Decomposing health: tolerance and resistance to parasites in animals.
(2009) In Philosophical Transactions of the Royal Society B: Biological Sciences 364(1513). p.37-49- Abstract
- Plant biologists have long recognized that host defence against parasites and pathogens can be divided into two conceptually different components: the ability to limit parasite burden (resistance) and the ability to limit the harm caused by a given burden (tolerance). Together these two components determine how well a host is protected against the effects of parasitism. This distinction is useful because it recognizes that hosts that are best at controlling parasite burdens are not necessarily the healthiest. Moreover, resistance and tolerance can be expected to have different effects on the epidemiology of infectious diseases and host-parasite coevolution. However, studies of defence in animals have to date focused on resistance, whereas... (More)
- Plant biologists have long recognized that host defence against parasites and pathogens can be divided into two conceptually different components: the ability to limit parasite burden (resistance) and the ability to limit the harm caused by a given burden (tolerance). Together these two components determine how well a host is protected against the effects of parasitism. This distinction is useful because it recognizes that hosts that are best at controlling parasite burdens are not necessarily the healthiest. Moreover, resistance and tolerance can be expected to have different effects on the epidemiology of infectious diseases and host-parasite coevolution. However, studies of defence in animals have to date focused on resistance, whereas the possibility of tolerance and its implications have been largely overlooked. The aim of our review is to (i) describe the statistical framework for analysis of tolerance developed in plant science and how this can be applied to animals, (ii) review evidence of genetic and environmental variation for tolerance in animals, and studies indicating which mechanisms could contribute to this variation, and (iii) outline avenues for future research on this topic. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1262162
- author
- Råberg, Lars LU ; Graham, Andrea L and Read, Andrew F
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- tolerance, virulence, infectious disease, resistance, immunopathology
- in
- Philosophical Transactions of the Royal Society B: Biological Sciences
- volume
- 364
- issue
- 1513
- pages
- 37 - 49
- publisher
- Royal Society Publishing
- external identifiers
-
- wos:000261150600004
- scopus:58149153179
- pmid:18926971
- ISSN
- 1471-2970
- DOI
- 10.1098/rstb.2008.0184
- language
- English
- LU publication?
- yes
- id
- d8fbe01d-6497-488f-a581-a590ecf31af4 (old id 1262162)
- date added to LUP
- 2016-04-01 13:53:21
- date last changed
- 2024-05-09 13:30:15
@article{d8fbe01d-6497-488f-a581-a590ecf31af4,
abstract = {{Plant biologists have long recognized that host defence against parasites and pathogens can be divided into two conceptually different components: the ability to limit parasite burden (resistance) and the ability to limit the harm caused by a given burden (tolerance). Together these two components determine how well a host is protected against the effects of parasitism. This distinction is useful because it recognizes that hosts that are best at controlling parasite burdens are not necessarily the healthiest. Moreover, resistance and tolerance can be expected to have different effects on the epidemiology of infectious diseases and host-parasite coevolution. However, studies of defence in animals have to date focused on resistance, whereas the possibility of tolerance and its implications have been largely overlooked. The aim of our review is to (i) describe the statistical framework for analysis of tolerance developed in plant science and how this can be applied to animals, (ii) review evidence of genetic and environmental variation for tolerance in animals, and studies indicating which mechanisms could contribute to this variation, and (iii) outline avenues for future research on this topic.}},
author = {{Råberg, Lars and Graham, Andrea L and Read, Andrew F}},
issn = {{1471-2970}},
keywords = {{tolerance; virulence; infectious disease; resistance; immunopathology}},
language = {{eng}},
number = {{1513}},
pages = {{37--49}},
publisher = {{Royal Society Publishing}},
series = {{Philosophical Transactions of the Royal Society B: Biological Sciences}},
title = {{Decomposing health: tolerance and resistance to parasites in animals.}},
url = {{http://dx.doi.org/10.1098/rstb.2008.0184}},
doi = {{10.1098/rstb.2008.0184}},
volume = {{364}},
year = {{2009}},
}