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Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis

Lutgens, E.; Tjwa, M.; Garcia de Frutos, P LU ; Wijnands, E.; Beckers, L.; Dahlbäck, B LU ; Daemen, M. J. A. P.; Carmeliet, P. and Moons, L. (2008) In Journal of Pathology 216(1). p.55-63
Abstract

The growth arrest-specific gene 6 (Gas6) plays a role in pro-atherogenic processes such as endothelial and leukocyte activation, smooth muscle cell migration and thrombosis, but its role in atherosclerosis remains uninvestigated. Here, we report that Gas6 is expressed in all stages of human and mouse atherosclerosis, in plaque endothelial cells, smooth muscle cells and macrophages. Gas6 expression is most abundant in lesions containing high amounts of macrophages, ie thin fibrous cap atheroma and ruptured plaque. Genetic loss of Gas6 does not affect the number and size of initial and advanced plaques in ApoE(-/-) mice, but alters its plaque composition. Compared to Gas6(+/+): ApoE(-/-) mice, initial and advanced plaques of Gas6(-/-):... (More)

The growth arrest-specific gene 6 (Gas6) plays a role in pro-atherogenic processes such as endothelial and leukocyte activation, smooth muscle cell migration and thrombosis, but its role in atherosclerosis remains uninvestigated. Here, we report that Gas6 is expressed in all stages of human and mouse atherosclerosis, in plaque endothelial cells, smooth muscle cells and macrophages. Gas6 expression is most abundant in lesions containing high amounts of macrophages, ie thin fibrous cap atheroma and ruptured plaque. Genetic loss of Gas6 does not affect the number and size of initial and advanced plaques in ApoE(-/-) mice, but alters its plaque composition. Compared to Gas6(+/+): ApoE(-/-) mice, initial and advanced plaques of Gas6(-/-): ApoE(-/-) mice contained more smooth muscle cells and more collagen and developed smaller lipid cores, while the expression of TGFbeta was increased. In addition, fewer macrophages were found in advanced plaques of Gas6(-/-): ApoE(-/-) mice. Hence, loss of Gas6 promotes the formation of more stable atherosclerotic lesions by increasing plaque fibrosis and by attenuating plaque inflammation. These findings identify a role for Gas6 in plaque composition and stability.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
fibrosis, stability, plaque, plaque composition, TGF beta, atherosclerosis, Gas6, ApoE
in
Journal of Pathology
volume
216
issue
1
pages
9 pages
publisher
John Wiley & Sons
external identifiers
  • wos:000258969000006
  • scopus:50249097337
ISSN
0022-3417
DOI
10.1002/path.2381
language
English
LU publication?
yes
id
3461a9bc-45ec-4883-bc3b-6bcdece482f7 (old id 1247235)
date added to LUP
2008-11-19 16:26:23
date last changed
2017-06-20 10:31:19
@article{3461a9bc-45ec-4883-bc3b-6bcdece482f7,
  abstract     = {<p>The growth arrest-specific gene 6 (Gas6) plays a role in pro-atherogenic processes such as endothelial and leukocyte activation, smooth muscle cell migration and thrombosis, but its role in atherosclerosis remains uninvestigated. Here, we report that Gas6 is expressed in all stages of human and mouse atherosclerosis, in plaque endothelial cells, smooth muscle cells and macrophages. Gas6 expression is most abundant in lesions containing high amounts of macrophages, ie thin fibrous cap atheroma and ruptured plaque. Genetic loss of Gas6 does not affect the number and size of initial and advanced plaques in ApoE(-/-) mice, but alters its plaque composition. Compared to Gas6(+/+): ApoE(-/-) mice, initial and advanced plaques of Gas6(-/-): ApoE(-/-) mice contained more smooth muscle cells and more collagen and developed smaller lipid cores, while the expression of TGFbeta was increased. In addition, fewer macrophages were found in advanced plaques of Gas6(-/-): ApoE(-/-) mice. Hence, loss of Gas6 promotes the formation of more stable atherosclerotic lesions by increasing plaque fibrosis and by attenuating plaque inflammation. These findings identify a role for Gas6 in plaque composition and stability.</p>},
  author       = {Lutgens, E. and Tjwa, M. and Garcia de Frutos, P and Wijnands, E. and Beckers, L. and Dahlbäck, B and Daemen, M. J. A. P. and Carmeliet, P. and Moons, L.},
  issn         = {0022-3417},
  keyword      = {fibrosis,stability,plaque,plaque composition,TGF beta,atherosclerosis,Gas6,ApoE},
  language     = {eng},
  number       = {1},
  pages        = {55--63},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Pathology},
  title        = {Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis},
  url          = {http://dx.doi.org/10.1002/path.2381},
  volume       = {216},
  year         = {2008},
}