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Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress

Ganfornina, Maria D.; Do Carmo, Sonia; Lora, Jose M.; Torres-Schumann, Sonia; Vogel, Marci; Allhorn, Maria LU ; Gonzalez, Constancio; Bastiani, Michael J.; Rassart, Eric and Sanchez, Diego (2008) In Aging Cell 7(4). p.506-515
Abstract
Many nervous system pathologies are associated with increased levels of apolipoprotein D (ApoD), a lipocalin also expressed during normal development and aging. An ApoD homologous gene in Drosophila, Glial Lazarillo, regulates resistance to stress, and neurodegeneration in the aging brain. Here we study for the first time the protective potential of ApoD in a vertebrate model organism. Loss of mouse ApoD function increases the sensitivity to oxidative stress and the levels of brain lipid peroxidation, and impairs locomotor and learning abilities. Human ApoD overexpression in the mouse brain produces opposite effects, increasing survival and preventing the raise of brain lipid peroxides after oxidant treatment. These observations, together... (More)
Many nervous system pathologies are associated with increased levels of apolipoprotein D (ApoD), a lipocalin also expressed during normal development and aging. An ApoD homologous gene in Drosophila, Glial Lazarillo, regulates resistance to stress, and neurodegeneration in the aging brain. Here we study for the first time the protective potential of ApoD in a vertebrate model organism. Loss of mouse ApoD function increases the sensitivity to oxidative stress and the levels of brain lipid peroxidation, and impairs locomotor and learning abilities. Human ApoD overexpression in the mouse brain produces opposite effects, increasing survival and preventing the raise of brain lipid peroxides after oxidant treatment. These observations, together with its transcriptional up-regulation in the brain upon oxidative insult, identify ApoD as an acute response protein with a protective and therefore beneficial function mediated by the control of peroxidated lipids. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
paraquat, locomotor behavior, lipocalin, learning, lipid peroxidation, oxidative stress
in
Aging Cell
volume
7
issue
4
pages
506 - 515
publisher
Wiley-Blackwell
external identifiers
  • wos:000257513500008
  • scopus:47349099698
ISSN
1474-9726
DOI
10.1111/j.1474-9726.2008.00395.x
language
English
LU publication?
yes
id
bac652f6-a941-457d-81c4-3235a22f8d02 (old id 1255227)
date added to LUP
2008-10-16 13:43:03
date last changed
2017-11-12 03:27:08
@article{bac652f6-a941-457d-81c4-3235a22f8d02,
  abstract     = {Many nervous system pathologies are associated with increased levels of apolipoprotein D (ApoD), a lipocalin also expressed during normal development and aging. An ApoD homologous gene in Drosophila, Glial Lazarillo, regulates resistance to stress, and neurodegeneration in the aging brain. Here we study for the first time the protective potential of ApoD in a vertebrate model organism. Loss of mouse ApoD function increases the sensitivity to oxidative stress and the levels of brain lipid peroxidation, and impairs locomotor and learning abilities. Human ApoD overexpression in the mouse brain produces opposite effects, increasing survival and preventing the raise of brain lipid peroxides after oxidant treatment. These observations, together with its transcriptional up-regulation in the brain upon oxidative insult, identify ApoD as an acute response protein with a protective and therefore beneficial function mediated by the control of peroxidated lipids.},
  author       = {Ganfornina, Maria D. and Do Carmo, Sonia and Lora, Jose M. and Torres-Schumann, Sonia and Vogel, Marci and Allhorn, Maria and Gonzalez, Constancio and Bastiani, Michael J. and Rassart, Eric and Sanchez, Diego},
  issn         = {1474-9726},
  keyword      = {paraquat,locomotor behavior,lipocalin,learning,lipid peroxidation,oxidative stress},
  language     = {eng},
  number       = {4},
  pages        = {506--515},
  publisher    = {Wiley-Blackwell},
  series       = {Aging Cell},
  title        = {Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress},
  url          = {http://dx.doi.org/10.1111/j.1474-9726.2008.00395.x},
  volume       = {7},
  year         = {2008},
}