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The Pro12Ala polymorphism of the PPARG gene is not associated with the metabolic syndrome in an urban population of middle-aged Swedish individuals.

Montagnana, Martina LU ; Fava, Cristiano LU ; Nilsson, Peter LU ; Engström, Gunnar LU ; Hedblad, Bo LU ; Lippi, G; Minuz, P; Berglund, Göran LU and Melander, Olle LU (2008) In Diabetic medicine : a journal of the British Diabetic Association 25(8). p.902-908
Abstract
BACKGROUND: To determine if the common Pro12Ala polymorphism (rs1801282) of the peroxisome proliferator-activated receptor (PPARG) gene is associated with the metabolic syndrome (MetS) or with its individual components in middle-aged Swedish individuals. METHODS: MetS was defined according to the National Cholesterol Education Program/Adult Panel III (NCEP/ATP III), the International Diabetes Federation (IDF) and the European Group for the Study of Insulin Resistance (EGIR) criteria in a population-based sample of nearly 5000 subjects participating in the Malmö Diet and Cancer-cardiovascular arm. RESULTS: Of the subjects included in the analysis, 21.8, 29.4 and 20.4% had MetS according to the NCEP/ATP III, IDF and EGIR (only in subjects... (More)
BACKGROUND: To determine if the common Pro12Ala polymorphism (rs1801282) of the peroxisome proliferator-activated receptor (PPARG) gene is associated with the metabolic syndrome (MetS) or with its individual components in middle-aged Swedish individuals. METHODS: MetS was defined according to the National Cholesterol Education Program/Adult Panel III (NCEP/ATP III), the International Diabetes Federation (IDF) and the European Group for the Study of Insulin Resistance (EGIR) criteria in a population-based sample of nearly 5000 subjects participating in the Malmö Diet and Cancer-cardiovascular arm. RESULTS: Of the subjects included in the analysis, 21.8, 29.4 and 20.4% had MetS according to the NCEP/ATP III, IDF and EGIR (only in subjects without diabetes) definitions, respectively. The Pro12Ala was not associated with MetS or with its individual components. These results were similar when patients with diabetes were excluded. Hypertensive and obese ala-carriers had lower fasting glucose and hypertensive ala-carriers also had lower level triglycerides (P < 0.05). CONCLUSIONS: Our data do not support a major role for the Pro12Ala variant of the PPARG gene in MetS and its individual components. The modest difference in triglyceride and glucose levels, restricted to hypertensive and obese subjects in our cohort, suggests that the polymorphism has a minor effect on glucose and lipid metabolism, particularly in individuals at risk for gluco-metabolic disturbances. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
association, genetics, Pro12Ala polymorphism, proliferator-activated receptor-gamma, peroxisome, metabolic syndrome
in
Diabetic medicine : a journal of the British Diabetic Association
volume
25
issue
8
pages
902 - 908
publisher
Wiley-Blackwell
external identifiers
  • wos:000257987800004
  • pmid:18959602
  • scopus:48149088301
ISSN
1464-5491
DOI
10.1111/j.1464-5491.2008.02510.x
language
English
LU publication?
yes
id
a8b9b129-9c0a-417c-906a-95b7527ffc05 (old id 1261803)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18959602?dopt=Abstract
date added to LUP
2008-11-04 12:11:45
date last changed
2017-08-13 04:09:16
@article{a8b9b129-9c0a-417c-906a-95b7527ffc05,
  abstract     = {BACKGROUND: To determine if the common Pro12Ala polymorphism (rs1801282) of the peroxisome proliferator-activated receptor (PPARG) gene is associated with the metabolic syndrome (MetS) or with its individual components in middle-aged Swedish individuals. METHODS: MetS was defined according to the National Cholesterol Education Program/Adult Panel III (NCEP/ATP III), the International Diabetes Federation (IDF) and the European Group for the Study of Insulin Resistance (EGIR) criteria in a population-based sample of nearly 5000 subjects participating in the Malmö Diet and Cancer-cardiovascular arm. RESULTS: Of the subjects included in the analysis, 21.8, 29.4 and 20.4% had MetS according to the NCEP/ATP III, IDF and EGIR (only in subjects without diabetes) definitions, respectively. The Pro12Ala was not associated with MetS or with its individual components. These results were similar when patients with diabetes were excluded. Hypertensive and obese ala-carriers had lower fasting glucose and hypertensive ala-carriers also had lower level triglycerides (P &lt; 0.05). CONCLUSIONS: Our data do not support a major role for the Pro12Ala variant of the PPARG gene in MetS and its individual components. The modest difference in triglyceride and glucose levels, restricted to hypertensive and obese subjects in our cohort, suggests that the polymorphism has a minor effect on glucose and lipid metabolism, particularly in individuals at risk for gluco-metabolic disturbances.},
  author       = {Montagnana, Martina and Fava, Cristiano and Nilsson, Peter and Engström, Gunnar and Hedblad, Bo and Lippi, G and Minuz, P and Berglund, Göran and Melander, Olle},
  issn         = {1464-5491},
  keyword      = {association,genetics,Pro12Ala polymorphism,proliferator-activated receptor-gamma,peroxisome,metabolic syndrome},
  language     = {eng},
  number       = {8},
  pages        = {902--908},
  publisher    = {Wiley-Blackwell},
  series       = {Diabetic medicine : a journal of the British Diabetic Association},
  title        = {The Pro12Ala polymorphism of the PPARG gene is not associated with the metabolic syndrome in an urban population of middle-aged Swedish individuals.},
  url          = {http://dx.doi.org/10.1111/j.1464-5491.2008.02510.x},
  volume       = {25},
  year         = {2008},
}