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Allergen-exposure of Mouse Airways Evokes Remodeling of both Bronchi and Large Pulmonary Vessels.

Rydell-Törmänen, Kristina LU orcid ; Uller, Lena LU ; Persson, Carl LU and Erjefält, Jonas LU (2005) In American Journal of Respiratory and Critical Care Medicine 171(1). p.19-25
Abstract
Remodeling of airway structures is a well-documented feature of allergic airway inflammation. To investigate whether bronchial remodeling is associated with remodeling of adjacent pulmonary vessels, sensitized mice were subjected to repeated ovalbumin inhalations, and bronchi and pulmonary vessels were subjected to histologic analysis. Allergen challenges induced peribronchial as well as perivascular eosinophilia. Remodeling of systemic airway microcirculation, as studied in tracheal whole-mount preparations, revealed an allergen-induced increase in both the diameter and length of the airway microvessels. Immunostaining for alpha-smooth muscle actin disclosed an increase in smooth muscle mass in both bronchi and large pulmonary vessels.... (More)
Remodeling of airway structures is a well-documented feature of allergic airway inflammation. To investigate whether bronchial remodeling is associated with remodeling of adjacent pulmonary vessels, sensitized mice were subjected to repeated ovalbumin inhalations, and bronchi and pulmonary vessels were subjected to histologic analysis. Allergen challenges induced peribronchial as well as perivascular eosinophilia. Remodeling of systemic airway microcirculation, as studied in tracheal whole-mount preparations, revealed an allergen-induced increase in both the diameter and length of the airway microvessels. Immunostaining for alpha-smooth muscle actin disclosed an increase in smooth muscle mass in both bronchi and large pulmonary vessels. Both bronchi and pulmonary vessels also displayed increased expression of procollagen I and procollagen III. Staining for proliferating cell nuclear antigen revealed increased proliferation of bronchial epithelial and smooth muscle cells as well as pulmonary vascular endothelial and smooth muscle cells. We conclude that central features of remodeling that take place in allergen-exposed airways are present also in the pulmonary vessels. The significance of this finding with respect to occurrence in disease, pathophysiologic importance, and involved mechanisms warrants further investigation. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
animal model, asthma, vascular remodeling, eosinophils
in
American Journal of Respiratory and Critical Care Medicine
volume
171
issue
1
pages
19 - 25
publisher
American Thoracic Society
external identifiers
  • wos:000225984800005
  • pmid:15447945
  • scopus:11144229675
  • pmid:15447945
ISSN
1535-4970
DOI
10.1164/rccm.200406-698OC
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Airway Inflammation and Immunology (013212038), Division of Clinical Chemistry and Pharmacology (013250300), Lung Biology (013212002), Neuroendocrine Cell Biology (013212008)
id
c9c60018-06e2-4c70-b59c-0ff3ddd211b8 (old id 127177)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15447945&dopt=Abstract
date added to LUP
2016-04-01 11:55:07
date last changed
2020-11-16 05:41:03
@article{c9c60018-06e2-4c70-b59c-0ff3ddd211b8,
  abstract     = {Remodeling of airway structures is a well-documented feature of allergic airway inflammation. To investigate whether bronchial remodeling is associated with remodeling of adjacent pulmonary vessels, sensitized mice were subjected to repeated ovalbumin inhalations, and bronchi and pulmonary vessels were subjected to histologic analysis. Allergen challenges induced peribronchial as well as perivascular eosinophilia. Remodeling of systemic airway microcirculation, as studied in tracheal whole-mount preparations, revealed an allergen-induced increase in both the diameter and length of the airway microvessels. Immunostaining for alpha-smooth muscle actin disclosed an increase in smooth muscle mass in both bronchi and large pulmonary vessels. Both bronchi and pulmonary vessels also displayed increased expression of procollagen I and procollagen III. Staining for proliferating cell nuclear antigen revealed increased proliferation of bronchial epithelial and smooth muscle cells as well as pulmonary vascular endothelial and smooth muscle cells. We conclude that central features of remodeling that take place in allergen-exposed airways are present also in the pulmonary vessels. The significance of this finding with respect to occurrence in disease, pathophysiologic importance, and involved mechanisms warrants further investigation.},
  author       = {Rydell-Törmänen, Kristina and Uller, Lena and Persson, Carl and Erjefält, Jonas},
  issn         = {1535-4970},
  language     = {eng},
  number       = {1},
  pages        = {19--25},
  publisher    = {American Thoracic Society},
  series       = {American Journal of Respiratory and Critical Care Medicine},
  title        = {Allergen-exposure of Mouse Airways Evokes Remodeling of both Bronchi and Large Pulmonary Vessels.},
  url          = {http://dx.doi.org/10.1164/rccm.200406-698OC},
  doi          = {10.1164/rccm.200406-698OC},
  volume       = {171},
  year         = {2005},
}