The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1.
(2008) In Oncology Reports 20(5). p.1029-1033- Abstract
- POU5F1, which encodes a transcriptional factor, has two alternatively spliced transcripts, 1 and 2, as well as six pseudogenes. Transcript 1 is considered to be a key regulator of cellular pluripotency and self-renewal. The POU5F1 pseudogene, POU5F1P1 on 8q24, encodes a protein with 95% homology with the isoform 1 of POU5F1. It is located 15 kbp downstream of the SNP rs6983267, which is strongly associated with an increased risk of prostate and colon cancer, and within the amplified region in a variety of human malignancies. The previous finding of expressed sequence tags suggests that POU5F1P1 can be expressed. We showed that a putative POU5F1P1 protein is localized in the nucleus, acts as a transcriptional activator and regulates the... (More)
- POU5F1, which encodes a transcriptional factor, has two alternatively spliced transcripts, 1 and 2, as well as six pseudogenes. Transcript 1 is considered to be a key regulator of cellular pluripotency and self-renewal. The POU5F1 pseudogene, POU5F1P1 on 8q24, encodes a protein with 95% homology with the isoform 1 of POU5F1. It is located 15 kbp downstream of the SNP rs6983267, which is strongly associated with an increased risk of prostate and colon cancer, and within the amplified region in a variety of human malignancies. The previous finding of expressed sequence tags suggests that POU5F1P1 can be expressed. We showed that a putative POU5F1P1 protein is localized in the nucleus, acts as a transcriptional activator and regulates the expression in a similar way to the POU5F1 isoform 1. However, POU5F1P1 was a weaker activator than isoform 1 of POU5F1, possibly due to the amino acid substitutions. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1262005
- author
- Panagopoulos, Ioannis LU ; Möller, Emely LU ; Collin, Anna LU and Mertens, Fredrik LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Oncology Reports
- volume
- 20
- issue
- 5
- pages
- 1029 - 1033
- publisher
- Spandidos Publications
- external identifiers
-
- wos:000260648200005
- pmid:18949397
- scopus:58149329044
- ISSN
- 1791-2431
- DOI
- 10.3892/or_00000105
- language
- English
- LU publication?
- yes
- id
- 6a4d0aff-8c62-4491-8dcc-b5dc84c85912 (old id 1262005)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18949397?dopt=Abstract
- date added to LUP
- 2016-04-04 09:17:44
- date last changed
- 2022-03-31 01:58:06
@article{6a4d0aff-8c62-4491-8dcc-b5dc84c85912,
abstract = {{POU5F1, which encodes a transcriptional factor, has two alternatively spliced transcripts, 1 and 2, as well as six pseudogenes. Transcript 1 is considered to be a key regulator of cellular pluripotency and self-renewal. The POU5F1 pseudogene, POU5F1P1 on 8q24, encodes a protein with 95% homology with the isoform 1 of POU5F1. It is located 15 kbp downstream of the SNP rs6983267, which is strongly associated with an increased risk of prostate and colon cancer, and within the amplified region in a variety of human malignancies. The previous finding of expressed sequence tags suggests that POU5F1P1 can be expressed. We showed that a putative POU5F1P1 protein is localized in the nucleus, acts as a transcriptional activator and regulates the expression in a similar way to the POU5F1 isoform 1. However, POU5F1P1 was a weaker activator than isoform 1 of POU5F1, possibly due to the amino acid substitutions.}},
author = {{Panagopoulos, Ioannis and Möller, Emely and Collin, Anna and Mertens, Fredrik}},
issn = {{1791-2431}},
language = {{eng}},
number = {{5}},
pages = {{1029--1033}},
publisher = {{Spandidos Publications}},
series = {{Oncology Reports}},
title = {{The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1.}},
url = {{http://dx.doi.org/10.3892/or_00000105}},
doi = {{10.3892/or_00000105}},
volume = {{20}},
year = {{2008}},
}