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CCL25/CCR9 promotes the induction and function of CD103 on intestinal intraepithelial lymphocytes.

Ericsson, Anna LU ; Svensson Frej, Marcus LU ; Arya, Anu and Agace, William LU (2004) In European Journal of Immunology 34(10). p.2720-2729
Abstract
The integrin CD103 and the chemokine receptor CCR9 are co-expressed on small intestinal CD8+ intraepithelial lymphocytes (IEL), naïve murine CD8+ T cells and by a small population of effector/memory CD8+ T cells, indicating a potential role for CCR9 in regulating CD103 expression and function. Here, we demonstrate that CD103, in contrast to CCR9, is down-regulated on CD8+ T cells following their activation in mesenteric lymph nodes and that effector CD8+ T cells upon initial entry into the small intestinal epithelium are CCR9+CD103-. CD103 was rapidly induced on wild-type CD8+ T cells subsequent to their entry into the small intestinal epithelium, however, CCR9-/- CD8+ T cells exhibited a significant delay in CD103 induction at this site.... (More)
The integrin CD103 and the chemokine receptor CCR9 are co-expressed on small intestinal CD8+ intraepithelial lymphocytes (IEL), naïve murine CD8+ T cells and by a small population of effector/memory CD8+ T cells, indicating a potential role for CCR9 in regulating CD103 expression and function. Here, we demonstrate that CD103, in contrast to CCR9, is down-regulated on CD8+ T cells following their activation in mesenteric lymph nodes and that effector CD8+ T cells upon initial entry into the small intestinal epithelium are CCR9+CD103-. CD103 was rapidly induced on wild-type CD8+ T cells subsequent to their entry into the small intestinal epithelium, however, CCR9-/- CD8+ T cells exhibited a significant delay in CD103 induction at this site. In addition, the CCR9 ligand, CCL25, that is constitutively expressed in the small intestinal epithelium, induced transient, dose-dependent and pertussis toxin-sensitive CD103-mediated adhesion of CD8+ small intestinal IEL to a murine E-cadherin human Fc (mEFc) fusion protein. Together, these results demonstrate a role for CCR9/CCL25 in promoting the induction and function of CD103 on CD8+ IEL and suggest that this chemokine receptor/chemokine pair may function to regulate lymphocyte-epithelial interactions in the small intestinal mucosa. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
T lymphocyte, Chemokine, Integrin, Adhesion, Epithelium
in
European Journal of Immunology
volume
34
issue
10
pages
2720 - 2729
publisher
John Wiley & Sons
external identifiers
  • wos:000224517800011
  • pmid:15368288
  • scopus:7244248660
ISSN
1521-4141
DOI
10.1002/eji.200425125
language
English
LU publication?
yes
id
f78779a7-4e6a-467a-8c42-e052e20aa940 (old id 127383)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15368288&dopt=Abstract
date added to LUP
2007-07-12 08:28:42
date last changed
2017-08-06 03:31:06
@article{f78779a7-4e6a-467a-8c42-e052e20aa940,
  abstract     = {The integrin CD103 and the chemokine receptor CCR9 are co-expressed on small intestinal CD8+ intraepithelial lymphocytes (IEL), naïve murine CD8+ T cells and by a small population of effector/memory CD8+ T cells, indicating a potential role for CCR9 in regulating CD103 expression and function. Here, we demonstrate that CD103, in contrast to CCR9, is down-regulated on CD8+ T cells following their activation in mesenteric lymph nodes and that effector CD8+ T cells upon initial entry into the small intestinal epithelium are CCR9+CD103-. CD103 was rapidly induced on wild-type CD8+ T cells subsequent to their entry into the small intestinal epithelium, however, CCR9-/- CD8+ T cells exhibited a significant delay in CD103 induction at this site. In addition, the CCR9 ligand, CCL25, that is constitutively expressed in the small intestinal epithelium, induced transient, dose-dependent and pertussis toxin-sensitive CD103-mediated adhesion of CD8+ small intestinal IEL to a murine E-cadherin human Fc (mEFc) fusion protein. Together, these results demonstrate a role for CCR9/CCL25 in promoting the induction and function of CD103 on CD8+ IEL and suggest that this chemokine receptor/chemokine pair may function to regulate lymphocyte-epithelial interactions in the small intestinal mucosa.},
  author       = {Ericsson, Anna and Svensson Frej, Marcus and Arya, Anu and Agace, William},
  issn         = {1521-4141},
  keyword      = {T lymphocyte,Chemokine,Integrin,Adhesion,Epithelium},
  language     = {eng},
  number       = {10},
  pages        = {2720--2729},
  publisher    = {John Wiley & Sons},
  series       = {European Journal of Immunology},
  title        = {CCL25/CCR9 promotes the induction and function of CD103 on intestinal intraepithelial lymphocytes.},
  url          = {http://dx.doi.org/10.1002/eji.200425125},
  volume       = {34},
  year         = {2004},
}