Advanced

CK5/6 in effusions: no difference between mesothelioma and pulmonary and nonpulmonary adenocarcinoma.

Dejmek, Annika LU (2008) In Acta Cytologica 52(5). p.579-583
Abstract
OBJECTIVE: To test the performance of CK5/6 for the differentiation between mesothelioma, adenocarcinoma and benign mesothelia/proliferations in effusion cytology. STUDY DESIGN: CKS/6 immunocytochemistry was applied to ethanol-fixed cytospin preparations from 74 benign and malignant effusions. RESULTS: Reactivity was seen in 7 of 8 mesotheliomas and in 9 of 11 benign mesothelial proliferations but also in 11 of l7 pulmonary adenocarcinomas and in 12 of 31 adenocarcinomas of nonpulmonary origin. Reactivity was also found in 3 of 5 non-small cell lung carcinomas and 1 of 1 squamous carcinoma. CONCLUSION: CK5/6 reactivity was found in a considerable proportion of metastatic adenocarcinomas of pulmonary and nonpulmonary origin. The high... (More)
OBJECTIVE: To test the performance of CK5/6 for the differentiation between mesothelioma, adenocarcinoma and benign mesothelia/proliferations in effusion cytology. STUDY DESIGN: CKS/6 immunocytochemistry was applied to ethanol-fixed cytospin preparations from 74 benign and malignant effusions. RESULTS: Reactivity was seen in 7 of 8 mesotheliomas and in 9 of 11 benign mesothelial proliferations but also in 11 of l7 pulmonary adenocarcinomas and in 12 of 31 adenocarcinomas of nonpulmonary origin. Reactivity was also found in 3 of 5 non-small cell lung carcinomas and 1 of 1 squamous carcinoma. CONCLUSION: CK5/6 reactivity was found in a considerable proportion of metastatic adenocarcinomas of pulmonary and nonpulmonary origin. The high reactivity rate in pulmonary adenocarcinomas disagrees with the results obtained with histologic sections from solid tumor tissue, and CK5/6 seems to be of very limited value as an additional marker in effusion cytology. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Cytologica
volume
52
issue
5
pages
579 - 583
publisher
Science Printers and Publishers
external identifiers
  • WOS:000259506700011
  • PMID:18833821
  • Scopus:52249096137
ISSN
0001-5547
language
English
LU publication?
yes
id
ede67aef-5635-4085-be5b-1618cda2949f (old id 1262586)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18833821?dopt=Abstract
date added to LUP
2008-11-05 14:32:50
date last changed
2017-01-01 07:52:14
@article{ede67aef-5635-4085-be5b-1618cda2949f,
  abstract     = {OBJECTIVE: To test the performance of CK5/6 for the differentiation between mesothelioma, adenocarcinoma and benign mesothelia/proliferations in effusion cytology. STUDY DESIGN: CKS/6 immunocytochemistry was applied to ethanol-fixed cytospin preparations from 74 benign and malignant effusions. RESULTS: Reactivity was seen in 7 of 8 mesotheliomas and in 9 of 11 benign mesothelial proliferations but also in 11 of l7 pulmonary adenocarcinomas and in 12 of 31 adenocarcinomas of nonpulmonary origin. Reactivity was also found in 3 of 5 non-small cell lung carcinomas and 1 of 1 squamous carcinoma. CONCLUSION: CK5/6 reactivity was found in a considerable proportion of metastatic adenocarcinomas of pulmonary and nonpulmonary origin. The high reactivity rate in pulmonary adenocarcinomas disagrees with the results obtained with histologic sections from solid tumor tissue, and CK5/6 seems to be of very limited value as an additional marker in effusion cytology.},
  author       = {Dejmek, Annika},
  issn         = {0001-5547},
  language     = {eng},
  number       = {5},
  pages        = {579--583},
  publisher    = {Science Printers and Publishers},
  series       = {Acta Cytologica},
  title        = {CK5/6 in effusions: no difference between mesothelioma and pulmonary and nonpulmonary adenocarcinoma.},
  volume       = {52},
  year         = {2008},
}