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How should women with pre-eclampsia be followed up? New insights from mechanistic studies

Hertig, Alexandre; Watnick, Suzanne; Strevens, Helena LU ; Boulanger, Henri; Berkane, Nadia and Rondeau, Eric (2008) In Nature Clinical Practice Nephrology 4(9). p.503-509
Abstract
Understanding of the maternal syndrome of pre-eclampsia has greatly improved over the past 5 years. Specifically, the notion has emerged that the placenta is a source of antiangiogenic factors, such as soluble fms-like tyrosine kinase 1, that can progressively impair the mother's vascular and glomerular function throughout pregnancy. This impairment can be harmless during normal pregnancy, but in cases of defective placentation, concentrations of antiangiogenic factors increase to a level that compromises vital vascular functions in the short term and jeopardizes long-term maternal and fetal outcomes. In both pre-eclamptic and healthy pregnancies, the transient imbalance between angiogenic and antiangiogenic factors elicited by pregnancy... (More)
Understanding of the maternal syndrome of pre-eclampsia has greatly improved over the past 5 years. Specifically, the notion has emerged that the placenta is a source of antiangiogenic factors, such as soluble fms-like tyrosine kinase 1, that can progressively impair the mother's vascular and glomerular function throughout pregnancy. This impairment can be harmless during normal pregnancy, but in cases of defective placentation, concentrations of antiangiogenic factors increase to a level that compromises vital vascular functions in the short term and jeopardizes long-term maternal and fetal outcomes. In both pre-eclamptic and healthy pregnancies, the transient imbalance between angiogenic and antiangiogenic factors elicited by pregnancy acts as a 'stress test' for the endothelium, particularly in the glomerular capillary bed. Women who do not pass this test (i.e. those who develop pre-eclampsia or gestational hypertension) should be screened for glomerular disease, and their cardiovascular risk should be carefully monitored throughout life. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pre-eclampsia, gestational hypertension, glomerular endotheliosis, pregnancy, sFlt-1
in
Nature Clinical Practice Nephrology
volume
4
issue
9
pages
503 - 509
publisher
Nature Publishing Group
external identifiers
  • wos:000258573700013
  • scopus:50249147366
ISSN
1745-8323
DOI
10.1038/ncpneph0880
language
English
LU publication?
yes
id
44b14b99-11a8-4297-b110-aaa86097935a (old id 1251843)
date added to LUP
2008-11-05 11:07:56
date last changed
2017-01-01 06:09:54
@article{44b14b99-11a8-4297-b110-aaa86097935a,
  abstract     = {Understanding of the maternal syndrome of pre-eclampsia has greatly improved over the past 5 years. Specifically, the notion has emerged that the placenta is a source of antiangiogenic factors, such as soluble fms-like tyrosine kinase 1, that can progressively impair the mother's vascular and glomerular function throughout pregnancy. This impairment can be harmless during normal pregnancy, but in cases of defective placentation, concentrations of antiangiogenic factors increase to a level that compromises vital vascular functions in the short term and jeopardizes long-term maternal and fetal outcomes. In both pre-eclamptic and healthy pregnancies, the transient imbalance between angiogenic and antiangiogenic factors elicited by pregnancy acts as a 'stress test' for the endothelium, particularly in the glomerular capillary bed. Women who do not pass this test (i.e. those who develop pre-eclampsia or gestational hypertension) should be screened for glomerular disease, and their cardiovascular risk should be carefully monitored throughout life.},
  author       = {Hertig, Alexandre and Watnick, Suzanne and Strevens, Helena and Boulanger, Henri and Berkane, Nadia and Rondeau, Eric},
  issn         = {1745-8323},
  keyword      = {pre-eclampsia,gestational hypertension,glomerular endotheliosis,pregnancy,sFlt-1},
  language     = {eng},
  number       = {9},
  pages        = {503--509},
  publisher    = {Nature Publishing Group},
  series       = {Nature Clinical Practice Nephrology},
  title        = {How should women with pre-eclampsia be followed up? New insights from mechanistic studies},
  url          = {http://dx.doi.org/10.1038/ncpneph0880},
  volume       = {4},
  year         = {2008},
}