T-cell recruitment to the intestinal mucosa.
(2008) In Trends in Immunology Oct 4.. p.514-522- Abstract
- The intestinal epithelium and underlying lamina propria contains large numbers of T cells that play an important role in maintaining intestinal homeostasis and defense against intestinal pathogens. Recent years have seen several significant advances in our understanding of the mechanisms regulating T-cell localization to the intestinal mucosa. For instance, we now know that the small intestine 'imprints' gut homing properties on T cells by inducing the expression of specific integrins and chemokine receptors. Further studies have identified distinct subsets of intestinal dendritic cells that use retinoic acid to generate both gut-tropic and regulatory T cells. As our understanding of the mechanisms regulating the generation of gut tropic... (More)
- The intestinal epithelium and underlying lamina propria contains large numbers of T cells that play an important role in maintaining intestinal homeostasis and defense against intestinal pathogens. Recent years have seen several significant advances in our understanding of the mechanisms regulating T-cell localization to the intestinal mucosa. For instance, we now know that the small intestine 'imprints' gut homing properties on T cells by inducing the expression of specific integrins and chemokine receptors. Further studies have identified distinct subsets of intestinal dendritic cells that use retinoic acid to generate both gut-tropic and regulatory T cells. As our understanding of the mechanisms regulating the generation of gut tropic T-cell populations evolves, the possibility of targeting these processes for mucosal vaccine development and treatment of intestinal immune pathology become more apparent. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1262560
- author
- Agace, William LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Immunology
- volume
- Oct 4.
- pages
- 514 - 522
- publisher
- Elsevier
- external identifiers
-
- wos:000261044900003
- pmid:18838302
- scopus:53849098346
- ISSN
- 1471-4981
- DOI
- 10.1016/j.it.2008.08.003
- language
- English
- LU publication?
- yes
- id
- 4e7fb4e4-2425-4059-b2a5-1813aa400d49 (old id 1262560)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18838302?dopt=Abstract
- date added to LUP
- 2016-04-04 08:06:37
- date last changed
- 2022-02-28 04:29:01
@article{4e7fb4e4-2425-4059-b2a5-1813aa400d49,
abstract = {{The intestinal epithelium and underlying lamina propria contains large numbers of T cells that play an important role in maintaining intestinal homeostasis and defense against intestinal pathogens. Recent years have seen several significant advances in our understanding of the mechanisms regulating T-cell localization to the intestinal mucosa. For instance, we now know that the small intestine 'imprints' gut homing properties on T cells by inducing the expression of specific integrins and chemokine receptors. Further studies have identified distinct subsets of intestinal dendritic cells that use retinoic acid to generate both gut-tropic and regulatory T cells. As our understanding of the mechanisms regulating the generation of gut tropic T-cell populations evolves, the possibility of targeting these processes for mucosal vaccine development and treatment of intestinal immune pathology become more apparent.}},
author = {{Agace, William}},
issn = {{1471-4981}},
language = {{eng}},
pages = {{514--522}},
publisher = {{Elsevier}},
series = {{Trends in Immunology}},
title = {{T-cell recruitment to the intestinal mucosa.}},
url = {{http://dx.doi.org/10.1016/j.it.2008.08.003}},
doi = {{10.1016/j.it.2008.08.003}},
volume = {{Oct 4.}},
year = {{2008}},
}