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Determinants of increasing pulse pressure during 23 years' follow-up as a marker of arterial stiffness and vascular ageing.

Mokhtari, Arash X LU ; Bellinetto-Ford, Lisa LU ; Melander, Olle LU and Nilsson, Peter LU (2008) In Blood Pressure 17(5-6). p.291-297
Abstract
The aim was to investigate clinical characteristics of increased brachial pulse pressure (PP) during long-term follow-up (23 years) as a marker of arterial stiffness in 9704 healthy subjects. The association of baseline variables with an increasing PP burden during the study period was analysed by univariate analysis. In addition, the association between different biological variables at baseline and increasing PP at follow-up, as well as the cross-sectional association with PP at follow-up, were examined by multiple regression analysis. The prospective analysis showed in men that the following baseline variables predicted (p<0.05) increased PP at follow-up: age, fasting glucose, triglycerides, heart rate, smoking, family history of... (More)
The aim was to investigate clinical characteristics of increased brachial pulse pressure (PP) during long-term follow-up (23 years) as a marker of arterial stiffness in 9704 healthy subjects. The association of baseline variables with an increasing PP burden during the study period was analysed by univariate analysis. In addition, the association between different biological variables at baseline and increasing PP at follow-up, as well as the cross-sectional association with PP at follow-up, were examined by multiple regression analysis. The prospective analysis showed in men that the following baseline variables predicted (p<0.05) increased PP at follow-up: age, fasting glucose, triglycerides, heart rate, smoking, family history of hypertension and cholesterol. Among women, the same predictors were established (p<0.05), except for smoking and triglycerides, but in addition body mass index (BMI). The cross-sectional analysis obtained at the last survey, showed that the following variables (p<0.05) were associated with increased PP in men: fasting glucose, age, BMI, cholesterol and family history of hypertension. In females, similar findings were noted (p<0.05), but in addition there was a negative correlation with smoking. In conclusion, several well-known cardiovascular risk factors, such as glucose, BMI, heart rate, family history of hypertension and cholesterol in particular, are long-term predictors of increased PP in both genders. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood Pressure
volume
17
issue
5-6
pages
291 - 297
publisher
Taylor & Francis
external identifiers
  • wos:000261736200008
  • pmid:19048424
  • scopus:58049118082
ISSN
0803-7051
DOI
10.1080/08037050802584313
language
English
LU publication?
yes
id
b7894a78-d486-4b98-ac15-07b6a3b72660 (old id 1276595)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19048424?dopt=Abstract
date added to LUP
2009-01-09 08:26:50
date last changed
2017-01-01 07:29:29
@article{b7894a78-d486-4b98-ac15-07b6a3b72660,
  abstract     = {The aim was to investigate clinical characteristics of increased brachial pulse pressure (PP) during long-term follow-up (23 years) as a marker of arterial stiffness in 9704 healthy subjects. The association of baseline variables with an increasing PP burden during the study period was analysed by univariate analysis. In addition, the association between different biological variables at baseline and increasing PP at follow-up, as well as the cross-sectional association with PP at follow-up, were examined by multiple regression analysis. The prospective analysis showed in men that the following baseline variables predicted (p&lt;0.05) increased PP at follow-up: age, fasting glucose, triglycerides, heart rate, smoking, family history of hypertension and cholesterol. Among women, the same predictors were established (p&lt;0.05), except for smoking and triglycerides, but in addition body mass index (BMI). The cross-sectional analysis obtained at the last survey, showed that the following variables (p&lt;0.05) were associated with increased PP in men: fasting glucose, age, BMI, cholesterol and family history of hypertension. In females, similar findings were noted (p&lt;0.05), but in addition there was a negative correlation with smoking. In conclusion, several well-known cardiovascular risk factors, such as glucose, BMI, heart rate, family history of hypertension and cholesterol in particular, are long-term predictors of increased PP in both genders.},
  author       = {Mokhtari, Arash X and Bellinetto-Ford, Lisa and Melander, Olle and Nilsson, Peter},
  issn         = {0803-7051},
  language     = {eng},
  number       = {5-6},
  pages        = {291--297},
  publisher    = {Taylor & Francis},
  series       = {Blood Pressure},
  title        = {Determinants of increasing pulse pressure during 23 years' follow-up as a marker of arterial stiffness and vascular ageing.},
  url          = {http://dx.doi.org/10.1080/08037050802584313},
  volume       = {17},
  year         = {2008},
}