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Homocystein--markör för kärlsjukdom hos aldre med psykisk sjukdom.

Hultberg, Björn LU ; Nilsson, Anna-Karin LU and Gustafson, Lars (2008) In Läkartidningen 105(38). p.2576-2578
Abstract
Many studies have reported higher total plasma homocysteine (tHcy) in elderly patients with mental illness than in control subjects. There are many different determinants of plasma tHcy concentration, including age, cobalamin/folate status, renal function and the presence of vascular disease. The presence of vascular disease may contribute to cognitive impairment. We have investigated elderly patients with regard to plasma tHcy and the presence of vascular disease. Clarification of the role of vascular risk factors in mental illness is important because most are modifiable, in contrast to other risk factors such as age and genetics. The main findings in our studies imply that elevated plasma tHcy concentration in elderly patients with... (More)
Many studies have reported higher total plasma homocysteine (tHcy) in elderly patients with mental illness than in control subjects. There are many different determinants of plasma tHcy concentration, including age, cobalamin/folate status, renal function and the presence of vascular disease. The presence of vascular disease may contribute to cognitive impairment. We have investigated elderly patients with regard to plasma tHcy and the presence of vascular disease. Clarification of the role of vascular risk factors in mental illness is important because most are modifiable, in contrast to other risk factors such as age and genetics. The main findings in our studies imply that elevated plasma tHcy concentration in elderly patients with mental illness is mainly associated with the presence of vascular disease and is not related to the specific psychogeriatric diagnosis. Furthermore, it seems possible that the control of conventional vascular risk factors could be guided by the level of plasma tHcy, serum cystatin C, and serum N-terminal pro-brain natriuretic peptide. Patients with an elevation of any of these parameters could be selected for a lower target level of vascular risk factors such as blood pressure cholesterol etc. than conventional target levels. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cognition Disorders: blood, Cognition Disorders: complications, Homocysteine: blood, Mental Disorders: blood, Vascular Diseases: etiology, Mental Disorders: complications, Vascular Diseases: blood, Biological Markers: blood, Alzheimer Disease: blood, Alzheimer Disease: complications
in
Läkartidningen
volume
105
issue
38
pages
2576 - 2578
publisher
Sveriges Läkarförbund
external identifiers
  • pmid:18846861
  • scopus:53549118288
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
1745850e-2ed8-497e-b0d1-1ef839697cc8 (old id 1262328)
alternative location
http://ltarkiv.lakartidningen.se/artNo35562
http://www.ncbi.nlm.nih.gov/pubmed/18846861?dopt=Abstract
date added to LUP
2008-11-05 14:05:47
date last changed
2017-01-01 07:43:48
@article{1745850e-2ed8-497e-b0d1-1ef839697cc8,
  abstract     = {Many studies have reported higher total plasma homocysteine (tHcy) in elderly patients with mental illness than in control subjects. There are many different determinants of plasma tHcy concentration, including age, cobalamin/folate status, renal function and the presence of vascular disease. The presence of vascular disease may contribute to cognitive impairment. We have investigated elderly patients with regard to plasma tHcy and the presence of vascular disease. Clarification of the role of vascular risk factors in mental illness is important because most are modifiable, in contrast to other risk factors such as age and genetics. The main findings in our studies imply that elevated plasma tHcy concentration in elderly patients with mental illness is mainly associated with the presence of vascular disease and is not related to the specific psychogeriatric diagnosis. Furthermore, it seems possible that the control of conventional vascular risk factors could be guided by the level of plasma tHcy, serum cystatin C, and serum N-terminal pro-brain natriuretic peptide. Patients with an elevation of any of these parameters could be selected for a lower target level of vascular risk factors such as blood pressure cholesterol etc. than conventional target levels.},
  author       = {Hultberg, Björn and Nilsson, Anna-Karin and Gustafson, Lars},
  issn         = {0023-7205},
  keyword      = {Cognition Disorders: blood,Cognition Disorders: complications,Homocysteine: blood,Mental Disorders: blood,Vascular Diseases: etiology,Mental Disorders: complications,Vascular Diseases: blood,Biological Markers: blood,Alzheimer Disease: blood,Alzheimer Disease: complications},
  language     = {swe},
  number       = {38},
  pages        = {2576--2578},
  publisher    = {Sveriges Läkarförbund},
  series       = {Läkartidningen},
  title        = {Homocystein--markör för kärlsjukdom hos aldre med psykisk sjukdom.},
  volume       = {105},
  year         = {2008},
}