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Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies

Ahnström, Josefin LU ; Axler, Olof LU ; Jauhiainen, Matti; Salomaa, Veikko; Havulinna, Aki S.; Ehnholm, Christian; Frikke-Schmidt, Ruth; Tybjaerg-Hansen, Anne and Dahlbäck, Björn LU (2008) In Journal of Lipid Research 49(9). p.1912-1917
Abstract
Apolipoprotein M (apoM), a 25 kDa plasma protein belonging to the lipocalin protein family, is predominantly associated with HDL. Studies in mice have suggested apoM to be important for the formation of pre-beta-HDL and to increase cholesterol efflux from macrophage foam cells. Overexpression of human apoM in LDL receptor-deficient mice reduced the atherogenic effect of a cholesterol-rich diet. The aim of the present study was to investigate whether the apoM levels in man predict the risk for coronary heart disease (CHD). ApoM was measured in samples from two separate case-control studies. FINRISK '92 consisted of 255 individuals, of whom 80 developed CHD during follow-up and 175 were controls. The Copenhagen City Heart Study included... (More)
Apolipoprotein M (apoM), a 25 kDa plasma protein belonging to the lipocalin protein family, is predominantly associated with HDL. Studies in mice have suggested apoM to be important for the formation of pre-beta-HDL and to increase cholesterol efflux from macrophage foam cells. Overexpression of human apoM in LDL receptor-deficient mice reduced the atherogenic effect of a cholesterol-rich diet. The aim of the present study was to investigate whether the apoM levels in man predict the risk for coronary heart disease (CHD). ApoM was measured in samples from two separate case-control studies. FINRISK '92 consisted of 255 individuals, of whom 80 developed CHD during follow-up and 175 were controls. The Copenhagen City Heart Study included 1,865 individuals, of whom 921 developed CHD during follow-up and 944 were controls. Correlation studies of apoM concentration with several analytes showed a marked positive correlation with HDL and total cholesterol as well as with apoA-I and apoB. There was no significant difference in mean apoM level between CHD and control subjects in either study. In conditional logistic regression analyses, apoM was not a predictor of CHD events, [odds ratio (95% CI) 0.97 (0.74-1.27) and 0.92 (0.84-1.02), respectively]. In conclusion, no association between apoM and CHD could be found in this study.-Ahnstrom, J., O. Axler, M. Jauhiainen, V. Salomaa, A. S. Havulinna, C. Ehnholm, R. Frikke-Schmidt, A. Tybjaerg-Hansen, and B. Dahlback. Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
signal peptide, cholesterol, lipocalin, FINRISK, Copenhagen City Heart, Study
in
Journal of Lipid Research
volume
49
issue
9
pages
1912 - 1917
publisher
American Society for Biochemistry and Molecular Biology
external identifiers
  • wos:000258472500006
  • scopus:53149121326
ISSN
1539-7262
DOI
10.1194/jlr.M700471-JLR200
language
English
LU publication?
yes
id
bc1c4719-699a-439d-9eb5-05cb36ed9110 (old id 1251862)
date added to LUP
2008-11-04 14:34:21
date last changed
2017-09-24 03:36:55
@article{bc1c4719-699a-439d-9eb5-05cb36ed9110,
  abstract     = {Apolipoprotein M (apoM), a 25 kDa plasma protein belonging to the lipocalin protein family, is predominantly associated with HDL. Studies in mice have suggested apoM to be important for the formation of pre-beta-HDL and to increase cholesterol efflux from macrophage foam cells. Overexpression of human apoM in LDL receptor-deficient mice reduced the atherogenic effect of a cholesterol-rich diet. The aim of the present study was to investigate whether the apoM levels in man predict the risk for coronary heart disease (CHD). ApoM was measured in samples from two separate case-control studies. FINRISK '92 consisted of 255 individuals, of whom 80 developed CHD during follow-up and 175 were controls. The Copenhagen City Heart Study included 1,865 individuals, of whom 921 developed CHD during follow-up and 944 were controls. Correlation studies of apoM concentration with several analytes showed a marked positive correlation with HDL and total cholesterol as well as with apoA-I and apoB. There was no significant difference in mean apoM level between CHD and control subjects in either study. In conditional logistic regression analyses, apoM was not a predictor of CHD events, [odds ratio (95% CI) 0.97 (0.74-1.27) and 0.92 (0.84-1.02), respectively]. In conclusion, no association between apoM and CHD could be found in this study.-Ahnstrom, J., O. Axler, M. Jauhiainen, V. Salomaa, A. S. Havulinna, C. Ehnholm, R. Frikke-Schmidt, A. Tybjaerg-Hansen, and B. Dahlback. Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies.},
  author       = {Ahnström, Josefin and Axler, Olof and Jauhiainen, Matti and Salomaa, Veikko and Havulinna, Aki S. and Ehnholm, Christian and Frikke-Schmidt, Ruth and Tybjaerg-Hansen, Anne and Dahlbäck, Björn},
  issn         = {1539-7262},
  keyword      = {signal peptide,cholesterol,lipocalin,FINRISK,Copenhagen City Heart,Study},
  language     = {eng},
  number       = {9},
  pages        = {1912--1917},
  publisher    = {American Society for Biochemistry and Molecular Biology},
  series       = {Journal of Lipid Research},
  title        = {Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies},
  url          = {http://dx.doi.org/10.1194/jlr.M700471-JLR200},
  volume       = {49},
  year         = {2008},
}