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C-reactive protein: vascular risk marker in elderly patients with mental illness.

Nilsson, Anna-Karin LU ; Gustafson, Lars LU and Hultberg, Björn LU (2008) In Dementia and Geriatric Cognitive Disorders 26(3). p.251-256
Abstract
BACKGROUND: There is increasing evidence that vascular disease contributes to cognitive impairment and dementia. Clarification of the role of vascular risk factors in dementia is important because most are modifiable, in contrast to other risk factors such as age and genetics. METHODS: In 428 patients with mental illness we have investigated the relation of vascular disease to diagnoses, and a biochemical parameter, C-reactive protein (CRP), which is associated with inflammation and vascular disease. RESULTS: Patients with vascular disease showed higher CRP levels than patients without vascular disease. Furthermore, patients with Alzheimer's disease showed lower CRP levels than patients with vascular dementia, mild cognitive impairment or... (More)
BACKGROUND: There is increasing evidence that vascular disease contributes to cognitive impairment and dementia. Clarification of the role of vascular risk factors in dementia is important because most are modifiable, in contrast to other risk factors such as age and genetics. METHODS: In 428 patients with mental illness we have investigated the relation of vascular disease to diagnoses, and a biochemical parameter, C-reactive protein (CRP), which is associated with inflammation and vascular disease. RESULTS: Patients with vascular disease showed higher CRP levels than patients without vascular disease. Furthermore, patients with Alzheimer's disease showed lower CRP levels than patients with vascular dementia, mild cognitive impairment or depression. There is no obvious reason for this finding, since it could not be attributed to drug treatment. CONCLUSION: The findings indicate that the control of conventional vascular risk factors and therapy could be guided by the level of CRP. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dementia and Geriatric Cognitive Disorders
volume
26
issue
3
pages
251 - 256
publisher
Karger
external identifiers
  • wos:000259876400010
  • pmid:18841009
  • scopus:54749092190
ISSN
1420-8008
DOI
10.1159/000160957
language
English
LU publication?
yes
id
8572be46-1c92-4162-ad6a-9c12d7ac08e2 (old id 1262440)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18841009?dopt=Abstract
date added to LUP
2008-11-05 14:29:25
date last changed
2017-01-01 07:34:06
@article{8572be46-1c92-4162-ad6a-9c12d7ac08e2,
  abstract     = {BACKGROUND: There is increasing evidence that vascular disease contributes to cognitive impairment and dementia. Clarification of the role of vascular risk factors in dementia is important because most are modifiable, in contrast to other risk factors such as age and genetics. METHODS: In 428 patients with mental illness we have investigated the relation of vascular disease to diagnoses, and a biochemical parameter, C-reactive protein (CRP), which is associated with inflammation and vascular disease. RESULTS: Patients with vascular disease showed higher CRP levels than patients without vascular disease. Furthermore, patients with Alzheimer's disease showed lower CRP levels than patients with vascular dementia, mild cognitive impairment or depression. There is no obvious reason for this finding, since it could not be attributed to drug treatment. CONCLUSION: The findings indicate that the control of conventional vascular risk factors and therapy could be guided by the level of CRP.},
  author       = {Nilsson, Anna-Karin and Gustafson, Lars and Hultberg, Björn},
  issn         = {1420-8008},
  language     = {eng},
  number       = {3},
  pages        = {251--256},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {C-reactive protein: vascular risk marker in elderly patients with mental illness.},
  url          = {http://dx.doi.org/10.1159/000160957},
  volume       = {26},
  year         = {2008},
}