Ion specific protein assembly and hydrophobic surface forces
(2008) In Physical Review Letters 100(25).- Abstract
- Large anions are attracted to hydrophobic surfaces while smaller, well solvated ions are repelled. Using a combination of explicit solvent and continuum model simulations we show that this leads to significant ion-specific protein-protein interactions due to hydrophobic patches on the protein surfaces. In solutions of NaI and NaCl we calculate the potentials of mean force and find that the resulting second virial coefficients for lysozyme correspond well with experiment. We argue that ionic interactions with nonpolar surface groups may play an important role for biomolecular assembly and Hofmeister-type effects.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1278266
- author
- Lund, Mikael LU ; Jungwirth, Pavel and Clifford, Woodward
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physical Review Letters
- volume
- 100
- issue
- 25
- article number
- 258105
- publisher
- American Physical Society
- external identifiers
-
- scopus:46349089977
- pmid:18643709
- ISSN
- 1079-7114
- DOI
- 10.1103/PhysRevLett.100.258105
- language
- English
- LU publication?
- no
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Theoretical Chemistry (S) (011001039)
- id
- 761ef0d3-6710-4472-aa08-79e9463e6e07 (old id 1278266)
- date added to LUP
- 2016-04-04 11:34:43
- date last changed
- 2022-01-29 22:04:08
@article{761ef0d3-6710-4472-aa08-79e9463e6e07, abstract = {{Large anions are attracted to hydrophobic surfaces while smaller, well solvated ions are repelled. Using a combination of explicit solvent and continuum model simulations we show that this leads to significant ion-specific protein-protein interactions due to hydrophobic patches on the protein surfaces. In solutions of NaI and NaCl we calculate the potentials of mean force and find that the resulting second virial coefficients for lysozyme correspond well with experiment. We argue that ionic interactions with nonpolar surface groups may play an important role for biomolecular assembly and Hofmeister-type effects.}}, author = {{Lund, Mikael and Jungwirth, Pavel and Clifford, Woodward}}, issn = {{1079-7114}}, language = {{eng}}, number = {{25}}, publisher = {{American Physical Society}}, series = {{Physical Review Letters}}, title = {{Ion specific protein assembly and hydrophobic surface forces}}, url = {{http://dx.doi.org/10.1103/PhysRevLett.100.258105}}, doi = {{10.1103/PhysRevLett.100.258105}}, volume = {{100}}, year = {{2008}}, }