A galabiose-based two-dimensional scaffold for the synthesis of inhibitors targeting Pk- and P-antigen binding proteins.
(2003) In Tetrahedron Letters 44(14). p.2785-2787- Abstract
- A disaccharide scaffold based on galabiose (Gal1–4Gal) was synthesized. Four different acceptors were evaluated in the -galactosylation and a relationship between the nucleophilicity, yield, and /-selectivity was found. The scaffold contains two orthogonal derivatisation sites, i.e. at O-2′ and the anomeric position, and as proof of concept, one derivatised galabioside was synthesized. Compounds based on this galabiose-scaffold are potential inhibitors of P- and Pk-antigen binding proteins.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/127972
- author
- Ohlsson, Jörgen LU and Nilsson, Ulf LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Tetrahedron Letters
- volume
- 44
- issue
- 14
- pages
- 2785 - 2787
- publisher
- Elsevier
- external identifiers
-
- wos:000181893800004
- scopus:0037474663
- ISSN
- 0040-4039
- DOI
- 10.1016/S0040-4039(03)00475-1
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- ab5f9e01-390c-439c-a7de-f0f3d616cbdf (old id 127972)
- date added to LUP
- 2016-04-01 16:59:48
- date last changed
- 2022-01-28 23:39:16
@article{ab5f9e01-390c-439c-a7de-f0f3d616cbdf, abstract = {{A disaccharide scaffold based on galabiose (Gal1–4Gal) was synthesized. Four different acceptors were evaluated in the -galactosylation and a relationship between the nucleophilicity, yield, and /-selectivity was found. The scaffold contains two orthogonal derivatisation sites, i.e. at O-2′ and the anomeric position, and as proof of concept, one derivatised galabioside was synthesized. Compounds based on this galabiose-scaffold are potential inhibitors of P- and Pk-antigen binding proteins.}}, author = {{Ohlsson, Jörgen and Nilsson, Ulf}}, issn = {{0040-4039}}, language = {{eng}}, number = {{14}}, pages = {{2785--2787}}, publisher = {{Elsevier}}, series = {{Tetrahedron Letters}}, title = {{A galabiose-based two-dimensional scaffold for the synthesis of inhibitors targeting Pk- and P-antigen binding proteins.}}, url = {{http://dx.doi.org/10.1016/S0040-4039(03)00475-1}}, doi = {{10.1016/S0040-4039(03)00475-1}}, volume = {{44}}, year = {{2003}}, }