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Expression of the novel gene Ened during mouse and Xenopus embryonic development.

Gustafsson, Renata LU ; Strate, Ina LU ; Pera, Edgar LU and Durbeej-Hjalt, Madeleine LU (2008) In International Journal of Developmental Biology 52(8). p.1119-1122
Abstract
We have recently identified 1110032E23Rik as a down-regulated target gene in Fgf receptor-signalling-deficient mouse embryoid bodies. Here, we present the expression pattern of this novel gene, designated Ened (Expressed in Nerve and Epithelium during Development), in mouse and Xenopus laevis embryos. Murine Ened transcripts were first seen at E9.5 in the heart and the gastrointestinal tract. At later stages of gestation, expression could be found in the floor plate, peripheral nervous system, lens epithelium, skin, midline dorsal aorta, lung, kidney and testis. In Xenopus, the expression of the Ened orthologue displayed common RNA distribution in several ectodermal and mesodermal tissues, but also distinct expression in locations... (More)
We have recently identified 1110032E23Rik as a down-regulated target gene in Fgf receptor-signalling-deficient mouse embryoid bodies. Here, we present the expression pattern of this novel gene, designated Ened (Expressed in Nerve and Epithelium during Development), in mouse and Xenopus laevis embryos. Murine Ened transcripts were first seen at E9.5 in the heart and the gastrointestinal tract. At later stages of gestation, expression could be found in the floor plate, peripheral nervous system, lens epithelium, skin, midline dorsal aorta, lung, kidney and testis. In Xenopus, the expression of the Ened orthologue displayed common RNA distribution in several ectodermal and mesodermal tissues, but also distinct expression in locations including the brain, notochord and blood islands. We suggest that Ened might be a novel target gene of the Fgfr signalling pathway during embryonic development, and that its expression could be modulated by the basement membrane component laminin-111. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Developmental Biology
volume
52
issue
8
pages
1119 - 1122
publisher
U B C Press
external identifiers
  • wos:000262153300013
  • pmid:18956345
  • scopus:61449530989
ISSN
1696-3547
DOI
10.1387/ijdb.082700rm
language
English
LU publication?
yes
id
b556368e-1c9c-4cc7-ac1b-100921a2840b (old id 1261867)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18956345?dopt=Abstract
date added to LUP
2008-11-04 11:29:51
date last changed
2017-01-01 07:31:15
@article{b556368e-1c9c-4cc7-ac1b-100921a2840b,
  abstract     = {We have recently identified 1110032E23Rik as a down-regulated target gene in Fgf receptor-signalling-deficient mouse embryoid bodies. Here, we present the expression pattern of this novel gene, designated Ened (Expressed in Nerve and Epithelium during Development), in mouse and Xenopus laevis embryos. Murine Ened transcripts were first seen at E9.5 in the heart and the gastrointestinal tract. At later stages of gestation, expression could be found in the floor plate, peripheral nervous system, lens epithelium, skin, midline dorsal aorta, lung, kidney and testis. In Xenopus, the expression of the Ened orthologue displayed common RNA distribution in several ectodermal and mesodermal tissues, but also distinct expression in locations including the brain, notochord and blood islands. We suggest that Ened might be a novel target gene of the Fgfr signalling pathway during embryonic development, and that its expression could be modulated by the basement membrane component laminin-111.},
  author       = {Gustafsson, Renata and Strate, Ina and Pera, Edgar and Durbeej-Hjalt, Madeleine},
  issn         = {1696-3547},
  language     = {eng},
  number       = {8},
  pages        = {1119--1122},
  publisher    = {U B C Press},
  series       = {International Journal of Developmental Biology},
  title        = {Expression of the novel gene Ened during mouse and Xenopus embryonic development.},
  url          = {http://dx.doi.org/10.1387/ijdb.082700rm},
  volume       = {52},
  year         = {2008},
}