and severity of coronary atherosclerosis. Methods and results Three hundred and eighty-seven survivors of a first MI (aged < 60 years) and 387 sex- and age-matched controls were characterized in detail. IgG and IgM autoantibodies against native and malondialdehyde (MDA)-modified peptides 45 and 210 of apoB-100 (amino acids 661-680 and 3136-3155) were quantified in plasma and quantitative coronary angiography was performed in 243 patients. Post-infarction patients had significantly lower IgG against the native peptide 210 (IgG-p210(nat)) and higher IgM against the MDA-modified peptide 210 (IgM-p210(MDA)) compared with... (More)
Aims We examined whether antibodies against peptides 45 and 210 of apoB-100 are related to myocardial infarction (MI) and severity of coronary atherosclerosis. Methods and results Three hundred and eighty-seven survivors of a first MI (aged < 60 years) and 387 sex- and age-matched controls were characterized in detail. IgG and IgM autoantibodies against native and malondialdehyde (MDA)-modified peptides 45 and 210 of apoB-100 (amino acids 661-680 and 3136-3155) were quantified in plasma and quantitative coronary angiography was performed in 243 patients. Post-infarction patients had significantly lower IgG against the native peptide 210 (IgG-p210(nat)) and higher IgM against the MDA-modified peptide 210 (IgM-p210(MDA)) compared with controls, whereas no differences were found for other antibodies. Plasma concentrations of IgG-p210(nat), but not IgM-p210(MDA), were independently and inversely related to the degree of coronary atherosclerosis in patients. In multiple logistic regression analysis (including established risk indicators), MI risk was 0.55 (95%CI: 0.37-0.81) for individuals in the IgG-p210(nat) upper quartile compared with the remaining individuals. Conclusion Circulating IgG antibodies against the native peptide 210 of apoB-100 are inversely related to the severity of coronary atherosclerosis and associated with lower risk of MI. Epitope 210 of apoB-100 emerges as a target for immunization against atherosclerosis in humans. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
coronary atherosclerosis, myocardial infarction, oxidized, angiography, LDL, autoantibodies, apoB-100
in
European Heart Journal
volume
29
issue
18
pages
2218 - 2226
publisher
Oxford University Press
external identifiers
  • wos:000259327000008
  • scopus:52449095211
ISSN
1522-9645
DOI
10.1093/eurheartj/ehn336
language
English
LU publication?
yes
id
24784ba5-6767-43a7-8052-6fb1177c03db (old id 1246986)
date added to LUP
2008-11-17 11:09:40
date last changed
2017-11-12 03:49:17
@article{24784ba5-6767-43a7-8052-6fb1177c03db,
  abstract     = {Aims We examined whether antibodies against peptides 45 and 210 of apoB-100 are related to myocardial infarction (MI) and severity of coronary atherosclerosis. Methods and results Three hundred and eighty-seven survivors of a first MI (aged &lt; 60 years) and 387 sex- and age-matched controls were characterized in detail. IgG and IgM autoantibodies against native and malondialdehyde (MDA)-modified peptides 45 and 210 of apoB-100 (amino acids 661-680 and 3136-3155) were quantified in plasma and quantitative coronary angiography was performed in 243 patients. Post-infarction patients had significantly lower IgG against the native peptide 210 (IgG-p210(nat)) and higher IgM against the MDA-modified peptide 210 (IgM-p210(MDA)) compared with controls, whereas no differences were found for other antibodies. Plasma concentrations of IgG-p210(nat), but not IgM-p210(MDA), were independently and inversely related to the degree of coronary atherosclerosis in patients. In multiple logistic regression analysis (including established risk indicators), MI risk was 0.55 (95%CI: 0.37-0.81) for individuals in the IgG-p210(nat) upper quartile compared with the remaining individuals. Conclusion Circulating IgG antibodies against the native peptide 210 of apoB-100 are inversely related to the severity of coronary atherosclerosis and associated with lower risk of MI. Epitope 210 of apoB-100 emerges as a target for immunization against atherosclerosis in humans.},
  author       = {Sjogren, Per and Nordin Fredrikson, Gunilla and Samnegard, Ann and Ericsson, Carl-Goran and Ohrvik, John and Fisher, Rachel M. and Nilsson, Jan and Hamsten, Anders},
  issn         = {1522-9645},
  keyword      = {coronary atherosclerosis,myocardial infarction,oxidized,angiography,LDL,autoantibodies,apoB-100},
  language     = {eng},
  number       = {18},
  pages        = {2218--2226},
  publisher    = {Oxford University Press},
  series       = {European Heart Journal},
  title        = {High plasma concentrations of autoantibodies against native peptide 210 of apoB-100 are related to less coronary atherosclerosis and lower risk of myocardial infarction},
  url          = {http://dx.doi.org/10.1093/eurheartj/ehn336},
  volume       = {29},
  year         = {2008},
}