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Incidence of diabetes in middle-aged men is related to sleep disturbances.

Nilsson, Peter LU ; Rööst, Mattias LU ; Engström, Gunnar LU ; Hedblad, Bo LU and Berglund, Göran LU (2004) In Diabetes Care 27(10). p.2464-2469
Abstract
OBJECTIVE—Sleep deprivation in healthy men has been experimentally found to result in disturbances in glucose metabolism and in sympathovagal imbalance. The aim of the present study was to investigate whether sleep disturbances and elevated resting heart rate are associated with increased risk of developing diabetes.



RESEARCH DESIGN AND METHODS—A group of 6,599 initially healthy, nondiabetic men aged 44.5 ± 4.0 years took part in a prospective, population-based study in Malmö, Sweden. The incidence of diabetes during a mean follow-up of 14.8 ± 2.4 years was examined in relation to self-reported difficulties in falling asleep and resting heart rate at baseline. Diabetes was assessed at follow-up in all subjects by... (More)
OBJECTIVE—Sleep deprivation in healthy men has been experimentally found to result in disturbances in glucose metabolism and in sympathovagal imbalance. The aim of the present study was to investigate whether sleep disturbances and elevated resting heart rate are associated with increased risk of developing diabetes.



RESEARCH DESIGN AND METHODS—A group of 6,599 initially healthy, nondiabetic men aged 44.5 ± 4.0 years took part in a prospective, population-based study in Malmö, Sweden. The incidence of diabetes during a mean follow-up of 14.8 ± 2.4 years was examined in relation to self-reported difficulties in falling asleep and resting heart rate at baseline. Diabetes was assessed at follow-up in all subjects by questionnaire and in a subgroup of 1,551 men by blood glucose measurement.



RESULTS—A total of 615 (9.3%) subjects reported either difficulties in falling asleep or regular use of hypnotics (seen as markers of sleep disturbances), and 158 (2.4%) subjects reported both of these. Altogether, 281 (4.3%) of the men developed diabetes during the follow-up period. Logistic regression models showed difficulties in falling asleep or regular use of hypnotics (odds ratio [OR] 1.52 [95% CI 1.05–2.20]) and resting heart rate (OR per 10 bpm 1.13 [0.99–1.30]) to be associated with development of diabetes when full adjustments were made for baseline age, biological risk factors, lifestyle, family history of diabetes, and social class.



CONCLUSIONS—The results suggest that sleep disturbances and, possibly, elevated resting heart rate, in middle-aged men, are associated with an increased risk of diabetes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
27
issue
10
pages
2464 - 2469
publisher
American Diabetes Association
external identifiers
  • pmid:15451917
  • wos:000224115700028
  • scopus:4644371124
ISSN
1935-5548
DOI
10.2337/diacare.27.10.2464
language
English
LU publication?
yes
id
f2789415-3d67-4e89-a8c5-24de607442b4 (old id 127143)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15451917&dopt=Abstract
date added to LUP
2007-07-27 10:38:44
date last changed
2017-12-03 03:41:28
@article{f2789415-3d67-4e89-a8c5-24de607442b4,
  abstract     = {OBJECTIVE—Sleep deprivation in healthy men has been experimentally found to result in disturbances in glucose metabolism and in sympathovagal imbalance. The aim of the present study was to investigate whether sleep disturbances and elevated resting heart rate are associated with increased risk of developing diabetes.<br/><br>
<br/><br>
RESEARCH DESIGN AND METHODS—A group of 6,599 initially healthy, nondiabetic men aged 44.5 ± 4.0 years took part in a prospective, population-based study in Malmö, Sweden. The incidence of diabetes during a mean follow-up of 14.8 ± 2.4 years was examined in relation to self-reported difficulties in falling asleep and resting heart rate at baseline. Diabetes was assessed at follow-up in all subjects by questionnaire and in a subgroup of 1,551 men by blood glucose measurement.<br/><br>
<br/><br>
RESULTS—A total of 615 (9.3%) subjects reported either difficulties in falling asleep or regular use of hypnotics (seen as markers of sleep disturbances), and 158 (2.4%) subjects reported both of these. Altogether, 281 (4.3%) of the men developed diabetes during the follow-up period. Logistic regression models showed difficulties in falling asleep or regular use of hypnotics (odds ratio [OR] 1.52 [95% CI 1.05–2.20]) and resting heart rate (OR per 10 bpm 1.13 [0.99–1.30]) to be associated with development of diabetes when full adjustments were made for baseline age, biological risk factors, lifestyle, family history of diabetes, and social class.<br/><br>
<br/><br>
CONCLUSIONS—The results suggest that sleep disturbances and, possibly, elevated resting heart rate, in middle-aged men, are associated with an increased risk of diabetes.},
  author       = {Nilsson, Peter and Rööst, Mattias and Engström, Gunnar and Hedblad, Bo and Berglund, Göran},
  issn         = {1935-5548},
  language     = {eng},
  number       = {10},
  pages        = {2464--2469},
  publisher    = {American Diabetes Association},
  series       = {Diabetes Care},
  title        = {Incidence of diabetes in middle-aged men is related to sleep disturbances.},
  url          = {http://dx.doi.org/10.2337/diacare.27.10.2464},
  volume       = {27},
  year         = {2004},
}