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Effects of recombinant human activated protein C on the coagulation system: a study with rotational thromboelastometry.

Nilsson, C U; Hellkvist, P D and Engström, Martin LU (2008) In Acta Anaesthesiologica Scandinavica 52(9). p.1246-1249
Abstract
BACKGROUND: Recombinant human activated protein C (rhAPC) is an anticoagulant that can be used for treatment of patients with severe sepsis. The use of rhAPC is accompanied by an increased risk of severe bleeding. Rotational thromboelastometry is a method for measuring the status of the coagulation. The aim of the study was to investigate whether rotational thromboelastometry could be used for monitoring the effects of rhAPC on the coagulation. METHODS: Whole blood was mixed in vitro with concentrations of rhAPC ranging from 0 to 75 ng/ml and analysed with rotational thromboelastometry. RESULTS: The parameter Coagulation Time was significantly prolonged by increasing the concentrations of rhAPC (P=0.002). Other parameters were not... (More)
BACKGROUND: Recombinant human activated protein C (rhAPC) is an anticoagulant that can be used for treatment of patients with severe sepsis. The use of rhAPC is accompanied by an increased risk of severe bleeding. Rotational thromboelastometry is a method for measuring the status of the coagulation. The aim of the study was to investigate whether rotational thromboelastometry could be used for monitoring the effects of rhAPC on the coagulation. METHODS: Whole blood was mixed in vitro with concentrations of rhAPC ranging from 0 to 75 ng/ml and analysed with rotational thromboelastometry. RESULTS: The parameter Coagulation Time was significantly prolonged by increasing the concentrations of rhAPC (P=0.002). Other parameters were not significantly affected. CONCLUSION: rhAPC dose dependently affects the early humoral parts of the coagulation, while platelet function and fibrinogen to fibrin conversion seem virtually unaffected. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Acta Anaesthesiologica Scandinavica
volume
52
issue
9
pages
1246 - 1249
publisher
Wiley-Blackwell
external identifiers
  • wos:000259215600010
  • pmid:18823464
  • scopus:51749118498
ISSN
0001-5172
DOI
10.1111/j.1399-6576.2008.01735.x
language
English
LU publication?
yes
id
d2034616-c67f-4d5b-9726-86fa43e4724c (old id 1262729)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18823464?dopt=Abstract
date added to LUP
2008-11-06 12:02:56
date last changed
2017-01-01 05:01:15
@article{d2034616-c67f-4d5b-9726-86fa43e4724c,
  abstract     = {BACKGROUND: Recombinant human activated protein C (rhAPC) is an anticoagulant that can be used for treatment of patients with severe sepsis. The use of rhAPC is accompanied by an increased risk of severe bleeding. Rotational thromboelastometry is a method for measuring the status of the coagulation. The aim of the study was to investigate whether rotational thromboelastometry could be used for monitoring the effects of rhAPC on the coagulation. METHODS: Whole blood was mixed in vitro with concentrations of rhAPC ranging from 0 to 75 ng/ml and analysed with rotational thromboelastometry. RESULTS: The parameter Coagulation Time was significantly prolonged by increasing the concentrations of rhAPC (P=0.002). Other parameters were not significantly affected. CONCLUSION: rhAPC dose dependently affects the early humoral parts of the coagulation, while platelet function and fibrinogen to fibrin conversion seem virtually unaffected.},
  author       = {Nilsson, C U and Hellkvist, P D and Engström, Martin},
  issn         = {0001-5172},
  language     = {eng},
  number       = {9},
  pages        = {1246--1249},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Anaesthesiologica Scandinavica},
  title        = {Effects of recombinant human activated protein C on the coagulation system: a study with rotational thromboelastometry.},
  url          = {http://dx.doi.org/10.1111/j.1399-6576.2008.01735.x},
  volume       = {52},
  year         = {2008},
}