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Topical negative pressure effects on coronary blood flow in a sternal wound model.

Lindstedt Ingemansson, Sandra LU ; Malmsjö, Malin LU ; Gesslein, Bodil LU and Ingemansson, Richard LU (2008) In International Wound Journal 5(4). p.503-509
Abstract
Several studies have suggested that mediastinitis is a strong predictor for poor long-term survival after coronary artery bypass surgery (CABG). In those studies, several conventional wound-healing techniques were used. Previously, we have shown no difference in long-term survival between CABG patients with topical negative pressure (TNP)-treated mediastinitis and CABG patients without mediastinitis. The present study was designed to elucidate if TNP, applied over the myocardium, resulted in an increase of the total amount of coronary blood flow. Six pigs underwent median sternotomy. The coronary blood flow was measured, before and after the application of TNP (-50 mmHg), using coronary electromagnetic flow meter probes. Analyses were... (More)
Several studies have suggested that mediastinitis is a strong predictor for poor long-term survival after coronary artery bypass surgery (CABG). In those studies, several conventional wound-healing techniques were used. Previously, we have shown no difference in long-term survival between CABG patients with topical negative pressure (TNP)-treated mediastinitis and CABG patients without mediastinitis. The present study was designed to elucidate if TNP, applied over the myocardium, resulted in an increase of the total amount of coronary blood flow. Six pigs underwent median sternotomy. The coronary blood flow was measured, before and after the application of TNP (-50 mmHg), using coronary electromagnetic flow meter probes. Analyses were performed before left anterior descending artery (LAD) occlusion (normal myocardium) and after 20 minutes of LAD occlusion (ischaemic myocardium). Normal myocardium: 171.3 +/- 14.5 ml/minute before to 206.3 +/- 17.6 ml/minute after TNP application, P < 0.05. Ischaemic myocardium: 133.7 +/- 18.4 ml/minute before to 183.2 +/- 18.9 ml/minute after TNP application, P < 0.05. TNP of -50 mmHg applied over the LAD region induced a significant increase in the total coronary blood flow in both normal and ischaemic myocardium. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Wound Journal
volume
5
issue
4
pages
503 - 509
publisher
Wiley-Blackwell
external identifiers
  • wos:000207844200004
  • pmid:19006573
  • scopus:54249144755
ISSN
1742-481X
DOI
10.1111/j.1742-481X.2008.00429.x
language
English
LU publication?
yes
id
4291c88a-c461-4d39-813e-10fa87211219 (old id 1271494)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19006573?dopt=Abstract
date added to LUP
2008-12-04 13:59:36
date last changed
2017-01-01 07:35:43
@article{4291c88a-c461-4d39-813e-10fa87211219,
  abstract     = {Several studies have suggested that mediastinitis is a strong predictor for poor long-term survival after coronary artery bypass surgery (CABG). In those studies, several conventional wound-healing techniques were used. Previously, we have shown no difference in long-term survival between CABG patients with topical negative pressure (TNP)-treated mediastinitis and CABG patients without mediastinitis. The present study was designed to elucidate if TNP, applied over the myocardium, resulted in an increase of the total amount of coronary blood flow. Six pigs underwent median sternotomy. The coronary blood flow was measured, before and after the application of TNP (-50 mmHg), using coronary electromagnetic flow meter probes. Analyses were performed before left anterior descending artery (LAD) occlusion (normal myocardium) and after 20 minutes of LAD occlusion (ischaemic myocardium). Normal myocardium: 171.3 +/- 14.5 ml/minute before to 206.3 +/- 17.6 ml/minute after TNP application, P &lt; 0.05. Ischaemic myocardium: 133.7 +/- 18.4 ml/minute before to 183.2 +/- 18.9 ml/minute after TNP application, P &lt; 0.05. TNP of -50 mmHg applied over the LAD region induced a significant increase in the total coronary blood flow in both normal and ischaemic myocardium.},
  author       = {Lindstedt Ingemansson, Sandra and Malmsjö, Malin and Gesslein, Bodil and Ingemansson, Richard},
  issn         = {1742-481X},
  language     = {eng},
  number       = {4},
  pages        = {503--509},
  publisher    = {Wiley-Blackwell},
  series       = {International Wound Journal},
  title        = {Topical negative pressure effects on coronary blood flow in a sternal wound model.},
  url          = {http://dx.doi.org/10.1111/j.1742-481X.2008.00429.x},
  volume       = {5},
  year         = {2008},
}