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Allergen-exposure of Mouse Airways Evokes Remodeling of both Bronchi and Large Pulmonary Vessels.

Rydell-Törmänen, Kristina LU ; Uller, Lena LU ; Persson, Carl LU and Erjefält, Jonas LU (2005) In American Journal of Respiratory and Critical Care Medicine 171(1). p.19-25
Abstract
Remodeling of airway structures is a well-documented feature of allergic airway inflammation. To investigate whether bronchial remodeling is associated with remodeling of adjacent pulmonary vessels, sensitized mice were subjected to repeated ovalbumin inhalations, and bronchi and pulmonary vessels were subjected to histologic analysis. Allergen challenges induced peribronchial as well as perivascular eosinophilia. Remodeling of systemic airway microcirculation, as studied in tracheal whole-mount preparations, revealed an allergen-induced increase in both the diameter and length of the airway microvessels. Immunostaining for alpha-smooth muscle actin disclosed an increase in smooth muscle mass in both bronchi and large pulmonary vessels.... (More)
Remodeling of airway structures is a well-documented feature of allergic airway inflammation. To investigate whether bronchial remodeling is associated with remodeling of adjacent pulmonary vessels, sensitized mice were subjected to repeated ovalbumin inhalations, and bronchi and pulmonary vessels were subjected to histologic analysis. Allergen challenges induced peribronchial as well as perivascular eosinophilia. Remodeling of systemic airway microcirculation, as studied in tracheal whole-mount preparations, revealed an allergen-induced increase in both the diameter and length of the airway microvessels. Immunostaining for alpha-smooth muscle actin disclosed an increase in smooth muscle mass in both bronchi and large pulmonary vessels. Both bronchi and pulmonary vessels also displayed increased expression of procollagen I and procollagen III. Staining for proliferating cell nuclear antigen revealed increased proliferation of bronchial epithelial and smooth muscle cells as well as pulmonary vascular endothelial and smooth muscle cells. We conclude that central features of remodeling that take place in allergen-exposed airways are present also in the pulmonary vessels. The significance of this finding with respect to occurrence in disease, pathophysiologic importance, and involved mechanisms warrants further investigation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
animal model, asthma, vascular remodeling, eosinophils
in
American Journal of Respiratory and Critical Care Medicine
volume
171
issue
1
pages
19 - 25
publisher
Am Thoracic Soc
external identifiers
  • wos:000225984800005
  • pmid:15447945
  • scopus:11144229675
ISSN
1535-4970
DOI
10.1164/rccm.200406-698OC
language
English
LU publication?
yes
id
c9c60018-06e2-4c70-b59c-0ff3ddd211b8 (old id 127177)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15447945&dopt=Abstract
date added to LUP
2007-07-19 10:53:01
date last changed
2017-09-17 04:52:15
@article{c9c60018-06e2-4c70-b59c-0ff3ddd211b8,
  abstract     = {Remodeling of airway structures is a well-documented feature of allergic airway inflammation. To investigate whether bronchial remodeling is associated with remodeling of adjacent pulmonary vessels, sensitized mice were subjected to repeated ovalbumin inhalations, and bronchi and pulmonary vessels were subjected to histologic analysis. Allergen challenges induced peribronchial as well as perivascular eosinophilia. Remodeling of systemic airway microcirculation, as studied in tracheal whole-mount preparations, revealed an allergen-induced increase in both the diameter and length of the airway microvessels. Immunostaining for alpha-smooth muscle actin disclosed an increase in smooth muscle mass in both bronchi and large pulmonary vessels. Both bronchi and pulmonary vessels also displayed increased expression of procollagen I and procollagen III. Staining for proliferating cell nuclear antigen revealed increased proliferation of bronchial epithelial and smooth muscle cells as well as pulmonary vascular endothelial and smooth muscle cells. We conclude that central features of remodeling that take place in allergen-exposed airways are present also in the pulmonary vessels. The significance of this finding with respect to occurrence in disease, pathophysiologic importance, and involved mechanisms warrants further investigation.},
  author       = {Rydell-Törmänen, Kristina and Uller, Lena and Persson, Carl and Erjefält, Jonas},
  issn         = {1535-4970},
  keyword      = {animal model,asthma,vascular remodeling,eosinophils},
  language     = {eng},
  number       = {1},
  pages        = {19--25},
  publisher    = {Am Thoracic Soc},
  series       = {American Journal of Respiratory and Critical Care Medicine},
  title        = {Allergen-exposure of Mouse Airways Evokes Remodeling of both Bronchi and Large Pulmonary Vessels.},
  url          = {http://dx.doi.org/10.1164/rccm.200406-698OC},
  volume       = {171},
  year         = {2005},
}