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Stuttering and the basal ganglia circuits: a critical review of possible relations.

Alm, Per A LU (2004) In Journal of Communication Disorders 37(4). p.325-369
Abstract
The possible relation between stuttering and the basal ganglia is discussed. Important clues to the pathophysiology of stuttering are given by conditions known to alleviate dysfluency, like the rhythm effect, chorus speech, and singing. Information regarding pharmacologic trials, lesion studies, brain imaging, genetics, and developmental changes of the nervous system is reviewed. The symptoms of stuttering are compared with basal ganglia motor disorders like Parkinson’s disease and dystonia. It is proposed that the basal ganglia-thalamocortical motor circuits through the putamen are likely to play a key role in stuttering. The core dysfunction in stuttering is suggested to be impaired ability of the basal ganglia to produce timing cues for... (More)
The possible relation between stuttering and the basal ganglia is discussed. Important clues to the pathophysiology of stuttering are given by conditions known to alleviate dysfluency, like the rhythm effect, chorus speech, and singing. Information regarding pharmacologic trials, lesion studies, brain imaging, genetics, and developmental changes of the nervous system is reviewed. The symptoms of stuttering are compared with basal ganglia motor disorders like Parkinson’s disease and dystonia. It is proposed that the basal ganglia-thalamocortical motor circuits through the putamen are likely to play a key role in stuttering. The core dysfunction in stuttering is suggested to be impaired ability of the basal ganglia to produce timing cues for the initiation of the next motor segment in speech. Similarities between stuttering and dystonia are indicated, and possible relations to the dopamine system are discussed, as well as the interaction between the cerebral cortex and the basal ganglia. Behavioral and pharmacologic information suggests the existence of subtypes of stuttering. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Basal ganglia, Cluttering, Dopamine, Dystonia, Stuttering
in
Journal of Communication Disorders
volume
37
issue
4
pages
325 - 369
publisher
Elsevier
external identifiers
  • wos:000221973900003
  • scopus:2542500566
ISSN
1873-7994
DOI
10.1016/j.jcomdis.2004.03.001
language
English
LU publication?
yes
id
32f42404-06c6-4c42-bf8a-a6126354ef2d (old id 127133)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15159193
date added to LUP
2007-06-21 14:05:12
date last changed
2017-12-10 03:53:25
@article{32f42404-06c6-4c42-bf8a-a6126354ef2d,
  abstract     = {The possible relation between stuttering and the basal ganglia is discussed. Important clues to the pathophysiology of stuttering are given by conditions known to alleviate dysfluency, like the rhythm effect, chorus speech, and singing. Information regarding pharmacologic trials, lesion studies, brain imaging, genetics, and developmental changes of the nervous system is reviewed. The symptoms of stuttering are compared with basal ganglia motor disorders like Parkinson’s disease and dystonia. It is proposed that the basal ganglia-thalamocortical motor circuits through the putamen are likely to play a key role in stuttering. The core dysfunction in stuttering is suggested to be impaired ability of the basal ganglia to produce timing cues for the initiation of the next motor segment in speech. Similarities between stuttering and dystonia are indicated, and possible relations to the dopamine system are discussed, as well as the interaction between the cerebral cortex and the basal ganglia. Behavioral and pharmacologic information suggests the existence of subtypes of stuttering.},
  author       = {Alm, Per A},
  issn         = {1873-7994},
  keyword      = {Basal ganglia,Cluttering,Dopamine,Dystonia,Stuttering},
  language     = {eng},
  number       = {4},
  pages        = {325--369},
  publisher    = {Elsevier},
  series       = {Journal of Communication Disorders},
  title        = {Stuttering and the basal ganglia circuits: a critical review of possible relations.},
  url          = {http://dx.doi.org/10.1016/j.jcomdis.2004.03.001},
  volume       = {37},
  year         = {2004},
}