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Complementary therapy in asthma: inhaled corticosteroids and what?

Bjermer, Leif LU and Diamant, Zuzana (2009) In Current Opinion in Pulmonary Medicine 15(1). p.46-51
Abstract
PURPOSE OF REVIEW: For optimal asthma control, complementary strategies are advocated to cover several aspects of the disease. This mini-review highlights different complementary strategies with special focus on the combined use of inhaled corticosteroids (ICSs) and long-acting beta2 agonists and as an alternative, the combination of ICSs and antileukotrienes. RECENT FINDINGS: New data show that combinations of ICSs/long-acting beta2 agonists or ICSs with antileukotrienes improve disease stability with concomitant control of the underlying airway inflammation. Moreover, there is some evidence that combination therapy may prevent some aspects of airway remodelling. The use of a fixed combination of both a reliever and a controller... (More)
PURPOSE OF REVIEW: For optimal asthma control, complementary strategies are advocated to cover several aspects of the disease. This mini-review highlights different complementary strategies with special focus on the combined use of inhaled corticosteroids (ICSs) and long-acting beta2 agonists and as an alternative, the combination of ICSs and antileukotrienes. RECENT FINDINGS: New data show that combinations of ICSs/long-acting beta2 agonists or ICSs with antileukotrienes improve disease stability with concomitant control of the underlying airway inflammation. Moreover, there is some evidence that combination therapy may prevent some aspects of airway remodelling. The use of a fixed combination of both a reliever and a controller medication may have certain advantages compared with a fixed dose regime with as-needed separate reliever therapy. Alternatively, in some asthma phenotypes, such as combined allergic rhinitis and asthma syndrome, the combination of ICSs with antileukotrienes offers a complementary anti-inflammatory treatment in combination with controller effects on both airway compartments. SUMMARY: This review compares different strategies of complementary therapy in asthma with special focus on how to achieve the best clinical control also aimed at controlling the underlying airway inflammation. We have chosen to focus on two major topics: the use of ICSs and long-acting beta2 agonists in two different strategies, that is, a symptom-driven versus a fixed symptom-preventive approach; and the use of ICSs with a long-acting beta2 agonist versus ICSs and a leukotriene receptor antagonist. What regime should be chosen is highly dependent on the individual phenotype and defined treatment goal. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Pulmonary Medicine
volume
15
issue
1
pages
46 - 51
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000262330600009
  • pmid:19077705
  • scopus:58149290053
ISSN
1531-6971
DOI
10.1097/MCP.0b013e32831da926
language
English
LU publication?
yes
id
ec973df8-1121-47fc-a8cd-6dd842b69b1c (old id 1276217)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19077705?dopt=Abstract
date added to LUP
2009-01-09 12:22:11
date last changed
2017-12-10 04:44:24
@article{ec973df8-1121-47fc-a8cd-6dd842b69b1c,
  abstract     = {PURPOSE OF REVIEW: For optimal asthma control, complementary strategies are advocated to cover several aspects of the disease. This mini-review highlights different complementary strategies with special focus on the combined use of inhaled corticosteroids (ICSs) and long-acting beta2 agonists and as an alternative, the combination of ICSs and antileukotrienes. RECENT FINDINGS: New data show that combinations of ICSs/long-acting beta2 agonists or ICSs with antileukotrienes improve disease stability with concomitant control of the underlying airway inflammation. Moreover, there is some evidence that combination therapy may prevent some aspects of airway remodelling. The use of a fixed combination of both a reliever and a controller medication may have certain advantages compared with a fixed dose regime with as-needed separate reliever therapy. Alternatively, in some asthma phenotypes, such as combined allergic rhinitis and asthma syndrome, the combination of ICSs with antileukotrienes offers a complementary anti-inflammatory treatment in combination with controller effects on both airway compartments. SUMMARY: This review compares different strategies of complementary therapy in asthma with special focus on how to achieve the best clinical control also aimed at controlling the underlying airway inflammation. We have chosen to focus on two major topics: the use of ICSs and long-acting beta2 agonists in two different strategies, that is, a symptom-driven versus a fixed symptom-preventive approach; and the use of ICSs with a long-acting beta2 agonist versus ICSs and a leukotriene receptor antagonist. What regime should be chosen is highly dependent on the individual phenotype and defined treatment goal.},
  author       = {Bjermer, Leif and Diamant, Zuzana},
  issn         = {1531-6971},
  language     = {eng},
  number       = {1},
  pages        = {46--51},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Current Opinion in Pulmonary Medicine},
  title        = {Complementary therapy in asthma: inhaled corticosteroids and what?},
  url          = {http://dx.doi.org/10.1097/MCP.0b013e32831da926},
  volume       = {15},
  year         = {2009},
}