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L-DOPA-induced dyskinesia: cellular mechanisms and approaches to treatment.

Cenci Nilsson, Angela LU (2007) In Parkinsonism & Related Disorders 13 Suppl 3. p.263-267
Abstract
L-DOPA-induced dyskinesia (LID) is a common complication of the treatment of Parkinson's disease, and its precise mechanisms have long remained unknown. Rodent models of LID provide a tool to dissect the impact of specific factors on the development and expression of dyskinetic movements. This short review will summarize recent findings from rodent studies that have consolidated and considerably expanded our mechanistic understanding of LID. Based on the experimental findings, the review will propose a chart of possible treatment options acting on different pathophysiological levels.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Parkinsonism & Related Disorders
volume
13 Suppl 3
pages
263 - 267
publisher
Elsevier
external identifiers
  • wos:000258136100014
  • pmid:18267248
  • scopus:38949195712
ISSN
1873-5126
DOI
10.1016/S1353-8020(08)70014-2
language
English
LU publication?
yes
id
0bb55eb7-4217-4920-bde5-5d8de4c0170d (old id 1271393)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18267248?dopt=Abstract
date added to LUP
2008-12-04 15:41:52
date last changed
2017-07-30 04:49:46
@article{0bb55eb7-4217-4920-bde5-5d8de4c0170d,
  abstract     = {L-DOPA-induced dyskinesia (LID) is a common complication of the treatment of Parkinson's disease, and its precise mechanisms have long remained unknown. Rodent models of LID provide a tool to dissect the impact of specific factors on the development and expression of dyskinetic movements. This short review will summarize recent findings from rodent studies that have consolidated and considerably expanded our mechanistic understanding of LID. Based on the experimental findings, the review will propose a chart of possible treatment options acting on different pathophysiological levels.},
  author       = {Cenci Nilsson, Angela},
  issn         = {1873-5126},
  language     = {eng},
  pages        = {263--267},
  publisher    = {Elsevier},
  series       = {Parkinsonism & Related Disorders},
  title        = {L-DOPA-induced dyskinesia: cellular mechanisms and approaches to treatment.},
  url          = {http://dx.doi.org/10.1016/S1353-8020(08)70014-2},
  volume       = {13 Suppl 3},
  year         = {2007},
}