How should women with pre-eclampsia be followed up? New insights from mechanistic studies
(2008) In Nature Clinical Practice Nephrology 4(9). p.503-509- Abstract
- Understanding of the maternal syndrome of pre-eclampsia has greatly improved over the past 5 years. Specifically, the notion has emerged that the placenta is a source of antiangiogenic factors, such as soluble fms-like tyrosine kinase 1, that can progressively impair the mother's vascular and glomerular function throughout pregnancy. This impairment can be harmless during normal pregnancy, but in cases of defective placentation, concentrations of antiangiogenic factors increase to a level that compromises vital vascular functions in the short term and jeopardizes long-term maternal and fetal outcomes. In both pre-eclamptic and healthy pregnancies, the transient imbalance between angiogenic and antiangiogenic factors elicited by pregnancy... (More)
- Understanding of the maternal syndrome of pre-eclampsia has greatly improved over the past 5 years. Specifically, the notion has emerged that the placenta is a source of antiangiogenic factors, such as soluble fms-like tyrosine kinase 1, that can progressively impair the mother's vascular and glomerular function throughout pregnancy. This impairment can be harmless during normal pregnancy, but in cases of defective placentation, concentrations of antiangiogenic factors increase to a level that compromises vital vascular functions in the short term and jeopardizes long-term maternal and fetal outcomes. In both pre-eclamptic and healthy pregnancies, the transient imbalance between angiogenic and antiangiogenic factors elicited by pregnancy acts as a 'stress test' for the endothelium, particularly in the glomerular capillary bed. Women who do not pass this test (i.e. those who develop pre-eclampsia or gestational hypertension) should be screened for glomerular disease, and their cardiovascular risk should be carefully monitored throughout life. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1251843
- author
- Hertig, Alexandre ; Watnick, Suzanne ; Strevens, Helena LU ; Boulanger, Henri ; Berkane, Nadia and Rondeau, Eric
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- pre-eclampsia, gestational hypertension, glomerular endotheliosis, pregnancy, sFlt-1
- in
- Nature Clinical Practice Nephrology
- volume
- 4
- issue
- 9
- pages
- 503 - 509
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000258573700013
- scopus:50249147366
- pmid:18628742
- ISSN
- 1745-8323
- DOI
- 10.1038/ncpneph0880
- language
- English
- LU publication?
- yes
- id
- 44b14b99-11a8-4297-b110-aaa86097935a (old id 1251843)
- date added to LUP
- 2016-04-01 14:17:32
- date last changed
- 2022-01-27 23:50:59
@article{44b14b99-11a8-4297-b110-aaa86097935a,
abstract = {{Understanding of the maternal syndrome of pre-eclampsia has greatly improved over the past 5 years. Specifically, the notion has emerged that the placenta is a source of antiangiogenic factors, such as soluble fms-like tyrosine kinase 1, that can progressively impair the mother's vascular and glomerular function throughout pregnancy. This impairment can be harmless during normal pregnancy, but in cases of defective placentation, concentrations of antiangiogenic factors increase to a level that compromises vital vascular functions in the short term and jeopardizes long-term maternal and fetal outcomes. In both pre-eclamptic and healthy pregnancies, the transient imbalance between angiogenic and antiangiogenic factors elicited by pregnancy acts as a 'stress test' for the endothelium, particularly in the glomerular capillary bed. Women who do not pass this test (i.e. those who develop pre-eclampsia or gestational hypertension) should be screened for glomerular disease, and their cardiovascular risk should be carefully monitored throughout life.}},
author = {{Hertig, Alexandre and Watnick, Suzanne and Strevens, Helena and Boulanger, Henri and Berkane, Nadia and Rondeau, Eric}},
issn = {{1745-8323}},
keywords = {{pre-eclampsia; gestational hypertension; glomerular endotheliosis; pregnancy; sFlt-1}},
language = {{eng}},
number = {{9}},
pages = {{503--509}},
publisher = {{Nature Publishing Group}},
series = {{Nature Clinical Practice Nephrology}},
title = {{How should women with pre-eclampsia be followed up? New insights from mechanistic studies}},
url = {{http://dx.doi.org/10.1038/ncpneph0880}},
doi = {{10.1038/ncpneph0880}},
volume = {{4}},
year = {{2008}},
}