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A galabiose-based two-dimensional scaffold for the synthesis of inhibitors targeting Pk- and P-antigen binding proteins.

Ohlsson, Jörgen LU and Nilsson, Ulf LU (2003) In Tetrahedron Letters 44(14). p.2785-2787
Abstract
A disaccharide scaffold based on galabiose (Gal1–4Gal) was synthesized. Four different acceptors were evaluated in the -galactosylation and a relationship between the nucleophilicity, yield, and /-selectivity was found. The scaffold contains two orthogonal derivatisation sites, i.e. at O-2′ and the anomeric position, and as proof of concept, one derivatised galabioside was synthesized. Compounds based on this galabiose-scaffold are potential inhibitors of P- and Pk-antigen binding proteins.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Tetrahedron Letters
volume
44
issue
14
pages
2785 - 2787
publisher
Elsevier
external identifiers
  • wos:000181893800004
  • scopus:0037474663
ISSN
0040-4039
DOI
10.1016/S0040-4039(03)00475-1
language
English
LU publication?
yes
id
ab5f9e01-390c-439c-a7de-f0f3d616cbdf (old id 127972)
date added to LUP
2007-07-10 13:25:08
date last changed
2018-05-29 10:29:21
@article{ab5f9e01-390c-439c-a7de-f0f3d616cbdf,
  abstract     = {A disaccharide scaffold based on galabiose (Gal1–4Gal) was synthesized. Four different acceptors were evaluated in the -galactosylation and a relationship between the nucleophilicity, yield, and /-selectivity was found. The scaffold contains two orthogonal derivatisation sites, i.e. at O-2′ and the anomeric position, and as proof of concept, one derivatised galabioside was synthesized. Compounds based on this galabiose-scaffold are potential inhibitors of P- and Pk-antigen binding proteins.},
  author       = {Ohlsson, Jörgen and Nilsson, Ulf},
  issn         = {0040-4039},
  language     = {eng},
  number       = {14},
  pages        = {2785--2787},
  publisher    = {Elsevier},
  series       = {Tetrahedron Letters},
  title        = {A galabiose-based two-dimensional scaffold for the synthesis of inhibitors targeting Pk- and P-antigen binding proteins.},
  url          = {http://dx.doi.org/10.1016/S0040-4039(03)00475-1},
  volume       = {44},
  year         = {2003},
}