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Mechanism of NADH transfer among dehydrogenases

Martinez Arias, Wilma LU ; Pettersson, Henrik LU and Pettersson, Gösta LU (1998) In BBA - Protein Structure and Molecular Enzymology 1385(1). p.149-156
Abstract
Steady-state and transient-state kinetic experiments have been performed to test the proposal that there is a direct (channelled) transfer of NADH from one dehydrogenase to another if the two enzymes exhibit distinct chiral coenzyme specificity (A-side vs. B-side). The results lend no support to this proposal, but are fully consistent with a free-diffusion mechanism of NADH transfer irrespective of the chiral specificity of the enzymes.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dehydrogenase, Channelling, Enzyme kinetics
in
BBA - Protein Structure and Molecular Enzymology
volume
1385
issue
1
pages
149 - 156
publisher
Elsevier
external identifiers
  • scopus:0031807288
ISSN
0167-4838
DOI
10.1016/S0167-4838(98)00035-1
language
English
LU publication?
yes
id
cb895932-5e7f-4d28-aff8-40d5ba9249e4 (old id 125567)
alternative location
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T21-3T1BX85-J&_user=745831&_coverDate=06%2F11%2F1998&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000041498&_version=1&_urlVersion=0&_userid=745831&md5=24580464b263977f32200263048dd1ff&searchtype=a
date added to LUP
2007-07-06 11:57:19
date last changed
2017-01-01 06:54:58
@article{cb895932-5e7f-4d28-aff8-40d5ba9249e4,
  abstract     = {Steady-state and transient-state kinetic experiments have been performed to test the proposal that there is a direct (channelled) transfer of NADH from one dehydrogenase to another if the two enzymes exhibit distinct chiral coenzyme specificity (A-side vs. B-side). The results lend no support to this proposal, but are fully consistent with a free-diffusion mechanism of NADH transfer irrespective of the chiral specificity of the enzymes.},
  author       = {Martinez Arias, Wilma and Pettersson, Henrik and Pettersson, Gösta},
  issn         = {0167-4838},
  keyword      = {Dehydrogenase,Channelling,Enzyme kinetics},
  language     = {eng},
  number       = {1},
  pages        = {149--156},
  publisher    = {Elsevier},
  series       = {BBA - Protein Structure and Molecular Enzymology},
  title        = {Mechanism of NADH transfer among dehydrogenases},
  url          = {http://dx.doi.org/10.1016/S0167-4838(98)00035-1},
  volume       = {1385},
  year         = {1998},
}