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Ptychographic reconstructions performed in real time and offline have equivalent quality

Lexelius, Rebecka LU ; Kahnt, Maik LU orcid and Maia, Filipe R.N.C. (2025) In Scientific Reports 15(1).
Abstract

Ptychography is a burgeoning imaging technique that enables high-resolution, lensless reconstruction of complex samples by analysing overlapping diffraction patterns, making it invaluable in fields like materials science, biology, and nanotechnology. Real-time ptychographic reconstructions are gaining interest in the scientific community as they provide immediate feedback. Yet their potential to replace offline reconstructions remains uncertain, in part due to questions about the quality of the resulting images. This study quantitatively compares real-time and offline reconstructions at different overlap conditions. Offline reconstructions, using all diffraction patterns at once, and real-time reconstructions, where new frames are added... (More)

Ptychography is a burgeoning imaging technique that enables high-resolution, lensless reconstruction of complex samples by analysing overlapping diffraction patterns, making it invaluable in fields like materials science, biology, and nanotechnology. Real-time ptychographic reconstructions are gaining interest in the scientific community as they provide immediate feedback. Yet their potential to replace offline reconstructions remains uncertain, in part due to questions about the quality of the resulting images. This study quantitatively compares real-time and offline reconstructions at different overlap conditions. Offline reconstructions, using all diffraction patterns at once, and real-time reconstructions, where new frames are added to the reconstructions in small chunks as the diffraction patterns are recorded, were indistinguishable and identical in reconstruction quality. These results hold consistently across all tested overlap ratios. This study represents the first quantitative analysis of real-time ptychographic reconstruction using a growing dataset, demonstrating the potential for real-time reconstructions to replace or at least complement offline reconstructions.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
15
issue
1
article number
14674
publisher
Nature Publishing Group
external identifiers
  • pmid:40287546
  • scopus:105003703817
ISSN
2045-2322
DOI
10.1038/s41598-025-99740-z
language
English
LU publication?
yes
additional info
Publisher Copyright: © The Author(s) 2025.
id
12501268-a730-4f03-80b6-63aeee8aa5a1
date added to LUP
2025-05-19 13:52:20
date last changed
2025-07-14 17:55:22
@article{12501268-a730-4f03-80b6-63aeee8aa5a1,
  abstract     = {{<p>Ptychography is a burgeoning imaging technique that enables high-resolution, lensless reconstruction of complex samples by analysing overlapping diffraction patterns, making it invaluable in fields like materials science, biology, and nanotechnology. Real-time ptychographic reconstructions are gaining interest in the scientific community as they provide immediate feedback. Yet their potential to replace offline reconstructions remains uncertain, in part due to questions about the quality of the resulting images. This study quantitatively compares real-time and offline reconstructions at different overlap conditions. Offline reconstructions, using all diffraction patterns at once, and real-time reconstructions, where new frames are added to the reconstructions in small chunks as the diffraction patterns are recorded, were indistinguishable and identical in reconstruction quality. These results hold consistently across all tested overlap ratios. This study represents the first quantitative analysis of real-time ptychographic reconstruction using a growing dataset, demonstrating the potential for real-time reconstructions to replace or at least complement offline reconstructions.</p>}},
  author       = {{Lexelius, Rebecka and Kahnt, Maik and Maia, Filipe R.N.C.}},
  issn         = {{2045-2322}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Ptychographic reconstructions performed in real time and offline have equivalent quality}},
  url          = {{http://dx.doi.org/10.1038/s41598-025-99740-z}},
  doi          = {{10.1038/s41598-025-99740-z}},
  volume       = {{15}},
  year         = {{2025}},
}