Production of glycidyl ethers by chemo-enzymatic epoxidation of allyl ethers
(2008) In Journal of Molecular Catalysis B: Enzymatic 54(1-2). p.1-6- Abstract
- Production of glycidyl ethers is industrially carried Out by reacting alcohols with epichlorhydrin, a potentially carcinogenic compound. This paper investigates a less hazardous alternative-that of a chemo-enzymatic process in which Candida antarctica lipase B catalysed generation of peracid from a carboxylic acid is followed by a Prileshajev epoxidation of the corresponding allyl ether. Trimethylolpropane monoallyl ether (TMPME) was used as a model substrate. A maximal epoxide product yield of 77% was achieved through the optimization of temperature. acid concentration and hydrogen peroxide concentration. Peracid formation was considerably faster than the subsequent epoxidation step, and accumulation of the peracid was Found to be... (More)
- Production of glycidyl ethers is industrially carried Out by reacting alcohols with epichlorhydrin, a potentially carcinogenic compound. This paper investigates a less hazardous alternative-that of a chemo-enzymatic process in which Candida antarctica lipase B catalysed generation of peracid from a carboxylic acid is followed by a Prileshajev epoxidation of the corresponding allyl ether. Trimethylolpropane monoallyl ether (TMPME) was used as a model substrate. A maximal epoxide product yield of 77% was achieved through the optimization of temperature. acid concentration and hydrogen peroxide concentration. Peracid formation was considerably faster than the subsequent epoxidation step, and accumulation of the peracid was Found to be important to drive the epoxidation forward. (C) 2008 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1254666
- author
- Tufvesson, Pär LU ; Adlercreutz, Dietlind LU ; Lundmark, Stefan ; Manea, Mircea and Hatti-Kaul, Rajni LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- lipase, allyl ether, epoxidation, glycidyl ether, peracid
- in
- Journal of Molecular Catalysis B: Enzymatic
- volume
- 54
- issue
- 1-2
- pages
- 1 - 6
- publisher
- Elsevier
- external identifiers
-
- wos:000257590000001
- scopus:44649189738
- ISSN
- 1873-3158
- DOI
- 10.1016/j.molcatb.2007.11.015
- language
- English
- LU publication?
- yes
- id
- 19d07118-98c0-414a-9a3a-e4958af8a624 (old id 1254666)
- date added to LUP
- 2016-04-01 12:12:15
- date last changed
- 2022-01-27 00:21:52
@article{19d07118-98c0-414a-9a3a-e4958af8a624,
abstract = {{Production of glycidyl ethers is industrially carried Out by reacting alcohols with epichlorhydrin, a potentially carcinogenic compound. This paper investigates a less hazardous alternative-that of a chemo-enzymatic process in which Candida antarctica lipase B catalysed generation of peracid from a carboxylic acid is followed by a Prileshajev epoxidation of the corresponding allyl ether. Trimethylolpropane monoallyl ether (TMPME) was used as a model substrate. A maximal epoxide product yield of 77% was achieved through the optimization of temperature. acid concentration and hydrogen peroxide concentration. Peracid formation was considerably faster than the subsequent epoxidation step, and accumulation of the peracid was Found to be important to drive the epoxidation forward. (C) 2008 Elsevier B.V. All rights reserved.}},
author = {{Tufvesson, Pär and Adlercreutz, Dietlind and Lundmark, Stefan and Manea, Mircea and Hatti-Kaul, Rajni}},
issn = {{1873-3158}},
keywords = {{lipase; allyl ether; epoxidation; glycidyl ether; peracid}},
language = {{eng}},
number = {{1-2}},
pages = {{1--6}},
publisher = {{Elsevier}},
series = {{Journal of Molecular Catalysis B: Enzymatic}},
title = {{Production of glycidyl ethers by chemo-enzymatic epoxidation of allyl ethers}},
url = {{https://lup.lub.lu.se/search/files/2825436/1268339.pdf}},
doi = {{10.1016/j.molcatb.2007.11.015}},
volume = {{54}},
year = {{2008}},
}