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Fresh-frozen Plasma as a Source of Exogenous Insulin-like Growth Factor I in the Extremely Preterm Infant.

Pupp, Ingrid LU ; Engström, Eva; Niklasson, Aimon; Berg, Ann-Cathrine LU ; Fellman, Vineta LU ; Löfqvist, Chatarina; Hellström, Ann LU and Ley, David LU (2009) In Journal of Clinical Endocrinology and Metabolism 94(2). p.477-482
Abstract
Context: Preterm birth is followed by a decrease in circulatory levels of IGF-I and IGF binding protein-3 (IGFBP-3), proteins with important neurogenic and angiogenic properties. Objective: To evaluate effects of intravenous administration of fresh frozen plasma (FFP) from adult donors on circulatory levels of IGF-I and IGFBP-3 in extremely preterm infants. Design, setting and patients: A prospective cohort study performed in twenty extremely preterm infants (mean (SD) gestational age 25.3 (1.3) weeks) with clinical requirement of FFP during the first postnatal week. Sampling was performed before initiation of transfusion, directly after and at 6, 12, 24 and 48h after completed FFP transfusion. Main outcome measures: Concentrations of... (More)
Context: Preterm birth is followed by a decrease in circulatory levels of IGF-I and IGF binding protein-3 (IGFBP-3), proteins with important neurogenic and angiogenic properties. Objective: To evaluate effects of intravenous administration of fresh frozen plasma (FFP) from adult donors on circulatory levels of IGF-I and IGFBP-3 in extremely preterm infants. Design, setting and patients: A prospective cohort study performed in twenty extremely preterm infants (mean (SD) gestational age 25.3 (1.3) weeks) with clinical requirement of FFP during the first postnatal week. Sampling was performed before initiation of transfusion, directly after and at 6, 12, 24 and 48h after completed FFP transfusion. Main outcome measures: Concentrations of IGF-I and IGFBP-3 before and after transfusion of FFP. Results: FFP with a mean (SD) volume of 11 (3.1) ml/kg, was administered at a postnatal age of median (range) 2 (1-7) days. Mean (SD) IGF-I and IGFBP-3 concentrations in administered FFP were 130 (39) and 2840 (615) microg/L, respectively. Immediately after FFP transfusion, mean (SD) concentrations of IGF-I increased by 133% from 11 (6.4) to 25 (9.3) microg/L, p<0.001 and IGFBP-3 by 61% from 815 (451) to 1311 (508) microg/L, p<0.001. Concentrations of IGF-I and IGFBP-3 remained higher at 6 h, p<0.001, p=0.009 and at 12 h, p=0.017, p=0.018, respectively, as compared to concentrations before FFP transfusion. Typical half-life of administrated IGF-I was 3.4 h for a 1 kg infant. Conclusion: Transfusion of FFP to extremely preterm infants during the first postnatal week elevates levels of IGF-I and IGFBP-3. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Endocrinology and Metabolism
volume
94
issue
2
pages
477 - 482
publisher
The Endocrine Society
external identifiers
  • wos:000263072700023
  • pmid:19001522
  • scopus:59749091358
ISSN
1945-7197
DOI
10.1210/jc.2008-1293
language
English
LU publication?
yes
id
a61f8dd3-a2d9-4457-a8e2-4124c40b3785 (old id 1271578)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19001522?dopt=Abstract
date added to LUP
2008-12-04 15:07:05
date last changed
2017-10-01 04:18:19
@article{a61f8dd3-a2d9-4457-a8e2-4124c40b3785,
  abstract     = {Context: Preterm birth is followed by a decrease in circulatory levels of IGF-I and IGF binding protein-3 (IGFBP-3), proteins with important neurogenic and angiogenic properties. Objective: To evaluate effects of intravenous administration of fresh frozen plasma (FFP) from adult donors on circulatory levels of IGF-I and IGFBP-3 in extremely preterm infants. Design, setting and patients: A prospective cohort study performed in twenty extremely preterm infants (mean (SD) gestational age 25.3 (1.3) weeks) with clinical requirement of FFP during the first postnatal week. Sampling was performed before initiation of transfusion, directly after and at 6, 12, 24 and 48h after completed FFP transfusion. Main outcome measures: Concentrations of IGF-I and IGFBP-3 before and after transfusion of FFP. Results: FFP with a mean (SD) volume of 11 (3.1) ml/kg, was administered at a postnatal age of median (range) 2 (1-7) days. Mean (SD) IGF-I and IGFBP-3 concentrations in administered FFP were 130 (39) and 2840 (615) microg/L, respectively. Immediately after FFP transfusion, mean (SD) concentrations of IGF-I increased by 133% from 11 (6.4) to 25 (9.3) microg/L, p&lt;0.001 and IGFBP-3 by 61% from 815 (451) to 1311 (508) microg/L, p&lt;0.001. Concentrations of IGF-I and IGFBP-3 remained higher at 6 h, p&lt;0.001, p=0.009 and at 12 h, p=0.017, p=0.018, respectively, as compared to concentrations before FFP transfusion. Typical half-life of administrated IGF-I was 3.4 h for a 1 kg infant. Conclusion: Transfusion of FFP to extremely preterm infants during the first postnatal week elevates levels of IGF-I and IGFBP-3.},
  author       = {Pupp, Ingrid and Engström, Eva and Niklasson, Aimon and Berg, Ann-Cathrine and Fellman, Vineta and Löfqvist, Chatarina and Hellström, Ann and Ley, David},
  issn         = {1945-7197},
  language     = {eng},
  number       = {2},
  pages        = {477--482},
  publisher    = {The Endocrine Society},
  series       = {Journal of Clinical Endocrinology and Metabolism},
  title        = {Fresh-frozen Plasma as a Source of Exogenous Insulin-like Growth Factor I in the Extremely Preterm Infant.},
  url          = {http://dx.doi.org/10.1210/jc.2008-1293},
  volume       = {94},
  year         = {2009},
}