Advanced

Late cardiovascular events after allogeneic hematopoietic stem cell transplantation: a retrospective multicenter study of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation

Tichelli, Andre; Passweg, Jakob; Wojcik, Dorota; Rovo, Alicia; Harousseau, Jean-Luc; Masszi, Tamas; Zander, Axel; Békássy, Albert LU ; Crawley, Charles and Arat, Mutlu, et al. (2008) In Haematologica 93(8). p.1203-1210
Abstract
Background Long-term outcome after hematopoietic stem cell transplantation including late transplant-related events is of increasing interest. The aim of this study was to evaluate the incidence of cardiovascular events after allogeneic HSCT and to search for their risk factors. Design and Methods This is a retrospective mutlicenter European Group of Blood and Marrow Transplantation (EBMT) analysis, including 548 long-term survivors treated in ten EBMT transplant centers, who underwent hematopoietic stem cell transplantation between 1990 and 1995 and survived >= 1 year after the transplant. All arterial events occurring after hematopoietic stem cell transplantation (cerebral, coronary, peripheral) were reported. Results Twenty (3.6%)... (More)
Background Long-term outcome after hematopoietic stem cell transplantation including late transplant-related events is of increasing interest. The aim of this study was to evaluate the incidence of cardiovascular events after allogeneic HSCT and to search for their risk factors. Design and Methods This is a retrospective mutlicenter European Group of Blood and Marrow Transplantation (EBMT) analysis, including 548 long-term survivors treated in ten EBMT transplant centers, who underwent hematopoietic stem cell transplantation between 1990 and 1995 and survived >= 1 year after the transplant. All arterial events occurring after hematopoietic stem cell transplantation (cerebral, coronary, peripheral) were reported. Results Twenty (3.6%) out of 548 patients had a cardiovascular event in at least one arterial territory. The median age at occurence of cardiovascular events was 54 years (range, 41-70). The cumulative incidence of a first arterial event 15 years after hematopoietic stem cell transplantation was 6% (95% CI, 3%-10%). The cumulative incidence for patients with a high global cardiovascular risk score, defined as having >= 50% of the risk factors (arterial hypertension, diabetes, dyslipidemia, increased body-mass index, physical inactivity, smoking) was 17%, as compared to 4% in those with a low risk score. In multivariate analysis age older than 30 years at last follow-up, and a high global cardiovascular risk score were associated with, respectively, 6.4-fold and 9.8-fold increases in the risk of an arterial event. Conclusions Long-term survivors after allogeneic hematopoietic stem cell transplantation are likely to have an increased risk of premature cardiovascular accidents. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
late effects, stem cell transplantation, cardiovascular, long-term, survivors
in
Haematologica
volume
93
issue
8
pages
1203 - 1210
publisher
Ferrata Storti Foundation
external identifiers
  • wos:000257954300013
  • scopus:48749091809
ISSN
1592-8721
DOI
10.3324/haematol.12949
language
English
LU publication?
yes
id
d2380063-e63f-4d9b-b414-0e0fbdf5b372 (old id 1253685)
date added to LUP
2008-11-07 14:55:46
date last changed
2017-10-01 04:01:21
@article{d2380063-e63f-4d9b-b414-0e0fbdf5b372,
  abstract     = {Background Long-term outcome after hematopoietic stem cell transplantation including late transplant-related events is of increasing interest. The aim of this study was to evaluate the incidence of cardiovascular events after allogeneic HSCT and to search for their risk factors. Design and Methods This is a retrospective mutlicenter European Group of Blood and Marrow Transplantation (EBMT) analysis, including 548 long-term survivors treated in ten EBMT transplant centers, who underwent hematopoietic stem cell transplantation between 1990 and 1995 and survived >= 1 year after the transplant. All arterial events occurring after hematopoietic stem cell transplantation (cerebral, coronary, peripheral) were reported. Results Twenty (3.6%) out of 548 patients had a cardiovascular event in at least one arterial territory. The median age at occurence of cardiovascular events was 54 years (range, 41-70). The cumulative incidence of a first arterial event 15 years after hematopoietic stem cell transplantation was 6% (95% CI, 3%-10%). The cumulative incidence for patients with a high global cardiovascular risk score, defined as having >= 50% of the risk factors (arterial hypertension, diabetes, dyslipidemia, increased body-mass index, physical inactivity, smoking) was 17%, as compared to 4% in those with a low risk score. In multivariate analysis age older than 30 years at last follow-up, and a high global cardiovascular risk score were associated with, respectively, 6.4-fold and 9.8-fold increases in the risk of an arterial event. Conclusions Long-term survivors after allogeneic hematopoietic stem cell transplantation are likely to have an increased risk of premature cardiovascular accidents.},
  author       = {Tichelli, Andre and Passweg, Jakob and Wojcik, Dorota and Rovo, Alicia and Harousseau, Jean-Luc and Masszi, Tamas and Zander, Axel and Békássy, Albert and Crawley, Charles and Arat, Mutlu and Sica, Simona and Lutz, Patrick and Socie, Gerard},
  issn         = {1592-8721},
  keyword      = {late effects,stem cell transplantation,cardiovascular,long-term,survivors},
  language     = {eng},
  number       = {8},
  pages        = {1203--1210},
  publisher    = {Ferrata Storti Foundation},
  series       = {Haematologica},
  title        = {Late cardiovascular events after allogeneic hematopoietic stem cell transplantation: a retrospective multicenter study of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation},
  url          = {http://dx.doi.org/10.3324/haematol.12949},
  volume       = {93},
  year         = {2008},
}