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Can DXA Predict Fractures in Renal Transplant Patients?

Akaberi, Shahriar LU ; Simonsen, Ole LU ; Lindergård, Birger LU and Nyberg, G (2008) In American Journal of Transplantation 8(12). p.2647-2651
Abstract
Renal transplant patients have a high prevalence of osteopenia, osteoporosis and fractures. The aim of the study was to investigate whether dual-energy x-ray absorptiometry (DXA) is of value to predict fractures. In 1995-2007, 238 renal transplant patients underwent 670 DXA investigations. Osteopenia (46.0%), osteoporosis (13.9%) and absolute bone mineral density (BMD) (median 0.9, range 0.4-2.0 g/cm(2)) in the hip region were used to evaluate fracture risk. Data on fractures were collected at the occasion of each DXA, and a questionnaire was filled in by 191 patients at regular outpatient visits. Reported fractures were verified by consultation of medical records. In all, 46 patients had 53 fractures. Cumulative hazard of fracture was... (More)
Renal transplant patients have a high prevalence of osteopenia, osteoporosis and fractures. The aim of the study was to investigate whether dual-energy x-ray absorptiometry (DXA) is of value to predict fractures. In 1995-2007, 238 renal transplant patients underwent 670 DXA investigations. Osteopenia (46.0%), osteoporosis (13.9%) and absolute bone mineral density (BMD) (median 0.9, range 0.4-2.0 g/cm(2)) in the hip region were used to evaluate fracture risk. Data on fractures were collected at the occasion of each DXA, and a questionnaire was filled in by 191 patients at regular outpatient visits. Reported fractures were verified by consultation of medical records. In all, 46 patients had 53 fractures. Cumulative hazard of fracture was significantly different among normal BMD, osteopenia and osteoporosis in the hip (p < 0.0001). A Cox proportional hazard analysis also including age, gender and diabetic nephropathy showed significantly increased fracture risk for osteoporosis (3.5 times, CI 1.8-6.4, p = 0.0001) as well as for osteopenia (2.7 times, 1.6-4.6, p = 0.0003). A significantly increased risk was also found with absolute BMD estimates below the median. Osteopenia and an absolute bone density below 0.9 g/cm(2) in the hip region confer an increased risk of fracture. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
diabetes mellitus, Bone mineral density, female, hyperparathyrodism, osteopenia, osteoporosis, renal allograft
in
American Journal of Transplantation
volume
8
issue
12
pages
2647 - 2651
publisher
Wiley-Blackwell
external identifiers
  • wos:000261053600024
  • pmid:18853956
  • scopus:56049089905
ISSN
1600-6135
DOI
10.1111/j.1600-6143.2008.02423.x
language
English
LU publication?
yes
id
175b965b-1d53-4ae2-b5f1-73588ec68eac (old id 1262212)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18853956?dopt=Abstract
date added to LUP
2008-11-03 13:20:55
date last changed
2017-08-20 03:47:46
@article{175b965b-1d53-4ae2-b5f1-73588ec68eac,
  abstract     = {Renal transplant patients have a high prevalence of osteopenia, osteoporosis and fractures. The aim of the study was to investigate whether dual-energy x-ray absorptiometry (DXA) is of value to predict fractures. In 1995-2007, 238 renal transplant patients underwent 670 DXA investigations. Osteopenia (46.0%), osteoporosis (13.9%) and absolute bone mineral density (BMD) (median 0.9, range 0.4-2.0 g/cm(2)) in the hip region were used to evaluate fracture risk. Data on fractures were collected at the occasion of each DXA, and a questionnaire was filled in by 191 patients at regular outpatient visits. Reported fractures were verified by consultation of medical records. In all, 46 patients had 53 fractures. Cumulative hazard of fracture was significantly different among normal BMD, osteopenia and osteoporosis in the hip (p &lt; 0.0001). A Cox proportional hazard analysis also including age, gender and diabetic nephropathy showed significantly increased fracture risk for osteoporosis (3.5 times, CI 1.8-6.4, p = 0.0001) as well as for osteopenia (2.7 times, 1.6-4.6, p = 0.0003). A significantly increased risk was also found with absolute BMD estimates below the median. Osteopenia and an absolute bone density below 0.9 g/cm(2) in the hip region confer an increased risk of fracture.},
  author       = {Akaberi, Shahriar and Simonsen, Ole and Lindergård, Birger and Nyberg, G},
  issn         = {1600-6135},
  keyword      = {diabetes mellitus,Bone mineral density,female,hyperparathyrodism,osteopenia,osteoporosis,renal allograft},
  language     = {eng},
  number       = {12},
  pages        = {2647--2651},
  publisher    = {Wiley-Blackwell},
  series       = {American Journal of Transplantation},
  title        = {Can DXA Predict Fractures in Renal Transplant Patients?},
  url          = {http://dx.doi.org/10.1111/j.1600-6143.2008.02423.x},
  volume       = {8},
  year         = {2008},
}