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Basic helix-loop-helix proteins expressed during early embryonic organogenesis.

Hjalt, Tord LU (2004) In International Review of Cytology 236. p.251-280
Abstract
The basic helix–loop–helix proteins form a special group of transcription factors unique for the eukaryotic organisms. They are crucial for the embryonic development of many fundamental organ systems such as muscle, heart, central nervous system, hematopoiteic system, and many others. They are very flexible in terms of regulating transcription in that they can either promote or repress transcription, and do so in many different ways. Basic helix–loop–helix proteins can form homo- or heterodimers with other members of the group, and are subject to post-transcriptional modifications. In this review, an overview of basic helix–loop–helix protein classification, biochemical function, and examples of past and recent advances in our... (More)
The basic helix–loop–helix proteins form a special group of transcription factors unique for the eukaryotic organisms. They are crucial for the embryonic development of many fundamental organ systems such as muscle, heart, central nervous system, hematopoiteic system, and many others. They are very flexible in terms of regulating transcription in that they can either promote or repress transcription, and do so in many different ways. Basic helix–loop–helix proteins can form homo- or heterodimers with other members of the group, and are subject to post-transcriptional modifications. In this review, an overview of basic helix–loop–helix protein classification, biochemical function, and examples of past and recent advances in our understanding of embryonic development are presented, with emphasis on the vertebrate muscle, heart, brain, and eye. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Development, Organogenesis, Embryogenesis, Basic helix–loop–helix, bHLH, Differentiation
in
International Review of Cytology
volume
236
pages
251 - 280
publisher
Elsevier
external identifiers
  • wos:000223742500006
  • pmid:15261740
  • scopus:3142736512
ISSN
0074-7696
DOI
10.1016/S0074-7696(04)36006-7
language
English
LU publication?
yes
id
c0e2bbca-9e78-4b02-b1be-4544bbd44a04 (old id 125767)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15261740&dopt=Abstract
date added to LUP
2007-07-13 11:34:00
date last changed
2017-11-30 11:21:36
@article{c0e2bbca-9e78-4b02-b1be-4544bbd44a04,
  abstract     = {The basic helix–loop–helix proteins form a special group of transcription factors unique for the eukaryotic organisms. They are crucial for the embryonic development of many fundamental organ systems such as muscle, heart, central nervous system, hematopoiteic system, and many others. They are very flexible in terms of regulating transcription in that they can either promote or repress transcription, and do so in many different ways. Basic helix–loop–helix proteins can form homo- or heterodimers with other members of the group, and are subject to post-transcriptional modifications. In this review, an overview of basic helix–loop–helix protein classification, biochemical function, and examples of past and recent advances in our understanding of embryonic development are presented, with emphasis on the vertebrate muscle, heart, brain, and eye.},
  author       = {Hjalt, Tord},
  issn         = {0074-7696},
  keyword      = {Development,Organogenesis,Embryogenesis,Basic helix–loop–helix,bHLH,Differentiation},
  language     = {eng},
  pages        = {251--280},
  publisher    = {Elsevier},
  series       = {International Review of Cytology},
  title        = {Basic helix-loop-helix proteins expressed during early embryonic organogenesis.},
  url          = {http://dx.doi.org/10.1016/S0074-7696(04)36006-7},
  volume       = {236},
  year         = {2004},
}