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Use of calcium channel blockers and beta blockers as antihypertensives in relation to mortality in type 2 diabetes patients: a population-based observational study.

Lindberg, Gunnar LU ; Olsson, J and Melander, Arne LU (2000) In Pharmacoepidemiology and Drug Safety 9(2). p.127-131
Abstract
OBJECTIVES: In previous trials, patients with type 2 diabetes using calcium channel blockers (CCB) have suffered a less favourable outcome when compared with patients on other treatments. The present study was designed to compare mortality in type 2 diabetes patients using either CCB or beta blockers (BB) as antihypertensive agents. DESIGN: Retrospective observational study. Patients were followed from the first day they were on either of the study drugs until 31 December 1996, or until death. SETTINGS: Two Swedish municipalities. SUBJECTS: All patients with type 2 diabetes who were using a CCB or a BB as an antihypertensive agent during 1984-1994. MAIN OUTCOME MEASURES: Adjusted odds ratio for overall and cause-specific mortality in CCB... (More)
OBJECTIVES: In previous trials, patients with type 2 diabetes using calcium channel blockers (CCB) have suffered a less favourable outcome when compared with patients on other treatments. The present study was designed to compare mortality in type 2 diabetes patients using either CCB or beta blockers (BB) as antihypertensive agents. DESIGN: Retrospective observational study. Patients were followed from the first day they were on either of the study drugs until 31 December 1996, or until death. SETTINGS: Two Swedish municipalities. SUBJECTS: All patients with type 2 diabetes who were using a CCB or a BB as an antihypertensive agent during 1984-1994. MAIN OUTCOME MEASURES: Adjusted odds ratio for overall and cause-specific mortality in CCB users versus BB users. RESULTS: Ninety-six users of CCB and 270 users of BB were included. The odds ratio for overall mortality, adjusted for age, sex, inclusion year and municipality was 1.78 (95% CI 1.17-2.71) in CCB users versus BB users. Corresponding odds ratios for mortality from IHD, stroke, cancer and other causes were 1.11, 2.41, 1.63 and 2.61, respectively. However, among those, only mortality due to other causes was significantly elevated. CONCLUSIONS: This study adds support to the possibility of an adverse outcome in patients with diabetes using a CCB. An agent interfering with various cell functions such as calcium ion channels may also interfere with many pathways, increasing mortality. Therefore, a relation between blockade of calcium ion channels and miscellaneous causes of death should not be discarded. Our findings warrant careful examinations in other population-based studies. Copyright (c) 2000 John Wiley & Sons, Ltd. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pharmacoepidemiology and Drug Safety
volume
9
issue
2
pages
127 - 131
publisher
John Wiley & Sons
external identifiers
  • pmid:19025812
  • scopus:0034065037
ISSN
1053-8569
DOI
10.1002/(SICI)1099-1557(200003/04)9:2<127::AID-PDS475>3.0.CO;2-Z
language
English
LU publication?
yes
id
069a3f77-0f37-4a25-9b7a-18d9230865a1 (old id 1271194)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19025812?dopt=Abstract
date added to LUP
2008-12-03 12:12:46
date last changed
2017-01-01 07:32:21
@article{069a3f77-0f37-4a25-9b7a-18d9230865a1,
  abstract     = {OBJECTIVES: In previous trials, patients with type 2 diabetes using calcium channel blockers (CCB) have suffered a less favourable outcome when compared with patients on other treatments. The present study was designed to compare mortality in type 2 diabetes patients using either CCB or beta blockers (BB) as antihypertensive agents. DESIGN: Retrospective observational study. Patients were followed from the first day they were on either of the study drugs until 31 December 1996, or until death. SETTINGS: Two Swedish municipalities. SUBJECTS: All patients with type 2 diabetes who were using a CCB or a BB as an antihypertensive agent during 1984-1994. MAIN OUTCOME MEASURES: Adjusted odds ratio for overall and cause-specific mortality in CCB users versus BB users. RESULTS: Ninety-six users of CCB and 270 users of BB were included. The odds ratio for overall mortality, adjusted for age, sex, inclusion year and municipality was 1.78 (95% CI 1.17-2.71) in CCB users versus BB users. Corresponding odds ratios for mortality from IHD, stroke, cancer and other causes were 1.11, 2.41, 1.63 and 2.61, respectively. However, among those, only mortality due to other causes was significantly elevated. CONCLUSIONS: This study adds support to the possibility of an adverse outcome in patients with diabetes using a CCB. An agent interfering with various cell functions such as calcium ion channels may also interfere with many pathways, increasing mortality. Therefore, a relation between blockade of calcium ion channels and miscellaneous causes of death should not be discarded. Our findings warrant careful examinations in other population-based studies. Copyright (c) 2000 John Wiley &amp; Sons, Ltd.},
  author       = {Lindberg, Gunnar and Olsson, J and Melander, Arne},
  issn         = {1053-8569},
  language     = {eng},
  number       = {2},
  pages        = {127--131},
  publisher    = {John Wiley & Sons},
  series       = {Pharmacoepidemiology and Drug Safety},
  title        = {Use of calcium channel blockers and beta blockers as antihypertensives in relation to mortality in type 2 diabetes patients: a population-based observational study.},
  url          = {http://dx.doi.org/10.1002/(SICI)1099-1557(200003/04)9:2<127::AID-PDS475>3.0.CO;2-Z},
  volume       = {9},
  year         = {2000},
}