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Maternal transfer of antibodies in vertebrates: trans-generational effects on offspring immunity.

Hasselquist, Dennis LU and Nilsson, Jan-Åke LU (2009) In Royal Society of London. Philosophical Transactions B. Biological Sciences 364(1513). p.51-60
Abstract
Maternal effects by which females provide their offspring with non-genetic factors such as hormones, nutrients and antibodies can have an important impact on offspring fitness. In vertebrates, maternal antibodies (matAb) are transferred from the mother, via the placenta, egg yolk or milk during lactation to offspring until they are 2 weeks (birds), 4-10 weeks (rodents) and 9 months (humans) old, respectively. matAb transfer can have direct effects on offspring growth rate in birds and rodents, probably by passively protecting the newborn from common pathogens before their endogenous immune system has matured. Indirect long-term effects of matAb transfer on the offspring's own immunity can be synergistic, if matAb act as antigen templates... (More)
Maternal effects by which females provide their offspring with non-genetic factors such as hormones, nutrients and antibodies can have an important impact on offspring fitness. In vertebrates, maternal antibodies (matAb) are transferred from the mother, via the placenta, egg yolk or milk during lactation to offspring until they are 2 weeks (birds), 4-10 weeks (rodents) and 9 months (humans) old, respectively. matAb transfer can have direct effects on offspring growth rate in birds and rodents, probably by passively protecting the newborn from common pathogens before their endogenous immune system has matured. Indirect long-term effects of matAb transfer on the offspring's own immunity can be synergistic, if matAb act as antigen templates of the accumulated immunological experience of the mother and educate the newborn's immune system. However, it may also be suppressive if matAb reduce antigen presentation to the newborn resulting in antigen-specific blocking of offspring endogenous immunity. Our aim is to review the mechanisms and direct effects of matAb transfer in vertebrates with an emphasis on birds, outline a framework for research on the long-term effects of matAb on the endogenous immune system of the mature offspring and encourage ecological and evolutionary studies of matAb transfer in non-domesticated animals. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
maternal effects, offspring growth rate, epitope blocking, trans-generational effects, immune system priming, maternal antibody transfer
in
Royal Society of London. Philosophical Transactions B. Biological Sciences
volume
364
issue
1513
pages
51 - 60
publisher
Royal Society
external identifiers
  • wos:000261150600005
  • scopus:58249086767
ISSN
1471-2970
DOI
10.1098/rstb.2008.0137
project
Costs of the immune system and maternal effects
language
English
LU publication?
yes
id
a2b36991-5bf0-4c9a-af11-373e066cac4d (old id 1262157)
date added to LUP
2008-11-27 12:58:42
date last changed
2017-08-06 03:31:34
@article{a2b36991-5bf0-4c9a-af11-373e066cac4d,
  abstract     = {Maternal effects by which females provide their offspring with non-genetic factors such as hormones, nutrients and antibodies can have an important impact on offspring fitness. In vertebrates, maternal antibodies (matAb) are transferred from the mother, via the placenta, egg yolk or milk during lactation to offspring until they are 2 weeks (birds), 4-10 weeks (rodents) and 9 months (humans) old, respectively. matAb transfer can have direct effects on offspring growth rate in birds and rodents, probably by passively protecting the newborn from common pathogens before their endogenous immune system has matured. Indirect long-term effects of matAb transfer on the offspring's own immunity can be synergistic, if matAb act as antigen templates of the accumulated immunological experience of the mother and educate the newborn's immune system. However, it may also be suppressive if matAb reduce antigen presentation to the newborn resulting in antigen-specific blocking of offspring endogenous immunity. Our aim is to review the mechanisms and direct effects of matAb transfer in vertebrates with an emphasis on birds, outline a framework for research on the long-term effects of matAb on the endogenous immune system of the mature offspring and encourage ecological and evolutionary studies of matAb transfer in non-domesticated animals.},
  author       = {Hasselquist, Dennis and Nilsson, Jan-Åke},
  issn         = {1471-2970},
  keyword      = {maternal effects,offspring growth rate,epitope blocking,trans-generational effects,immune system priming,maternal antibody transfer},
  language     = {eng},
  number       = {1513},
  pages        = {51--60},
  publisher    = {Royal Society},
  series       = {Royal Society of London. Philosophical Transactions B. Biological Sciences},
  title        = {Maternal transfer of antibodies in vertebrates: trans-generational effects on offspring immunity.},
  url          = {http://dx.doi.org/10.1098/rstb.2008.0137},
  volume       = {364},
  year         = {2009},
}