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Biomonitoring of lead exposure-alternatives to blood

Bergdahl, Ingvar A and Skerfving, Staffan LU (2008) In Journal of Toxicology and Environmental Health. Part A: Current Issues 71(18). p.1235-1243
Abstract
Lead (Pb) is one of the most important models for biomonitoring of exposure, with the blood Pb concentration as a predominant choice in practice and in epidemiology. In this article the alternatives for biomarkers to blood are reviewed. This overview focuses on a number of different qualities that are of importance in the evaluation of a biomarker's usefulness and performance. The qualities scrutinized included: (1) analytical accuracy and precision; (2) cost; (3) practical issues; (4) what is reflected by the biomarker; (5) relationship to exposure; and (6) relationship to effects. Data indicate that the best biomarker in some circumstances may be blood, but bone or teeth (for past exposures), feces (for current gastrointestinal... (More)
Lead (Pb) is one of the most important models for biomonitoring of exposure, with the blood Pb concentration as a predominant choice in practice and in epidemiology. In this article the alternatives for biomarkers to blood are reviewed. This overview focuses on a number of different qualities that are of importance in the evaluation of a biomarker's usefulness and performance. The qualities scrutinized included: (1) analytical accuracy and precision; (2) cost; (3) practical issues; (4) what is reflected by the biomarker; (5) relationship to exposure; and (6) relationship to effects. Data indicate that the best biomarker in some circumstances may be blood, but bone or teeth (for past exposures), feces (for current gastrointestinal exposure), or urine (for organic Pb) are sometimes more useful. A striking feature is that no generally accepted biomarker of bioavailable Pb exists, though plasma, bone, teeth, urine, and hair have all been discussed. For one of the most used applications of blood Pb, monitoring of lead workers' exposure, blood has important shortcomings in that it shows a poor response to changes in exposure at high levels. The alternative of plasma has not been sufficiently evaluated to be considered an alternative in occupational health services, although previous analytical problems are basically overcome. Possibly, urine deserves also more attention. Almost all biomarkers lack systematic data on variation within and between individuals. (Less)
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author
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type
Contribution to journal
publication status
published
subject
in
Journal of Toxicology and Environmental Health. Part A: Current Issues
volume
71
issue
18
pages
1235 - 1243
publisher
Taylor & Francis
external identifiers
  • wos:000257900100001
  • scopus:47949113714
ISSN
1087-2620
DOI
10.1080/15287390802209525
language
English
LU publication?
yes
id
837be3bb-535d-4b26-a32f-71d8b1f7e45a (old id 1253856)
date added to LUP
2008-11-07 14:36:03
date last changed
2017-11-12 03:31:29
@article{837be3bb-535d-4b26-a32f-71d8b1f7e45a,
  abstract     = {Lead (Pb) is one of the most important models for biomonitoring of exposure, with the blood Pb concentration as a predominant choice in practice and in epidemiology. In this article the alternatives for biomarkers to blood are reviewed. This overview focuses on a number of different qualities that are of importance in the evaluation of a biomarker's usefulness and performance. The qualities scrutinized included: (1) analytical accuracy and precision; (2) cost; (3) practical issues; (4) what is reflected by the biomarker; (5) relationship to exposure; and (6) relationship to effects. Data indicate that the best biomarker in some circumstances may be blood, but bone or teeth (for past exposures), feces (for current gastrointestinal exposure), or urine (for organic Pb) are sometimes more useful. A striking feature is that no generally accepted biomarker of bioavailable Pb exists, though plasma, bone, teeth, urine, and hair have all been discussed. For one of the most used applications of blood Pb, monitoring of lead workers' exposure, blood has important shortcomings in that it shows a poor response to changes in exposure at high levels. The alternative of plasma has not been sufficiently evaluated to be considered an alternative in occupational health services, although previous analytical problems are basically overcome. Possibly, urine deserves also more attention. Almost all biomarkers lack systematic data on variation within and between individuals.},
  author       = {Bergdahl, Ingvar A and Skerfving, Staffan},
  issn         = {1087-2620},
  language     = {eng},
  number       = {18},
  pages        = {1235--1243},
  publisher    = {Taylor & Francis},
  series       = {Journal of Toxicology and Environmental Health. Part A: Current Issues},
  title        = {Biomonitoring of lead exposure-alternatives to blood},
  url          = {http://dx.doi.org/10.1080/15287390802209525},
  volume       = {71},
  year         = {2008},
}