Panel 4: Recent Advances in Otitis Media in Molecular Biology, Biochemistry, Genetics, and Animal Models
(2013) In Otolaryngology: Head and Neck Surgery 148. p.52-63- Abstract
- Background. Otitis media (OM) is the most common childhood bacterial infection and also the leading cause of conductive hearing loss in children. Currently, there is an urgent need for developing novel therapeutic agents for treating OM based on full understanding of molecular pathogenesis in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM. Objective. To provide a state-of-the-art review concerning recent advances in OM in the areas of molecular biology, biochemistry, genetics, and animal model studies and to discuss the future directions of OM studies in these areas. Data Sources and Review Methods. A structured search of the current literature (since June 2007). The authors searched PubMed for... (More)
- Background. Otitis media (OM) is the most common childhood bacterial infection and also the leading cause of conductive hearing loss in children. Currently, there is an urgent need for developing novel therapeutic agents for treating OM based on full understanding of molecular pathogenesis in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM. Objective. To provide a state-of-the-art review concerning recent advances in OM in the areas of molecular biology, biochemistry, genetics, and animal model studies and to discuss the future directions of OM studies in these areas. Data Sources and Review Methods. A structured search of the current literature (since June 2007). The authors searched PubMed for published literature in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM. Results. Over the past 4 years, significant progress has been made in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM. These studies brought new insights into our understanding of the molecular and biochemical mechanisms underlying the molecular pathogenesis of OM and helped identify novel therapeutic targets for OM. Conclusions and Implications for Practice. Our understanding of the molecular pathogenesis of OM has been significantly advanced, particularly in the areas of inflammation, innate immunity, mucus overproduction, mucosal hyperplasia, middle ear and inner ear interaction, genetics, genome sequencing, and animal model studies. Although these studies are still in their experimental stages, they help identify new potential therapeutic targets. Future preclinical and clinical studies will help to translate these exciting experimental research findings into clinical applications. (Less)
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https://lup.lub.lu.se/record/3821830
- author
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- otitis media, molecular biology, biochemistry, inflammation, cytokine, chemokine, innate immunity, cell signaling, tissue remodeling
- in
- Otolaryngology: Head and Neck Surgery
- volume
- 148
- pages
- 52 - 63
- publisher
- Mosby-Elsevier
- external identifiers
-
- wos:000318365300004
- scopus:84878853993
- pmid:23536532
- ISSN
- 0194-5998
- DOI
- 10.1177/0194599813479772
- language
- English
- LU publication?
- yes
- id
- 12513275-c7e8-4dca-99ea-4aad83b5e8b0 (old id 3821830)
- date added to LUP
- 2016-04-01 14:36:47
- date last changed
- 2022-03-06 20:13:36
@article{12513275-c7e8-4dca-99ea-4aad83b5e8b0,
abstract = {{Background. Otitis media (OM) is the most common childhood bacterial infection and also the leading cause of conductive hearing loss in children. Currently, there is an urgent need for developing novel therapeutic agents for treating OM based on full understanding of molecular pathogenesis in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM. Objective. To provide a state-of-the-art review concerning recent advances in OM in the areas of molecular biology, biochemistry, genetics, and animal model studies and to discuss the future directions of OM studies in these areas. Data Sources and Review Methods. A structured search of the current literature (since June 2007). The authors searched PubMed for published literature in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM. Results. Over the past 4 years, significant progress has been made in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM. These studies brought new insights into our understanding of the molecular and biochemical mechanisms underlying the molecular pathogenesis of OM and helped identify novel therapeutic targets for OM. Conclusions and Implications for Practice. Our understanding of the molecular pathogenesis of OM has been significantly advanced, particularly in the areas of inflammation, innate immunity, mucus overproduction, mucosal hyperplasia, middle ear and inner ear interaction, genetics, genome sequencing, and animal model studies. Although these studies are still in their experimental stages, they help identify new potential therapeutic targets. Future preclinical and clinical studies will help to translate these exciting experimental research findings into clinical applications.}},
author = {{Li, Jian-Dong and Hermansson, Ann and Ryan, Allen F. and Bakaletz, Lauren O. and Brown, Steve D. and Cheeseman, Michael T. and Juhn, Steven K. and Jung, Timothy T. K. and Lim, David J. and Lim, Jae Hyang and Lin, Jizhen and Moon, Sung-Kyun and Post, J. Christopher}},
issn = {{0194-5998}},
keywords = {{otitis media; molecular biology; biochemistry; inflammation; cytokine; chemokine; innate immunity; cell signaling; tissue remodeling}},
language = {{eng}},
pages = {{52--63}},
publisher = {{Mosby-Elsevier}},
series = {{Otolaryngology: Head and Neck Surgery}},
title = {{Panel 4: Recent Advances in Otitis Media in Molecular Biology, Biochemistry, Genetics, and Animal Models}},
url = {{http://dx.doi.org/10.1177/0194599813479772}},
doi = {{10.1177/0194599813479772}},
volume = {{148}},
year = {{2013}},
}