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Adipose tissue fatty acid metabolism in insulin-resistant men

Bickerton, A. S. T.; Roberts, R.; Fielding, B. A.; Tornqvist, Hans LU ; Blaak, E. E.; Wagenmakers, A. J. M.; Gilbert, M.; Humphreys, Keith LU ; Karpe, F. and Frayn, K. N. (2008) In Diabetologia 51(8). p.1466-1474
Abstract
Aims/hypothesis Increased NEFA production and concentrations may underlie insulin resistance. We examined systemic and adipose tissue NEFA metabolism in insulin-resistant overweight men (BM1 25-35 kg/m(2)). Methods In a cohort study we examined NEFA concentrations in men in the upper quartile of fasting insulin (n = 124) and in men with fasting insulin below the median (n 159). In a metabolic study we examined NEFA metabolism in the fasting and postprandial states, in ten insulin-resistant men and ten controls. Results In the cohort study, fasting NEFA concentrations were not significantly different between the two groups (median values: insulin-resistant men, 410 mu mol/l; controls, 445 2 mu mol/l). However, triacylglycerol concentrations... (More)
Aims/hypothesis Increased NEFA production and concentrations may underlie insulin resistance. We examined systemic and adipose tissue NEFA metabolism in insulin-resistant overweight men (BM1 25-35 kg/m(2)). Methods In a cohort study we examined NEFA concentrations in men in the upper quartile of fasting insulin (n = 124) and in men with fasting insulin below the median (n 159). In a metabolic study we examined NEFA metabolism in the fasting and postprandial states, in ten insulin-resistant men and ten controls. Results In the cohort study, fasting NEFA concentrations were not significantly different between the two groups (median values: insulin-resistant men, 410 mu mol/l; controls, 445 2 mu mol/l). However, triacylglycerol concentrations differed markedly (1.84 vs 1.18 mmol/l respectively, p<0.001). In the metabolic study, arterial NEFA concentrations again did not differ between groups, whereas triacylglycerol concentrations were significantly higher in insulin-resistant men. Systemic NEFA production and the release of NEFA from subcutaneous adipose tissue, expressed per unit of fat mass, were both reduced in insulin-resistant men compared with controls (fasting values by 32%, p=0.02, and 44%, p=0.04 respectively). 3-Hydroxybutyrate concentrations, an index of hepatic fat oxidation and ketogenesis, were lower (p=0.03). Conclusions/interpretation Adipose tissue NEFA output is not increased (per unit weight of tissue) in insulin resistance. On the contrary, it appears to be suppressed by high fasting insulin concentrations. Alterations in triacylglycerol metabolism are more marked than those in NEFA metabolism. and are indicative of altered metabolic partitioning of fatty acids (decreased oxidation, increased esterification) in the liver. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
non-esterified fatty acids, adipose tissue, insulin resistance, triacylglycerol
in
Diabetologia
volume
51
issue
8
pages
1466 - 1474
publisher
Springer Verlag
external identifiers
  • wos:000257848900017
  • scopus:48149097201
ISSN
1432-0428
DOI
10.1007/s00125-008-1040-x
language
English
LU publication?
yes
id
a708969f-9bad-4c2b-aa91-e4f9bbf18b69 (old id 1253757)
date added to LUP
2008-11-07 14:43:27
date last changed
2017-10-08 03:29:13
@article{a708969f-9bad-4c2b-aa91-e4f9bbf18b69,
  abstract     = {Aims/hypothesis Increased NEFA production and concentrations may underlie insulin resistance. We examined systemic and adipose tissue NEFA metabolism in insulin-resistant overweight men (BM1 25-35 kg/m(2)). Methods In a cohort study we examined NEFA concentrations in men in the upper quartile of fasting insulin (n = 124) and in men with fasting insulin below the median (n 159). In a metabolic study we examined NEFA metabolism in the fasting and postprandial states, in ten insulin-resistant men and ten controls. Results In the cohort study, fasting NEFA concentrations were not significantly different between the two groups (median values: insulin-resistant men, 410 mu mol/l; controls, 445 2 mu mol/l). However, triacylglycerol concentrations differed markedly (1.84 vs 1.18 mmol/l respectively, p&lt;0.001). In the metabolic study, arterial NEFA concentrations again did not differ between groups, whereas triacylglycerol concentrations were significantly higher in insulin-resistant men. Systemic NEFA production and the release of NEFA from subcutaneous adipose tissue, expressed per unit of fat mass, were both reduced in insulin-resistant men compared with controls (fasting values by 32%, p=0.02, and 44%, p=0.04 respectively). 3-Hydroxybutyrate concentrations, an index of hepatic fat oxidation and ketogenesis, were lower (p=0.03). Conclusions/interpretation Adipose tissue NEFA output is not increased (per unit weight of tissue) in insulin resistance. On the contrary, it appears to be suppressed by high fasting insulin concentrations. Alterations in triacylglycerol metabolism are more marked than those in NEFA metabolism. and are indicative of altered metabolic partitioning of fatty acids (decreased oxidation, increased esterification) in the liver.},
  author       = {Bickerton, A. S. T. and Roberts, R. and Fielding, B. A. and Tornqvist, Hans and Blaak, E. E. and Wagenmakers, A. J. M. and Gilbert, M. and Humphreys, Keith and Karpe, F. and Frayn, K. N.},
  issn         = {1432-0428},
  keyword      = {non-esterified fatty acids,adipose tissue,insulin resistance,triacylglycerol},
  language     = {eng},
  number       = {8},
  pages        = {1466--1474},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Adipose tissue fatty acid metabolism in insulin-resistant men},
  url          = {http://dx.doi.org/10.1007/s00125-008-1040-x},
  volume       = {51},
  year         = {2008},
}